2019
DOI: 10.21873/anticanres.13500
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Bevacizumab Versus Anti-preeclamptic Drugs: Evaluation With Three-dimensionally Co-cultured Human Mini Tumors

Abstract: Background/Aim: Both bevacizumab (BEV) and soluble fms-like tyrosine kinase-1 (sFlt-1) have demonstrated anti-angiogenic effects, thereby causing hypertension and proteinuria. We hypothesized that anti-preeclamptic drugs that combat the action of sFlt-1 may reduce BEV's antitumor efficacy. Materials and Methods: 3D co-cultured human mini-tumors consisting of endothelial cells, fibroblasts, and cancer cells were developed. The influence of anti-preeclamptic drugs and BEV on the invasion of minitumors embedded i… Show more

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Cited by 3 publications
(3 citation statements)
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“…To overcome these weaknesses, other approaches are based on spheroids assembled with both tumor and endothelial cells, subsequently incorporated into hydrogels or biofilms made of Matrigel or human derived ECM components, as collagen, hyaluronic acid or fibrin. These systems allow better replication of the natural tumor tissue organization (Pan et al, 2019). Hydrogels generate a native tumor-like environment, allowing EC sprouting and tumor cell invasion, critical for brain tumor angiogenesis research (Rustad et al, 2012).…”
Section: Spherical Models-"free" or Matrix-supported Spheroidsmentioning
confidence: 99%
“…To overcome these weaknesses, other approaches are based on spheroids assembled with both tumor and endothelial cells, subsequently incorporated into hydrogels or biofilms made of Matrigel or human derived ECM components, as collagen, hyaluronic acid or fibrin. These systems allow better replication of the natural tumor tissue organization (Pan et al, 2019). Hydrogels generate a native tumor-like environment, allowing EC sprouting and tumor cell invasion, critical for brain tumor angiogenesis research (Rustad et al, 2012).…”
Section: Spherical Models-"free" or Matrix-supported Spheroidsmentioning
confidence: 99%
“…Optical methods that preserve the culture’s structural integrity address this limitation ( Li et al, 2016 ; Pan, Onda & Hirano, 2019 ; Christoffersson et al, 2019 ; Alladin et al, 2020 ). ( Fig.…”
Section: Cell Viability and Proliferationmentioning
confidence: 99%
“…In one study, polyacrylamide coatings fabricated with varying stiffness provided evidence that the stiffness of the surface affects the fusion of mononuclear cytotrophoblasts into syncytiotrophoblasts, which is a critical process taking place throughout the pregnancy, where disease-state mimicking stiffness inhibited the fusion [341]. Another application of in vitro preeclampsia models has been evaluating the off-target effects of antipreeclamptic drugs on cancer treatment with bevacizumab [342]. Tissue engineering is an approach that can be used to study tissues in vitro and to replace damaged or lost organs.…”
Section: Hydrogels For the Encapsulation Of Ovarian Folliclesmentioning
confidence: 99%