Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication

Erman, Fazilet; Balkan, Jale; Çevikbaş, Uğur; Koçak‐Toker, Necla; Uysal, Müjdat

doi:10.1007/s00726-004-0105-5

Cited by 75 publications

(48 citation statements)

References 35 publications

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“…Protective effects of these agents are attributed to their alleviating effects on synthesis of free oxygen, nitrites and nitrate radicals. [20,24,34,35,55,56] In our study, IAP increase was found to increase the inflammatory response and reperfusion-related oxidative damage. Oxidative damage was established with an increase in MDA levels and decrease in GSH levels in the lung, liver and small intestine tissues; inflammatory response was established with an increase in MPO activity in the liver and small intestine tissues.…”

Section: Discussionsupporting

confidence: 60%

The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats

Tıhan

Erbil²,

Seven³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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AMAÇBu çalışmada, antioksidan özelliği bilinen glutaminin kullanımının iskemi-reperfüzyon sonrası oluşabilecek oksidasyon hasarı üzerindeki etkilerini araştırmayı amaçladık. GEREÇ VE YÖNTEMÇalışma grubu Wistar Albino sıçanlarla oluşturuldu. Grup 1, abdominal kompartman grubuydu. Anestezi altındaki sı-çanların karnına basınç uygulandı. Gaz boşaltıldıktan 3 gün sonra sıçanlar sakrifiye edildi, karaciğer, bağırsak ve akciğer doku parçalarında oksidatif hasar parametresi olarak malonildialdehit (MDA) ve glutatyon (GSH) seviyeleri ile enflamatuvar parametre olarak miyeloperoksidaz (MPO) aktivitesi ölçüldü. Alınan kan örneklerinde serum alaninaminoasit transferaz (ALT) ve aspartat-aminoasit transferaz (AST) seviyeleri ölçüldü. Grup 2, abdominal kompartman ve glutamin uygulanan gruptu. Sıçanlara 1 hafta boyunca yüksek doz glutamin mide gavajı yolu ile verildi. Gavaj işlemi sonrası ilk gruptaki batın içi basınç uygulaması yapıldı, 3 gün daha glutamin verilen sıçanlar sakrifiye edildi, Grup 1'deki işlemlerin aynısı yapıldı. Grup 3 glutamin grubuydu. Grup 4 sham kontrol grubuydu. BULGULARAbdominal kompartman yaratılan sıçanlarda MDA düzeyi ve MPO aktivitesi kontrol grubuna göre anlamlı oranda artmıştı. Glutamin ile MDA düzeyi ve MPO aktivitesi azaldı, GSH seviyesi arttı. SONUÇOksidatif hasar parametrelerine bakıldığında, glutaminin, reperfüzyon hasarını azaltıcı etkisinin antienflamatuvar ve antioksidan etkilerine bağlı olduğu düşünülmüştür.

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Section: Discussionsupporting

confidence: 60%

The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats

Tıhan

Erbil²,

Seven³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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“…It probably did so by its antioxidant action (Go et al 2007) against restraint stress-induced lipid peroxidation. Previous studies by Erman et al (2004) indicated that lipotropes inhibit lipid peroxidation in cellular membranes as a result of distinct biophysical interactions with membrane lipid bilayer. Administration of betaine has already been reported to exert antioxidant action through forcing structural interactions with membrane lipids .…”

Section: Resultsmentioning

confidence: 99%

“…Subacute and subchronic rat studies determined that betaine is nontoxic at all doses studied (0-5% of the diet) (Hayes et al 2003). Studies by Erman et al (2004) showed that betaine exerted cellular and subcellular membrane stabilization in the liver by restoring both non-enzymic and enzymic antioxidants. It has been shown that betaine is involved in the synthesis of methionine, which serves as a major supplier of cellular cysteine via trans-sulfuration pathway for the synthesis of reduced glutathione that protects the cell from reactive metabolites and reactive oxygen species (Craig 2004).…”

