Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections

Ma, Yao‐Ying; Lee, Brian; Wang, Xiusong; Guo, Chunmei; Liu, Lei; Cui, Ranji; Liu, Yan; Balcita-Pedicino, Judith Joyce; Wolf, Marina E.; Sesack, Susan R.; Shaham, Yavin; Schlüter, Oliver M.; Huang, Yanhua H.; Dong, Yi

doi:10.1016/j.neuron.2014.12.004

Cited by 41 publications

(67 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Dong and colleagues showed that silentsynapse-based manipulations of the BLA or dmPFC (prelimbic cortex) projections to accumbens shell or core, respectively, decreased incubated cue-induced cocaine seeking during late withdrawal (Lee et al, 2013;Ma et al, 2014). In contrast, reversible inactivation of BLA or dmPFC with muscimol þ baclofen had no effect on incubation of methamphetamine (present study) or cocaine (Koya et al, 2009) craving.…”

Section: Methodological Considerationssupporting

confidence: 37%

“…In contrast, reversible inactivation of BLA or dmPFC with muscimol þ baclofen had no effect on incubation of methamphetamine (present study) or cocaine (Koya et al, 2009) craving. However, direct comparison between our results and the results by Dong and colleagues (Lee et al, 2013;Ma et al, 2014) should be made with caution because of several notable differences in experimental procedures. We used extended daily drug access (6-9 h/day) and adultonset drug self-administration, while Dong and colleagues used limited drug access (2 h/day) and juvenile-onset selfadministration.…”

Section: Methodological Considerationsmentioning

confidence: 47%

“…Furthermore, the dmPFC (comprised of anterior cingulate and dorsal part of prelimbic cortices) has been established as a critical brain region for cue-induced reinstatement of drug seeking Feltenstein and See, 2008). Recent studies also implicate the projection from this brain area to NAc in incubation of cocaine craving (Ma et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Central Amygdala Nucleus is Critical for Incubation of Methamphetamine Craving

Zeric

Kambhampati

et al. 2014

Neuropsychopharmacol

Self Cite

148

View full text Add to dashboard Cite

Cue-induced methamphetamine seeking progressively increases after withdrawal but mechanisms underlying this 'incubation of methamphetamine craving' are unknown. Here we studied the role of central amygdala (CeA), ventral medial prefrontal cortex (vmPFC), and orbitofrontal cortex (OFC), brain regions implicated in incubation of cocaine and heroin craving, in incubation of methamphetamine craving. We also assessed the role of basolateral amygdala (BLA) and dorsal medial prefrontal cortex (dmPFC). We trained rats to self-administer methamphetamine (10 days; 9 h/day, 0.1 mg/kg/infusion) and tested them for cue-induced methamphetamine seeking under extinction conditions during early (2 days) or late (4-5 weeks) withdrawal. We first confirmed that 'incubation of methamphetamine craving' occurs under our experimental conditions. Next, we assessed the effect of reversible inactivation of CeA or BLA by GABAA+GABAB receptor agonists (muscimol+baclofen, 0.03+0.3 nmol) on cue-induced methamphetamine seeking during early and late withdrawal. We also assessed the effect of muscimol+baclofen reversible inactivation of vmPFC, dmPFC, and OFC on 'incubated' cue-induced methamphetamine seeking during late withdrawal. Lever presses in the cue-induced methamphetamine extinction tests were higher during late withdrawal than during early withdrawal (incubation of methamphetamine craving). Muscimol+baclofen injections into CeA but not BLA decreased cue-induced methamphetamine seeking during late but not early withdrawal. Muscimol+baclofen injections into dmPFC, vmPFC, or OFC during late withdrawal had no effect on incubated cue-induced methamphetamine seeking. Together with previous studies, results indicate that the CeA has a critical role in incubation of both drug and non-drug reward craving and demonstrate an unexpected dissociation in mechanisms of incubation of methamphetamine vs cocaine craving.

show abstract

Section: Methodological Considerationssupporting

confidence: 37%

Section: Methodological Considerationsmentioning

confidence: 47%

See 1 more Smart Citation

The Central Amygdala Nucleus is Critical for Incubation of Methamphetamine Craving

Zeric

Kambhampati

et al. 2014

Neuropsychopharmacol

Self Cite

148

View full text Add to dashboard Cite

show abstract

“…Optogenetically driving cortico-striatal projections suppresses pathological grooming in a model of obsessive compulsive disorder [41], whereas activation of cortico-striatal projections at frequencies known to induce an LTD cause pathological grooming in wild-type mice [42]. In models of addiction, applying LTD protocols at excitatory synapses in the nucleus accumbens reverses cocaine-evoked potentiation of excitatory transmission and addiction-related behavior, as discussed above [26,[28][29][30]. Applying LTD protocols at inputs from the basolateral amygdala or ventral hippocampus reduced responding for cocaine after withdrawal from self-administration (Figures 1 and 2).…”

Section: H Z Current Opinion In Neurobiologymentioning

confidence: 99%

“…Interestingly, the two changes are carried by specific inputs, increased AMPA/NMDA ratio is a feature of afferents from the ventral hippocampus, while rectification appears selectively at the medial prefrontal cortex (mPFC) inputs [28]. At this mPFC input, unsilencing of synapses containing only NMDARs by insertion of GluA2-lacking AMPAR may contribute to the increase in rectification [29,30].…”

Section: The Synapse As Site Of Pathology In Addictionmentioning

confidence: 99%

Optogenetic dissection of neural circuitry: from synaptic causalities to blue prints for novel treatments of behavioral diseases

Lüscher

Pascoli

Creed

2015

Current Opinion in Neurobiology

View full text Add to dashboard Cite

Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptor

Zhang

Song

Dai

et al. 2022

MedComm

View full text Add to dashboard Cite

Opioid abuse and addiction have become a global pandemic, posing tremendous health and social burdens. The rewarding effects and the occurrence of withdrawal symptoms are the two mainstays of opioid addiction. Mu‐opioid receptors (MORs), a member of opioid receptors, play important roles in opioid addiction, mediating both the rewarding effects of opioids and opioid withdrawal syndrome (OWS). The underlying mechanism of MOR‐mediated opioid rewarding effects and withdrawal syndrome is of vital importance to understand the nature of opioid addiction and also provides theoretical basis for targeting MORs to treat drug addiction. In this review, we first briefly introduce the basic concepts of MORs, including their structure, distribution in the nervous system, endogenous ligands, and functional characteristics. We focused on the brain circuitry and molecular mechanism of MORs‐mediated opioid reward and withdrawal. The neuroanatomical and functional elements of the neural circuitry of the reward system underlying opioid addiction were thoroughly discussed, and the roles of MOR within the reward circuitry were also elaborated. Furthermore, we interrogated the roles of MORs in OWS, along with the structural basis and molecular adaptions of MORs‐mediated withdrawal syndrome. Finally, current treatment strategies for opioid addiction targeting MORs were also presented.

show abstract

Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections

Cited by 41 publications

References 0 publications

The Central Amygdala Nucleus is Critical for Incubation of Methamphetamine Craving

The Central Amygdala Nucleus is Critical for Incubation of Methamphetamine Craving

Optogenetic dissection of neural circuitry: from synaptic causalities to blue prints for novel treatments of behavioral diseases

Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptor

Contact Info

Product

Resources

About