Optical tweezers
have had a major impact on bioscience
research
by enabling the study of biological particles with high accuracy.
The focus so far has been on trapping individual particles, ranging
from the cellular to the molecular level. However, biology is intrinsically
heterogeneous; therefore, access to variations within the same population
and species is necessary for the rigorous understanding of a biological
system. Optical tweezers have demonstrated the ability of trapping
multiple targets in parallel; however, the multiplexing capability
becomes a challenge when moving toward the nanoscale. Here, we experimentally
demonstrate a resonant metasurface that is capable of trapping a high
number of nanoparticles in parallel, thereby opening up the field
to large-scale multiplexed optical trapping. The unit cell of the
metasurface supports an anapole state that generates a strong field
enhancement for low-power near-field trapping; importantly, the anapole
state is also more angle-tolerant than comparable resonant modes,
which allows its excitation with a focused light beam, necessary for
generating the required power density and optical forces. We use the
anapole state to demonstrate the trapping of 100’s of 100 nm
polystyrene beads over a 10 min period, as well as the multiplexed
trapping of lipid vesicles with a moderate intensity of <250 μW/μm2. This demonstration will enable studies relating to the heterogeneity
of biological systems, such as viruses, extracellular vesicles, and
other bioparticles at the nanoscale.