Beta-thromboglobulin is elevated in renal failure without thrombosis

Deppermann, D.; Andrássy, K.; Seelig, H. P.; Ritz, Eberhard; Post, David

doi:10.1016/0049-3848(80)90294-7

Cited by 61 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data were evaluated by means of the Kruskal-Wallis one-way analysis of variance (9, lo), and by the tion during pre-eclampsia was documented by increased plasma level o f 5-hydroxytryptamine (20), and BTG as well (15). The plasma 0-thromboglobulin level was elevated in patients with renal failure in the absence of thrombosis as reported by Depperman et al (6). They showed that P-thromboglobulin resembles & microglobulin in renal failure and suggested that both proteins are taken u p and partly catabolized by the proximal tubular cells.…”

supporting

confidence: 68%

See 1 more Smart Citation

Beta‐thromboglobulin in Pre‐eclampsia

Leiberman

Aharon

Schuster

et al. 1985

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Beta-thromboglobulin was tested in blood and urine in a study group of pre-eclamptic patients. The control group comprised a subgroup of normal non-pregnant women and a second subgroup of normal pregnant women. The results of the plasma beta-thromboglobulin blood test revealed no significant difference between the groups, whereas the urine of the pre-eclamptic group showed a significantly increased concentration of beta-thromboglobulin. This difference may reflect renal involvement in the pre-eclamptic patients; the turnover of platelets may be increased but the plasma level of beta-thromboglobulin is apparently maintained by the increased renal clearance.

show abstract

supporting

confidence: 68%

“…(1 5) measured plasma BTG and found significantly higher values in 10 patients with established pre-eclampsia. Depperman et al (6) found an average value in plasma of 33.9 ng/ml BTG in 20 healthy volunteers, although only 5 females were included in his group. Our mean normal BTG value was 46.87 ng/ml in plasma.…”

Section: Resultsmentioning

confidence: 96%

Beta‐thromboglobulin in Pre‐eclampsia

Leiberman

Aharon

Schuster

et al. 1985

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…We have found that the therapeutical effect significantly parallels a reduction in plasma [ITG levels. It has also been suggested that plasma PTG levels are increased in renal insufficiency due to decreased clear ance of PTG by the kidney [12]. Therefore, its plasma levels should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dipyridamole Treatment on Proteinuria in Pediatric Renal Disease

Ueda¹,

Kawaguchi²,

Niinomi³

et al. 1986

Nephron

View full text Add to dashboard Cite

The effect of dipyridamole on proteinuria was studied in 60 children with various renal diseases. A significant decrease in 24-hour urine protein excretion was observed within a few months after treatment in 32 (53%) of the patients with minimal or moderate mesangial proliferation. The effect was reproducible and parallelled by a reduction in plasma levels of β-thromboglobulin. Renal function in patients significantly improved with the therapeutical effect. The appropriate dosage was 4–10 mg/kg daily and no serious toxicity was seen despite large dosage and even in long-term application. The data suggest that dipyridamole treatment appears safe and has a beneficial effect on proteinuria dependent on its effect on platelets in renal disease.

show abstract

“…It may be difficult to interpret an elevated 8-TG in the presence of renal failure since excretion of 6-TG is impaired in this condition [4]. Only Case 8 in this series had serum creatinine greater than 1.5 mg% at the time of sampling.…”

Section: Discussionmentioning

confidence: 90%

Clinical use of β‐thromboglobulin levels in diagnosing and treating consumptive and immune thrombocytopenia

Rubenstein

Wall

1981

American J Hematol

View full text Add to dashboard Cite

Plasma beta-thromboglobulin (beta-TG), a platelet-specific protein, is a marker of intravascular platelet degranulation. We measured plasma beta-thromboglobulin by radioimmunoassay in 13 patients with thrombocytopenia of various etiologies to determine whether or not the test is clinically useful in the differential diagnosis of thrombocytopenia. Four patients with intravascular platelet consumption (three with thrombotic thrombocytopenic purpura and one with vasculitis) had significantly higher plasma beta-thromboglobulin levels than four patients with extravascular platelet destruction due to idiopathic thrombocytopenic purpura. Five patients with thrombocytopenia and decreased numbers of megakaryocytes in the bone marrow also had beta-thromboglobulin levels that were not elevated. Two patients with thrombotic thrombocytopenic purpura achieved clinical remission associated with a decrease in beta-TG level to the normal range. Plasma beta-thromboglobulin determination can be useful in determining the mechanism of thrombocytopenia when bone marrow examination demonstrates adequate megakaryocyte numbers.

show abstract

Beta-thromboglobulin is elevated in renal failure without thrombosis

Cited by 61 publications

References 9 publications

Beta‐thromboglobulin in Pre‐eclampsia

Beta‐thromboglobulin in Pre‐eclampsia

Effect of Dipyridamole Treatment on Proteinuria in Pediatric Renal Disease

Clinical use of β‐thromboglobulin levels in diagnosing and treating consumptive and immune thrombocytopenia

Contact Info

Product

Resources

About