Biliary Excretion of Cadmium

Abstract

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Pulmonary and gastrointestinal exposure to cadmium oxide dust in a battery factory.

“…Cadmium oxide dust inhaled from air will be deposited in the respiratory tract and part of the deposited cadmium will be absorbed from the alveoli, whereas the rest will be transferred to a large extent to the gastrointestinal tract via mucociliary clearance from the lung followed by swallowing 'r the mucus containing the cadmium. In the present study all workers were exposed to relatively low concentrations of cadmium in air, [2][3][4][5][6][7][8][9][10][11][12][13][14][15] ,g/m3, and even assuming a daily inhalation of 10 m3 of air and 50%o deposition, amounts of less than 75 ,ug can be expected to have been transferred to the gut from the lungs.…”

Probing the coordination behavior of Hg2+, CH3Hg+, and Cd2+ towards mixtures of two biological thiols by HPLC-ICP-AES

“…With regard to Hg 2+ , CH 3 Hg + and Cd 2+ , their excretion in bile has been identified as a major excretory route in mammals [27][28][29][30][31]. Given that each of these metal species have a high chemical affinity for thiol-groups and considering that the endogenous thiol GSH is present in hepatocyte cytosol at~5.0 mM [32,33], it is not surprising that Hg 2+ , CH 3 Hg + and Cd 2+ are excreted into bile in form of their corresponding GS-complexes [27,29,[34][35][36].…”

Strong positive association of traditional Asian-style diets with blood cadmium and lead levels in the Korean adult population

“…For example, some studies have reported that cadmium and lead are excreted mostly though urine, but others have reported that they are eliminated equally through urine and feces (Satarug and Moore 2004;Vahter et al 1992;O'Flahertya et al 1996). Most investigators believe that their excretion is mainly through urine; however, fecal excretion through bile cannot be ignored (McKenzie-Parnell et al 1988;Elinder and Pannone 1979). Intoxication with cadmium might be predominantly due to its exposure and absorption, not excretion, whereas lead toxicity can be affected by the combination of exposure, absorption, and excretion.…”