Bidirectional Functions of Arsenic as a Carcinogen and an Anti-Cancer Agent in Human Squamous Cell Carcinoma

Thắng, Nguyễn Đình; Yajima, Ichiro; Kumasaka, Mayuko Y.; Kato, Masashi

doi:10.1371/journal.pone.0096945

Cited by 15 publications

(13 citation statements)

References 43 publications

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“…El análisis de riesgo de recurrencia muestra asociación con borde de sección histológico positivo, p = 0,001, OR 6,17; IC 95% (3,19) y la presencia de ulceración del tumor, p = 0,01, OR 4,63; IC 95% (1,45). No identificamos asociación entre recurrencia y características histológicas de alto riesgo de recidiva de enfermedad (alto grado histológico, invasión tumoral subcutánea e invasión perineural), p = 0,05 OR 0,46; IC 95% (0,21-1,01).…”

Section: Resultsunclassified

“…Este modo de clasificar los cánceres de piel se sustenta en la 7ª edición de la clasificación de tumores malignos de la American Join Comittee on Cancer de 2010 20 . Los tumores de alto riesgo incluyen alto grado histológico, invasión tumoral subcutánea, invasión perineural, tumores recurrentes y localización de alto riesgo: oreja, labio, sitio no expuesto al sol, aparición en úlcera crónica o cicatriz previa y tumor de más de 20 mm de diámetro 3,19,20 . Se considera de bajo riesgo aquellos que no presentan esos atributos.…”

Section: Recolección De Datos: Planilla Excelunclassified

“…Borde histológico positivo 0,001 6,17 (3,19) Ulceración del tumor 0,05 4,63 (1,45) Alto riesgo histólogico 0,05 0,46 (0,21-1,01)…”

Section: Factores De Recurrencia P Or-ic 95%unclassified

“…La base y el modelo para resolver el problema del cáncer de la piel es la cirugía 1,2 . Ambas enfermedades comparten el hecho que entre sus factores de riesgo más importantes se considera la exposición acumulativa a la radiación UV, la exposición a arsénico inorgánico, individuos de piel clara, piel dañada por el sol, la población mayor de 60 años e infecciones virales [3][4][5][6][7][8] . Comparten, además, que son localmente invasores pero, se distinguen en que el primero raramente genera metástasis y el segundo tiene ese potencial especialmente cuando se localiza en las orejas, labios y zonas cubiertas de piel, tumores que crecen en úlceras crónicas y tumores pobremente diferenciados 5 .…”

Section: Introductionunclassified

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Carcinoma de células escamosas de piel. Serie de casos

et al. 2018

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Introduction: Squamous skin cancer (SSC) is the second most frequent skin cáncer, nevertheless reports about this issue are not published in Chile. Objetive: To investigate social, demographics, and clinic characteristics of SSC in semidesertic Coquimbo Region, Chile. Material and Methods: serie of patients diagnosed and treated in Coquimbo hospital between January 2006 and December 2015. Inclussion criteria: 1.-histopathological confirmation of SSC. Exclusion criteria: 1.-follow up lesser than 12 months; 2.-operated in another hospital; 3.-submitted to another treatment prior to surgery; 4.-skin metastasis of mucous squamous carcinoma; 5.-patients with distant metástasis. Independent variables: age, gender, tumor site, tumor size, clinical lymph nodes, shore or valley residency. Dependent variable: recurrency frecuence, factors of recurrency, letality. Statistical analysis: descriptive and analytical by SSPS program.Results: 2.202 skin cancer cases were registered, 1.487 basal cells carcinoma (67.5%), 181 melanoma (8.2%) and 534 squamous cells carcinoma (24.2%). 236 patients with complete data are included in this report. There were 153 men (64.8%), and 83 women (35.2%). Mean age was 75.5 years old ± 11.7 (range 46-94). Primary site was: head 158 patients (66.9%), other sun exposed areas 47 patients (20%), and non exposed areas 31 patients. Cheek and front were the most frequents head site with 40 cases (25%) and 29 cases (12.3%), respectively. In 119 cases (50.4%) SCC was ulcerated, and 117 cases was not; primary tumor diameter was 22 millimeters (range 3-100). Clinical lymph nodes were primarily positives in 10 patients, (4.2%). In 12 cases with negative lymph nodes, sentinel limph node was resected. 2 were positives. Histological borders were tumor free in 201 patients (85.2%) and, 35 cases (14.8%) had positive histological borders. Local recurrence incidence was 8.5% (20 cases). Limph nodes recurrence was 2.1% (5 cases). Cancer recurrence was associated with histological positive borders P = 0.001, IC 95% 3.12-12.19, and ulcerated tumor p = 0.01, OR 4.63; IC 1.59-13.50. Letality was 2.56%. Mean follow up was 36 months (range 12-228 months). Conclusions: SSC has a good prognosis when primary tumor is resected early, with free histological borders resection.

