This study aims to determine the significant effect of the total physical response (TPR) method on the mastery of English vocabulary in children in group B Diponegoro Kindergarten. Mastery of English vocabulary is a foreign language ability in children to hear English vocabulary, understand English vocabulary and their meanings, remember English vocabulary that is heard, and physically practice English vocabulary that is understood according to the commands given. This type of research is quasi-experimental research with a non-equivalent control group design. This study population consisted of all group B of Diponegoro Kindergarten, Buleleng Subdistrict, Buleleng Regency, totalling 69 people. The sampling technique uses the cluster sampling technique. This study's sample was children of Diponegoro Kindergarten B1 group of 17 children as the experimental group and B2 Diponegoro Kindergarten children of 19 children as the control group. Data collection techniques are observation techniques using observation guide sheets. The data obtained were analyzed using descriptive statistical analysis and inferential statistical analysis with a t-test. Based on the results of data analysis, the results of the t-test are tcount = 15.093 and ttable with a significant level of 5% at a degree of freedom (db) 34 is 2.032. T-test results show that tcount > ttable, then H0 is rejected, and HA is accepted. Based on the results of the study, which stated the differences between the control class and the experimental class, so it can be concluded that there is a significant influence on the application of the total physical response (TPR) learning method to the mastery of English vocabulary in children in B group Diponegoro Kindergarten, Buleleng District, Buleleng Regency 2019/2020 lesson..