Section: Introductionmentioning

confidence: 98%

Studies on the protective effects of betaine against oxidative damage during experimentally induced restraint stress in Wistar albino rats

Ganesan

Anandan

Lakshmanan

2011

Cell Stress and Chaperones

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Stress can be defined as physical and psychological modifications that disrupt the homeostasis and the balance of organisms. Stress is known as one of the most important reasons of several diseases. In the present study, the anti-stress effect of betaine was evaluated with reference to its antioxidant property. Wistar albino rats were divided into four groups such as control, betaine, restraint stress (6 h/day for 30 days), and betaine+restraint stress. The oxidative damage was assessed by measuring the protein and corticosterone in plasma, lipid peroxidation, nonenzymic (reduced glutathione), and enzymic antioxidants (glutathione peroxidase, glutathione-S-transferase, catalase, and superoxide dismutase) in the lymphoid organs of thymus and spleen. Followed by the induction of restraint stress, the non-enzymic and enzymic antioxidants were significantly decreased with concomitant increase observed in the levels of corticosterone and lipid peroxidation. Oral pretreatment with betaine (250 mg/kg body weight daily for a period of 30 days) significantly (P<0.001) prevented the restraint stress-induced alterations in the levels of protein and corticosterone in plasma of experimental groups of rats. It counteracted the restraint stress-induced lipid peroxidation and maintained the antioxidant defense system in the lymphoid tissues at near normal. The findings suggest that betaine possesses significant anti-stress activity, which may be due to its antioxidant property.

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“…Because brain consumes approximately 29% of oxygen received by organism, ethanol-induced ROS production and consecutive oxidative stress play an important role among the mechanisms of ethanol neurotoxicity [4,48,51]. Previous studies showed that betaine exerted cellular and subcellular membrane stabilization in the liver and myocardium cells by restoring both non-enzymatic and enzymatic antioxidants [24,28]. We have already reported the protective effect of betaine on ethanol-induced hyperhomocystei- nemia in our recent studies [1,2].…”

Section: Discussionmentioning

confidence: 99%

Betaine prevents ethanol-induced oxidative stress and reduces total homocysteine in the rat cerebellum

et al. 2011

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Oxidative stress is a hypothesis for the association of reactive oxygen species with cerebrovascular and neurodegenerative diseases. Thus, we examined whether oral betaine can act as a preventive agent in ethanol-induced oxidative stress on the cerebellum of rats. Thirty-two adult male Sprague-Dawley rats were divided into four equal groups (control, ethanol, betaine, and betaine plus ethanol) with different dietary regimens and were followed up for 1 month. Total homocysteine (tHcy) of plasma and cerebellum homogenate was determined by an Axis(®) homocysteine EIA kit, and antioxidant enzyme (glutathione peroxidase (GPx), SOD, and CAT) activities of cerebellum homogenate were measured chemically by a spectrophotometer. Lipid peroxidation of cerebellum was shown by the measurement of thiobarbituric reactive substances (TBARS) via a spectrophotometer. Ethanol-induced hyperhomocysteinemia was manifested by an increase in the concentrations of tHcy in the plasma and cerebellum homogenates of the ethanol group, while ethanol-induced oxidative stress was indicated via an increase in lipid peroxidation marker (TBARS) in cerebellum homogenates of ethanol-treated rats. In contrast, betaine prevented hyperhomocysteinemia and oxidative stress in the betaine plus ethanol group as well as the betaine group. The results of the present investigation indicated that the protective effect of betaine is probably related to its ability to strengthen the cerebellum membrane cells by enhancement of antioxidant enzyme activity principally GPx, while the methyl donor effect of betaine to reduce hyperhomocysteinemia has been explained previously and confirmed in the present study.

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Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication

Cited by 75 publications

References 35 publications

The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats

The effect of glutamine on oxidative damage in an experimental abdominal compartment syndrome model in rats

Studies on the protective effects of betaine against oxidative damage during experimentally induced restraint stress in Wistar albino rats

Betaine prevents ethanol-induced oxidative stress and reduces total homocysteine in the rat cerebellum

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