Binding of Excreted and/or Secreted Products of Adult Hookworms to Human NK Cells in<i>Necator americanus</i>-Infected Individuals from Brazil

Teixeira-Carvalho, Andréa; Fujiwara, Ricardo Toshio; Stemmy, Erik J.; Olive, D; Damsker, Jesse M.; Loukas, Alex; Corrêa-Oliveira, Rodrigo; Constant, Stephanie L.; Bethony, Jeffrey M.

doi:10.1128/iai.00419-08

Cited by 19 publications

(17 citation statements)

References 30 publications

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“…Chronic helminth infections induce potent immunoregulatory pathways (30–32), such as immunosuppressive cytokines [e.g. IL-10 or TGF-β (33, 34)] or regulatory T cell populations (35, 36) that may facilitate parasite survival.…”

Section: Discussionmentioning

confidence: 99%

Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection

Gazzinelli-Guimarães

Bonne-Année

Fujiwara

et al. 2016

The Journal of Immunology

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Among the various hypotheses put forward to explain the modulatory influence of helminth infection on allergic effector responses in humans, the IL-10 induced suppression of Th2-associated responses has been the leading candidate. To explore this helminth/allergy interaction more fully, parasite- and allergen--specific T cell responses CD4+ T cell responses in 12 subjects with filarial infections and coincident allergic sensitization (Fil+A+) were compared these to the responses to 3 appropriate control groups [Fil−A− (n=13), Fil−A+(n=12), Fil+A−(n=11)]. The most important findings revealed that Fil+A+ had marked (p<0001 for all cytokines) increases in parasite antigen-driven Th2 (IL-4, IL-5, IL-13), Th9 (IL-9) and the regulatory (IL-10) cytokines when compared with Fil+A−. Moreover, using multiparameter flow cytometry, filarial parasite antigen induced a marked increase in not only the frequency of CD4+ T cells producing IL-4, IL-5, IL-2 and TNF-α in Fil+A+ when compared to Fil+A− patients but also in the frequencies of polyfunctional Th2-like (CD4+IL-4+IL-5+ and CD4+IL-2+IL-4+IL-5+TNF-α+) cells. The Th2-associated responses seen in the Fil+A+ group was correlated with serum IgE levels (p<0.01, r=0.5165 for IL-4; p<0.001, r=0.5544 for IL-5; and, p<0.001, r=0.4901 for IL-13), levels of circulating eosinophils (p<0.0116, r=0.5656) and their degranulation/activation products [major basic protein (p<0.001, r=0.7353) and, eosinophil derived neurotoxin (p<0.01, r=0.7059)]. CD4+ responses to allergen were not different (to a large extent) among the groups. Taken together, our data suggest that allergic sensitization coincident with filarial infection drives parasite antigen-specific T cell hyperresponsiveness, characterized largely by an augmented Th2-dominated immune response.

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Section: Discussionmentioning

confidence: 99%

Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection

Gazzinelli-Guimarães

Bonne-Année

Fujiwara

et al. 2016

The Journal of Immunology

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“…The infection status of the host seemed to influence the binding capacity of NK cells to the adult ES since infected individuals showed negligible binding in comparison to negative endemic and non-endemic individuals, although the NK cells from infected individuals demonstrated a higher production of IFN-g. This data suggest that during hookworm infection, NK cells are called into the infection site by chemoattractants and that infected individuals have saturated receptors which block any further binding [41].…”

Section: Mechanisms Of Down-regulation In Hookworm and Hookworm-relatmentioning

confidence: 93%

Hookworm virulence factors: making the most of the host

Periago

Bethony

2012

Microbes and Infection

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“…Hookworm infection also affects NK cells, with a larger number of NK cells in the circulation of infected individuals. These NK cells appear activated as they spontaneously produce IFN‐γ in culture (48). NaES acts as a chemoattractant for NK cells and also binds to a subset of NK cells, directly inducing IFN‐γ release (49).…”

Section: Cellular Responses To Hookwormmentioning

confidence: 99%

The immunology of human hookworm infections

McSorley

Loukas

2010

Parasite Immunology

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Hookworms are one of the most prevalent parasites of humans in developing countries, but we know relatively little about the immune response generated to hookworm infection. This can be attributed to a lack of permissive animal models and a relatively small research community compared with those of the more high-profile parasitic diseases. However, recently, research has emerged on the development of vaccines to control hookworm infection and the use of hookworm to treat autoimmune and allergic disorders, contributing to a greater understanding of the strategies used by hookworms to modulate the host's immune response. A substantial body of research on the immunobiology of hookworms originates from Australia, so this review will summarize the current status of the field with a particular emphasis on research carried out 'down under'.

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Binding of Excreted and/or Secreted Products of Adult Hookworms to Human NK Cells inNecator americanus-Infected Individuals from Brazil

Abstract: The impact of the interaction between excreted and/or secreted (ES)Necator

Cited by 19 publications

References 30 publications

Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection

Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection

Hookworm virulence factors: making the most of the host

The immunology of human hookworm infections

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