Binding and potential-triggered release of l-glutamate with molecularly imprinted polypyrrole in neutral pH solutions

Chernov, Ivan; Greb, Helena; Janssen‐Bienhold, Ulrike; Parisi, J.; Weiler, Reto; Hauff, Elizabeth von

doi:10.1016/j.snb.2014.06.030

Cited by 12 publications

(9 citation statements)

References 33 publications

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“…The mechanism of uptake is similar to the findings of Paul et al. [ 21 ]. They studied uptake and reverse uptake processes using a molecularly imprinted polymer (MIP) and found a relationship between glutamate concentration and voltage pulse on the MIP electrode.…”

Section: Resultssupporting

confidence: 90%

“…A molecular imprinting method was previously introduced for neurotransmitter uptake into an over-oxidized conducting polymer. However, this method requires pretreatment of polypyrrole, which includes oxidizing and exchanging ions [ 21 , 22 , 23 ]. Therefore, this study proposes an easier uptake method for a neurotransmitter using carbon-based materials.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

On-chip testing of a carbon-based platform for electro-adsorption of glutamate

Whulanza

Arafat

Rahman

et al. 2022

Heliyon

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

On-chip testing of a carbon-based platform for electro-adsorption of glutamate

Whulanza

Arafat

Rahman

et al. 2022

Heliyon

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“…The obtained value of Gibbs free energy change is in the same order as that value calculated by other authors [28] and confirmed in our previous works [27]. These values are close to that which are typical for 2-3 hydrogen bounds formation and electrostatic interactions [29,30].…”

Section: Evaluation Of Theophylline Interaction With Mip-ppysupporting

confidence: 91%

Evaluation of theophylline imprinted polypyrrole film

et al. 2015

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“…In addition, comparison of the dissociation constants, Kds, derived from binding kinetics might shed light on binding affinity between IgG and the synthesized IgG‐MIPs . The calculated Kd values (3.1nM, 4.8nM, and 5.0nM for IgG‐MI‐PmPD, IgG‐MI‐PDA, and IgG‐MI‐PEDOT, respectively) were in consistence with the conclusions above, demonstrating somewhat higher binding affinity of IgG to IgG‐MI‐PmPD.…”

Section: Resultsmentioning

confidence: 99%

A computational approach to study functional monomer-protein molecular interactions to optimize protein molecular imprinting

et al. 2017

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Molecular imprinting has become a promising approach for synthesis of polymeric materials having binding sites with a predetermined selectivity for a given analyte, the so-called molecularly imprinted polymers (MIPs), which can be used as artificial receptors in various application fields. Realization of binding sites in a MIP involves the formation of prepolymerization complexes between a template molecule and monomers, their subsequent polymerization, and the removal of the template. It is believed that the strength of the monomer-template interactions in the prepolymerization mixture influences directly on the quality of the binding sites in a MIP and consequently on its performance. In this study, a computational approach allowing the rational selection of an appropriate monomer for building a MIP capable of selectively rebinding macromolecular analytes has been developed. Molecular docking combined with quantum chemical calculations was used for modeling and comparing molecular interactions among a model macromolecular template, immunoglobulin G (IgG), and 1 of 3 electropolymerizable functional monomers: m-phenylenediamine (mPD), dopamine, and 3,4-ethylenedioxythiophene, as well as to predict the probable arrangement of multiple monomers around the protein. It was revealed that mPD was arranged more uniformly around IgG participating in multiple H-bond interactions with its polar residues and, therefore, could be considered as more advantageous for synthesis of a MIP for IgG recognition (IgG-MIP). These theoretical predictions were verified by the experimental results and found to be in good agreement showing higher binding affinity of the mPD-based IgG-MIP toward IgG as compared with the IgG-MIPs generated from the other 2 monomers.

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Binding and potential-triggered release of l-glutamate with molecularly imprinted polypyrrole in neutral pH solutions

Cited by 12 publications

References 33 publications

On-chip testing of a carbon-based platform for electro-adsorption of glutamate

On-chip testing of a carbon-based platform for electro-adsorption of glutamate

Evaluation of theophylline imprinted polypyrrole film

A computational approach to study functional monomer-protein molecular interactions to optimize protein molecular imprinting

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