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Section: Resultsunclassified

Section: Recolección De Datos: Planilla Excelunclassified

“…Borde histológico positivo 0,001 6,17 (3,19) Ulceración del tumor 0,05 4,63 (1,45) Alto riesgo histólogico 0,05 0,46 (0,21-1,01)…”

Section: Factores De Recurrencia P Or-ic 95%unclassified

Section: Introductionunclassified

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Carcinoma de células escamosas de piel. Serie de casos

et al. 2018

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“…60 Oxidative stress has also been connected with cancer as well as other benign diseases. 61 Research suggests that one of the most sensitive sites for arsenic exposure is the lungs. 55 The methylation of arsenic species to organic acids is considered to be connected to cancer in the lungs and the bladder.…”

Section: Properties Of Arsenic and Implications On Human Healthmentioning

confidence: 99%

Arsenic: A Review of the Element’s Toxicity, Plant Interactions, and Potential Methods of Remediation

Hettick

Cañas‐Carrell

French

et al. 2015

J. Agric. Food Chem.

144

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Arsenic is a naturally occurring element with a long history of toxicity. Sites of contamination are found worldwide as a result of both natural processes and anthropogenic activities. The broad scope of arsenic toxicity to humans and its unique interaction with the environment have led to extensive research into its physicochemical properties and toxic behavior in biological systems. The purpose of this review is to compile the results of recent studies concerning the metalloid and consider the chemical and physical properties of arsenic in the broad context of human toxicity and phytoremediation. Areas of focus include arsenic's mechanisms of human toxicity, interaction with plant systems, potential methods of remediation, and protocols for the determination of metals in experimentation. This assessment of the literature indicates that controlling contamination of water sources and plants through effective remediation and management is essential to successfully addressing the problems of arsenic toxicity and contamination.

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Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology

et al. 2014

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The cell cycle inhibitor p21(CDKN1A) is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent kinases. In addition, p21 is involved in the regulation of transcription, apoptosis, DNA repair, as well as cell motility. However, p21 appears to a have a dual-face behavior because, in addition to its tumor suppressor functions, it may act as an oncogene, depending on the cell type and on the cellular localization. As a biomarker of the cell response to different toxic stimuli, p21 expression and functions have been analyzed in an impressive number of studies investigating the activity of several types of chemicals, in order to determine their possible harmful effects on human cells. Here, we review these studies in order to highlight the different roles p21 may play in the cell response to chemical exposure and to better evaluate the information provided by this biomarker.

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Bidirectional Functions of Arsenic as a Carcinogen and an Anti-Cancer Agent in Human Squamous Cell Carcinoma

Cited by 15 publications

References 43 publications

Carcinoma de células escamosas de piel. Serie de casos

Carcinoma de células escamosas de piel. Serie de casos

Arsenic: A Review of the Element’s Toxicity, Plant Interactions, and Potential Methods of Remediation

Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology

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