Betaine supplementation mitigates cisplatin-induced nephrotoxicity by abrogation of oxidative/nitrosative stress and suppression of inflammation and apoptosis in rats

Hagar, Hanan; Medany, Azza El; Salam, Reem; Medany, Gamila El; Nayal, Omina A.

doi:10.1016/j.etp.2014.11.001

Cited by 84 publications

(57 citation statements)

References 64 publications

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“…Interestingly, betaine significantly alleviated the increase of both LPO and SOD. Our study corroborates the recent findings of Hagar et al [46] who showed that betaine mitigated the increase of LPO and total antioxidant status caused by cisplatin-induced nephrotoxicity. Reactive oxygen species are able to actuate redox-sensitive transcription factors, nuclear factor-κB, and activator protein-1, initiating the genes of pro-inflammatory cytokines TNFα, IL-1β, and IL-6 [47].…”

Section: Discussionsupporting

confidence: 83%

“…In the present study, we also found that betaine averted the increase in plasma concentrations of IL-6 and TNFα caused by a 2-week exposure to WPS, suggesting the systemic anti-inflammatory effects of betaine. Recent studies showed that betaine mitigates the increase of TNFα caused by cisplatin-induced nephrotoxicity [46] and recovery from hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats [50].…”

Section: Discussionmentioning

confidence: 99%

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Water-Pipe Smoke Exposure-Induced Circulatory Disturbances in Mice, and the Influence of Betaine Supplementation Thereon

Al-Salam

Beegam

Yuvaraju

et al. 2017

Cell Physiol Biochem

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Background/Aims: It has been shown, both experimentally and clinically, that water-pipe smoke (WPS) exposure adversely affects the cardiovascular system (CVS) through the generation of oxidative stress and inflammation. Betaine, a naturally occurring compound in common foods, has antioxidant and anti-inflammatory actions. However, its potential to mitigate the adverse effect of WPS on the CVS has never been reported before. This is the subject of this study in mice. Methods: Mice were exposed daily for 30 min to either normal air (control), or to WPS for two consecutive weeks. Betaine was administered daily by gavage at a dose of 10 mg/kg, 1h before either air or WPS exposure. Results: Betaine mitigated the in vivo prothrombotic effect of WPS in pial arterioles and venules. Moreover, it reversed the WPSinduced decrease in circulating platelets. Likewise, betaine alleviated platelet aggregation in vitro, and the shortening of activated partial thromboplastin time and prothrombin time induced by WPS. Betaine reduced the increase of plasminogen activator inhibitor-1 and fibrinogen concentrations in plasma induced by WPS. Betaine also diminished the WPSinduced increase of plasma concentrations of interleukin 6 and tumor necrosis factor α, and attenuated the increase of lipid peroxidation and superoxide dismutase. Immunohistochemical analysis of the heart revealed an increase in the expression of inducible nitric oxide synthase and cytochrome C by cardiomyocytes of the WPS-exposed mice. These effects were averted by betaine. Conclusion: Our findings suggest that betaine treatment significantly mitigated WPS-induced hypercoagulability, and inflammation, as well as systemic and cardiac oxidative stress.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Water-Pipe Smoke Exposure-Induced Circulatory Disturbances in Mice, and the Influence of Betaine Supplementation Thereon

Al-Salam

Beegam

Yuvaraju

et al. 2017

Cell Physiol Biochem

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“…It is recognized that oxidative stress acts as an important pathogenic factor in causing cisplatin-induced acute kidney injury (Malik et al, 2015;Hagar et al, 2015). Normally, inside the cell, mitochondria produce ROS such as superoxides, hydroxyl and hydrogen peroxide regularly via electron transport chain but they are also simultaneously scavenged by anti-oxidant enzymessuperoxide dismutase, glutathione-s-transferase, catalase and glutathione peroxidase (Richter et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects

Malik

Bhatia

Suchal

et al. 2015

Experimental and Toxicologic Pathology

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“…In liver cancer, betaine has a protective effect against the deleterious effects of chemotherapy using cisplatin by limiting the decline of antioxidant enzymes (glutathione disulfide reductase, glutathione peroxidase, catalase, and superoxide dismutase), by eliminating the increase in TBARS concentrations and by attenuating the proinflammatory and apoptotic mediators [23]. …”

Section: Introductionmentioning

confidence: 99%

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

Bingula

Dupuis

Pichon

et al. 2016

Journal of Oncology

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We investigated the effects of betaine, C-phycocyanin (C-PC), and their combined use on the growth of A549 lung cancer both in vitro and in vivo. When cells were coincubated with betaine and C-PC, an up to 60% decrease in viability was observed which is significant compared to betaine (50%) or C-PC treatment alone (no decrease). Combined treatment reduced the stimulation of NF-κB expression by TNF-α and increased the amount of the proapoptotic p38 MAPK. Interestingly, combined treatment induced a cell cycle arrest in G2/M phase for ~60% of cells. In vivo studies were performed in pathogen-free male nude rats injected with A549 cells in their right flank. Their daily food was supplemented with either betaine, C-PC, both, or neither. Compared to the control group, tumour weights and volumes were significantly reduced in either betaine- or C-PC-treated groups and no additional decrease was obtained with the combined treatment. This data indicates that C-PC and betaine alone may efficiently inhibit tumour growth in rats. The synergistic activity of betaine and C-PC on A549 cells growth observed in vitro remains to be further confirmed in vivo. The reason behind the nature of their interaction is yet to be sought.

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Betaine supplementation mitigates cisplatin-induced nephrotoxicity by abrogation of oxidative/nitrosative stress and suppression of inflammation and apoptosis in rats

Cited by 84 publications

References 64 publications

Water-Pipe Smoke Exposure-Induced Circulatory Disturbances in Mice, and the Influence of Betaine Supplementation Thereon

Water-Pipe Smoke Exposure-Induced Circulatory Disturbances in Mice, and the Influence of Betaine Supplementation Thereon

Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects

Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 CellsIn VitroandIn Vivo

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