1974
DOI: 10.1021/jm00251a007
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.beta.-Adrenoceptor studies. 1. In vitro .beta.-adrenergic blocking, antiarrhythmic, and local anesthetic activities of a new series of aromatic bis(2-hydroxy-3-isopropylaminopropyl) ethers

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Cited by 28 publications
(13 citation statements)
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“…Materials-The following radiolabeled and nonradiolabeled drugs were used: l,"H!chlorprornazine [New England Nuclear (NEN), 17 were presaturated with each other. Mixing with drug was achieved by manually inverting the solution 100 times and separating each phase by centrifugation at 2000 x g for 15 min at 37 "C. Each phase was sampled and counted in scintillant fluid [toluene:triton-x (2: 1) and 0.441 PPO].…”
Section: Methodsmentioning
confidence: 99%
“…Materials-The following radiolabeled and nonradiolabeled drugs were used: l,"H!chlorprornazine [New England Nuclear (NEN), 17 were presaturated with each other. Mixing with drug was achieved by manually inverting the solution 100 times and separating each phase by centrifugation at 2000 x g for 15 min at 37 "C. Each phase was sampled and counted in scintillant fluid [toluene:triton-x (2: 1) and 0.441 PPO].…”
Section: Methodsmentioning
confidence: 99%
“…The reaction of 4-hydroxybenzaldehyde with 2-chloroethanol and epichlorohydrin, respectively, in 1,4-dioxane and water gave the expected derivatives 3a and 2e in good yield [14,15]. The intermediate 2-butoxyethyl-4-methylbenzene sulfonate was prepared from the commercially available 2-butoxyethanol and TsCl according to already published methods [16].…”
Section: Chemistrymentioning
confidence: 99%
“…Compounds 1 and 2 were prepared according to the literature , and their chemical structures were determined by 1 H NMR spectroscopy.…”
Section: Methodsmentioning
confidence: 99%
“…However, in the recent two years, increasing number of papers has been published on preparative enantioseparation by countercurrent chromatography [24][25][26][27][28][29][30][31][32][33]. Unfortunately, only five papers reporting successful chiral separations could be found in the literature when it comes to pH-zone-refining countercurrent chromatography since 1990s [34][35][36][37][38]. This fact is mainly caused by the difficulty of finding suitable enantioseparation conditions for pH-zone-refining elution mode, and not all the racemic analytes are ionic components.…”
Section: Introductionmentioning
confidence: 99%