Metasurface-enhanced mid-infrared spectroscopy in the liquid phase

Abstract

Vibrational spectroscopy is an important tool in chemical and biological analysis. A key issue when applying vibrational spectroscopy to dilute liquid samples is the inherently low sensitivity caused by short...

Biomolecular infrared spectroscopy: making time for dynamics

“…Recently, surfaces based on Si nanostructures have shown potential to enhance signals from dilute solutions by an order of magnitude relative to IR absorption. 139 Such structures have a greater effective penetration depth of the enhancement into the sample (micron vs. nanometre) bringing potential applications for protein solutions within reach. Such systems exhibit a narrower resonance than observed for plasmonic structures however, restricting the size of the portion of the spectrum that can be enhanced.…”

Diabetes Monitoring through Urine Analysis Using ATR-FTIR Spectroscopy and Machine Learning

“…ATR-FTIR spectroscopy is capable of extracting intricate biochemical information from the vibrational energy inherent in chemical bonds found within biomolecules, such as lipids, nucleic acids, proteins, and carbohydrates when applied to liquid matrices [13][14][15]. This analytical technique ensures the detailed quantitative assessment of complicated biochemical samples, thus enabling the identification of the concentration of specific molecules [16]. Furthermore, it assists qualitative analysis through the examination of spectral disparities in characteristic bands of biomolecules related to the particular pathology under investigation.…”