Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine

Gies, Vincent; Bekaddour, Nassima; Dieudonné, Yannick; Guffroy, Aurélien; Frenger, Quentin; Gros, Frédéric; Rodero, Mathieu P; Herbeuval, Jean-Philippe; Korganow, Anne‐Sophie

doi:10.3389/fimmu.2020.01409

Cited by 80 publications

(71 citation statements)

References 91 publications

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“…Moreover, we found that hydroxychloroquine could target TLR3 , -7 , and − 9 , which might render a potential immunomodulatory role in COVID-19 (Gies et al 2020 ). In the recent past, many drugs for the management of COVID-19 are currently under evaluation or development, of which, hydroxychloroquine remains the most controversial drug.…”

Section: Discussionmentioning

confidence: 98%

Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis

et al. 2021

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Section: Discussionmentioning

confidence: 98%

Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis

et al. 2021

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“…On the contrary, other studies have highlighted the ineffectiveness of these drugs both in the viremic phase and in respiratory complications (Boulware et al, 2020;Mahévas et al, 2020;Rosenberg et al, 2020). Although some data, both referring to COVID-19 and SARS, have highlighted some positive effects of CQ and HCQ in the evolution of the disease, thus showing their therapeutic potential, at the moment, there are no data that can support the use of these drugs to control the entire pathological process related to SARS-CoV-2 (Gies et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic Targets

et al. 2020

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Coronaviruses are enveloped, single-stranded, positive-sense RNA viruses that can infect animal and human hosts. The infection induces mild or sometimes severe acute respiratory diseases. Nowadays, the appearance of a new, highly pathogenic and lethal coronavirus variant, SARS-CoV-2, responsible for a pandemic (COVID-19), represents a global problem for human health. Unfortunately, only limited approaches are available to treat coronavirus infections and a vaccine against this new coronavirus variant is not yet available. The plasma membrane microdomain lipid rafts have been found by researchers to be involved in the replication cycle of numerous viruses, including coronaviruses. Indeed, some pathogen recognition receptors for coronaviruses as for other viruses cluster into lipid rafts, and it is therefore conceivable that the first contact between virus and host cells occurs into these specialized regions, representing a port of cell entry for viruses. Recent data highlighted the peculiar pro-viral or anti-viral role played by autophagy in the host immune responses to viral infections. Coronaviruses, like other viruses, were reported to be able to exploit the autophagic machinery to increase their replication or to inhibit the degradation of viral products. Agents known to disrupt lipid rafts, such as metil-β-cyclodextrins or statins, as well as autophagy inhibitor agents, were shown to have an anti-viral role. In this review, we briefly describe the involvement of lipid rafts and autophagy in coronavirus infection and replication. We also hint how lipid rafts and autophagy may represent a potential therapeutic target to be investigated for the treatment of coronavirus infections.

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“…Since, HCQ can cross the blood brain barrier, therefore, its usage can also be extended to the patient’s diagnose with the neurotransmission of the SARS-CoV2. The classical role of CQ and HCQ in inhibiting the reproduction cycle of the virus to its wide usage in Systemic lupus erythematosus (SLE) and other autoimmune diseases suggests a multipronged effect of CQ/HCQ on COVID-19 patients [ 69 ]. CQ can also inhibit complement system which has not been taken into consideration in case of COVID-19 infections.…”

Section: Old Bullets For New Target: Drugs For Mitigating the Symptommentioning

confidence: 99%

Decoding the silent walk of COVID-19: Halting its spread using old bullets

Kumar¹,

Madan²,

Sodhi³

et al. 2021

Biomedicine & Pharmacotherapy

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Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine

Cited by 80 publications

References 91 publications

Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis

Screening druggable targets and predicting therapeutic drugs for COVID-19 via integrated bioinformatics analysis

Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic Targets

Decoding the silent walk of COVID-19: Halting its spread using old bullets

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