Bimetallic Organic Frameworks of High Piezovoltage for Sono‐Piezo Dynamic Therapy

Abstract

Piezoelectric materials produce charges to directly act on cancer medium or promote reactive oxygen species (ROS) generation for novel tumor therapy triggered by sonography. Currently, piezoelectric sonosensitizers are mainly used to catalyze ROS generation by band‐tilting effect for sonodynamic therapy. However, it remains a challenge for piezoelectric sonosensitizers to produce high piezo‐voltages to overcome the band‐gap barrier for direct charge generation. Herein, the Mn‐Ti bimetallic organic framework tetragonal nanosheets (MT‐MOF TNS) are designed to produce high piezo‐voltages for novel sono‐piezo dynamic therapy (SPDT) with remarkable antitumor efficacy in vitro and in vivo. MT‐MOF TNS content non‐centrosymmetric secondary building units of Mn‐Ti‐oxo cyclic octamers with charge heterogeneous components for piezoelectricity. MT‐MOF TNS promote strong sono‐cavitation to insitu induce piezoelectric effect with a high sono‐piezo (SP) voltage (2.9 V) to directly excite charges, which is validated by sono‐piezo‐excited luminescence spectrometry. The SP voltage and charges depolarize the mitochondrial and plasma membrane potentials, and cause ROS overproduction and serious tumor cell damage. Importantly, MT‐MOF TNS can be decorated with targeting molecules and chemotherapeutics for more severe tumor regression by combining SPDT with chemodynamic therapy and chemotherapy. This report develops a fascinating MT‐MOF piezoelectric nano‐semiconductor and provides an efficient SPDT strategy for tumor treatment.This article is protected by copyright. All rights reserved

Near-Infrared-II-Activatable Self-Assembled Manganese Porphyrin-Gold Heterostructures for Photoacoustic Imaging-Guided Sonodynamic-Augmented Photothermal/Photodynamic Therapy

“…Therefore, a possible mechanism was proposed (Figure i), under US or 1064 nm light irradiation, electrons of Au NPs transferred to the SM NPs. Simultaneously, the photogenerated or sound-generated carriers generated inside the SM NPs are separated by the built-in electric field, transmitted through the π–π channel, and reached on the surface of the SM NPs in the end. ,, The generated electrons can convert O 2 into intermediate superoxide anion radicals ( • O 2 – ), and then the generated holes can further oxidize • O 2 – to 1 O 2 . − The SMA heterostructures significantly enhances the separation of electrons and holes and improves catalytic efficiency.…”

A metal–organic framework-integrated composite for piezocatalysis-assisted tumour therapy: design, related mechanisms, and recent advances

“…For example, Wang et al prepared Mn–Ti bimetallic organic framework tetragonal nanosheets (MT-MOF-TNSs). 63 A novel sono-piezo dynamic therapy (SPDT) of the MT-MOF-TNS was proposed for the treatment of tumours (Fig. 5).…”

Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy

“…Recently, different research groups have reported pioneering examples of MOFs themselves as efficient nanocatalysts and theranostic agents. 122–132 According to the function roles of MOFs in the construction of CDT agents, two categories of MOF-based nanocatalysts will be summarized in this part. The first section will elaborate on MOFs as nanocarriers of CDT agents by in situ hybridization or post-synthetic modification.…”

“…For example, Wang and coworkers recently reported a Mn-Ti bimetallic MOF (MT-MOF) with non-centrosymmetric SBUs for novel sono-piezo-chemo-dynamic therapy, which is constructed by incorporating Mn elements in the SBUs of a tetragonal Ti-MOF. 128 The formed non-centrosymmetric SBUs of hybrid Mn-Ti-oxo cyclic octamer were effective electric dipoles with heterogeneous charge distribution, which enables MT-MOF to generate a strong sono-piezoelectricity under a low-intensity ultrasound. Specifically, such piezoelectric MT-MOF can convert sonomechanics into electricity to produce a high piezovoltage to excite charges, which depolarize the mitochondrial and plasma membrane potentials and lead to abundant ROS production for novel sono-piezo-dynamic therapy with remarkable antitumor efficacy.…”