Bilirubin

Perlman, Jeffrey M.; Volpe, Joseph J.

doi:10.1016/b978-0-323-42876-7.00026-0

Cited by 8 publications

(3 citation statements)

References 169 publications

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“…In a healthy human, all bilirubin molecules produced from hemoglobin are bound by human serum albumin (HSA) and transported to the liver, where these complexes turn into mono-conjugates (bilirubin glucuronides) and are excreted into the bile. 12,13 Different kinds of disorders may lead to an increase in the levels of unconjugated bilirubin, especially in the neonatal period. Usually, it happens because of the reduced activity of an enzyme uridine diphosphoglucuronosyltransferase 1A1 (UGT1A1).…”

Section: Introductionmentioning

confidence: 99%

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation

Perkov¹,

Gorin²

2023

Phys. Chem. Chem. Phys.

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Section: Introductionmentioning

confidence: 99%

Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation

Perkov¹,

Gorin²

2023

Phys. Chem. Chem. Phys.

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“…Bilirubin is produced in the reticuloendothelial system as an end‐product of haem catabolism . High serum bilirubin, or hyperbilirubinaemia, results from disorders that occur in any of the multiple steps of conjugation and excretion . In individuals with profound hyperbilirubinaemia, increased bilirubin filtration may lead to the formation of bile casts .…”

Section: Introductionmentioning

confidence: 99%

Role of inflammation and inflammasome activation in human bile cast nephropathy

et al. 2020

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Bile cast nephropathy (BCN) is an underdiagnosed cause of acute kidney injury (AKI).The precise pathogenesis of bilirubin tubular toxicity remains unknown. The aim of this study is to explore the cellular and molecular pathophysiology of human BCN.Paraffin-embedded sections of renal biopsy tissue from a BCN patient were stained by immunohistochemistry (IHC) for oxidative stress (4-hydroxynonenal), immune cell subpopulations, including dendritic cells (CD1c), macrophages (CD68) and T cells (CD3), and inflammasome activation by staining for active-caspase-1 and the inflammasome adaptor protein, ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain). Quantitative analyses of IHC staining were com-

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“…There is wide disparity in the bilirubin thresholds used for phototherapy among neonatal centres across the globe 6 . The bilirubin levels at which neurotoxicity is reported in the literature are also highly variable 15 16 17 .…”

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confidence: 99%