Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates

Nijssen, S.; Florijn, Alice; Bonten, Marc J. M.; Schmitz, Franz‐Josef; Verhoef, J.; Fluit, Ad C.

doi:10.1016/j.ijantimicag.2004.08.008

Cited by 100 publications

(77 citation statements)

References 19 publications

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“…In vitro activities of antimicrobial agents showed that the resistance rate of Enterobacteriaceae to ticarcillin (91.2%) This result is disagrees with the result obtained by Nijssen et al, [10].…”

Section: Discussioncontrasting

confidence: 79%

Determination of Antimicrobial Resistance of <i>Enterobacteriaceae</i> in Patients with Community Acquired Urinary Tract Infections

Osman¹

2017

AJLM

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Abstract:This study was conducted in Port Sudan city, Red Sea state during the period from January to June 2017 to investigate antimicrobial resistance of Enterobacteriaceae isolated from patients suffering from community acquired urinary tract infections. One hundred and fifty urine specimens were collected from patients attended Port Sudan Teaching Hospital. The specimens were cultured on blood agar and Mac Conkey's agar and Cystine Lysine Electrolyte deficient (CLED) agar for primary isolation of pathogens. Identification of the isolates was done by colonial morphology, Gram stain and Routine biochemical tests. Modified Kirby-Bauer disc diffusion method was adopted to determine the resistance rate of Enterobacteriaceae to Imipenem, Ciprofloxacin, Chloramphenicol, Amikacin, Piperacillin, Tetracycline, Ceftazidime and Ticarcillin. Out one hundred and fifty urine specimens examined Enterobacteriaceae was detected in only 49(32.6%) specimens. The results revealed that the antimicrobial resistance of Enterobacteriaceae was as follows: Imipenem (6.1%), Ciprofloxacin (32.6%), Chloramphenicol (48.9%), Amikacin (61.2%), Piperacillin (79.5%), Tetracycline (83.6%), Ceftazidime (89.7%) and Ticarcillin (91.8%). Females were more affected than males (60%) and young adults were more affected than other age groups. Imipenem represented the least sensitive antimicrobial agent (6.1%), while Ticarcillin showed the highest resistance rate.

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Section: Discussioncontrasting

confidence: 79%

Determination of Antimicrobial Resistance of <i>Enterobacteriaceae</i> in Patients with Community Acquired Urinary Tract Infections

Osman¹

2017

AJLM

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“…In our study, the frequency of ceftriaxone resistance was 31%, which is higher than the rates reported in studies in the Netherlands (18.7%) and in the USA (10%) (27,28). The inconsistency in the antibiotic resistance rates might be due to differences in geographical area, type of antibiotics used, type of samples and indiscriminate use of antibiotics (29,30).…”

Section: Discussioncontrasting

confidence: 76%

Evaluation of Antibiotic Resistance Patterns of Clinical Klebsiella pneumoniae Isolates from Educational Hospitals in Zahedan, Iran

et al. 2018

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Background and Objectives: The resistance of gram-negative bacteria to antibiotics has become a serious problem, which imposes a significant increase in treatment costs. Klebsiella pneumoniae is an important nosocomial pathogen from the Enterobacteriaceae family. The aim of this study was to investigate the frequency and pattern of antibiotic resistance in K. pneumoniae strains isolated from clinical samples.Methods: This descriptive, cross-sectional study was performed on 150 K. pneumonia strains isolated from different clinical samples such as urine, sputum, blood, ulcers, lung secretions and abdominal abscess. Antibiogram test was performed using the disk diffusion method (Kirby-Bauer). Minimum inhibitory concentration of amikacin, tobramycin and gentamicin was determined via the E-test for 50 strains with high resistance rates.Results: In this study, the highest rate of resistance was observed against carbenicilin, ceftriaxone, cefepime and streptomycin. K. pneumonia isolates were most frequent in urine and sputum samples. In the E-test, the highest rate of resistance was observed against gentamicin, tobramycin (16µg/ml) and amikacin (64µg/ml).Conclusion: Based on our results, tigecycline, netilmicin, kanamycin and amikacin are the most effective antibiotics for the treatment of K. pneumoniae infections.

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“…ESBLs are emerging both in the community and in hospitals and have increasingly been described worldwide since their introduction (Bonnet, 2004;Cantó n et al, 2008;Nijssen et al, 2004). The most frequently detected and clinically important ESBLs belong to the TEM, SHV and CTX-M families (Endimiani et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Rapid molecular detection of extended-spectrum β-lactamase gene variants with a novel ligation-mediated real-time PCR

Nijhuis

Zwet

Stuart

et al. 2012

Journal of Medical Microbiology

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Extended-spectrum b-lactamases (ESBLs) are emerging worldwide, making rapid and adequate ESBL detection crucial for infection control measures as well as for the choice of correct antimicrobial therapy. The aim of this study was to compare the performance of a novel rapid ligation-mediated real-time PCR (LM-PCR) with a combination disc test (CDT). In total, 172 prospective putative ESBL-positive Enterobacteriaceae isolates from clinical specimens based on VITEK2 results were included in this study and tested with the phenotypic CDT and the LM-PCR. Positive ESBL results were obtained in 100 and 95 isolates using CDT and LM-PCR, respectively. The sensitivity, specificity, negative predictive value and positive predictive value of the LM-PCR were 99.0, 92.2, 98.6 and 94.0 %, respectively, compared with the CDT. The LM-PCR technique provides an important reduction in turnaround time (~4.5 h versus overnight incubation using CDT) for ESBL confirmation. As a consequence, all ESBL results are available within the same day, making this assay an important tool for rapid and accurate ESBL detection.

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Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates

Cited by 100 publications

References 19 publications

Determination of Antimicrobial Resistance of <i>Enterobacteriaceae</i> in Patients with Community Acquired Urinary Tract Infections

Determination of Antimicrobial Resistance of <i>Enterobacteriaceae</i> in Patients with Community Acquired Urinary Tract Infections

Evaluation of Antibiotic Resistance Patterns of Clinical Klebsiella pneumoniae Isolates from Educational Hospitals in Zahedan, Iran

Rapid molecular detection of extended-spectrum β-lactamase gene variants with a novel ligation-mediated real-time PCR

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Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates

Cited by 100 publications

References 19 publications

Determination of Antimicrobial Resistance of &lt;i&gt;Enterobacteriaceae&lt;/i&gt; in Patients with Community Acquired Urinary Tract Infections

Determination of Antimicrobial Resistance of &lt;i&gt;Enterobacteriaceae&lt;/i&gt; in Patients with Community Acquired Urinary Tract Infections

Evaluation of Antibiotic Resistance Patterns of Clinical Klebsiella pneumoniae Isolates from Educational Hospitals in Zahedan, Iran

Rapid molecular detection of extended-spectrum β-lactamase gene variants with a novel ligation-mediated real-time PCR

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Determination of Antimicrobial Resistance of <i>Enterobacteriaceae</i> in Patients with Community Acquired Urinary Tract Infections

Determination of Antimicrobial Resistance of <i>Enterobacteriaceae</i> in Patients with Community Acquired Urinary Tract Infections