Binding of IgG and other proteins to microfilters.

Walsh, Robert L.; Coles, M E

doi:10.1093/clinchem/26.3.496

Cited by 15 publications

(4 citation statements)

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“…I t is suggested that a saturation of binding sites of these hydrophilic filters might be the reason why adsorption stops. T h e same phenomenon is observed by Walsh & Coles in studying binding of immunoglobulins to microfilters (19). T h e loss of the investigated drugs by filtration is only temporary and returns to a 100°, recovery value.…”

Section: R E S U L T S a N D Discussionsupporting

confidence: 80%

Binding of Drugs to End-Line Filters: A Study of Four Commonly Administered Drugs in Intensive Care Units

et al. 1988

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The binding of diazepam, digoxin, dopamine and fentanyl to different 0.2 microns end-line filters was investigated under simulated infusion conditions. All the drugs were diluted in either 5% dextrose or 0.9% NaCl infusion fluid. For digoxin and diazepam a marked reduction in the amount of drug delivered to the patient in the first 20-60 min of infusion is observed. For dopamine, the drug loss was less pronounced and no fentanyl was absorbed to the filters during the infusion experiment.

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Section: R E S U L T S a N D Discussionsupporting

confidence: 80%

Binding of Drugs to End-Line Filters: A Study of Four Commonly Administered Drugs in Intensive Care Units

et al. 1988

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“…Similar binding between neutral molecules, for instance proteinaceous and cellulose filters, was described in an earlier work, which lists the following hierarchy of adsorption to filter materials: cellulose nitrate > mixed cellulose esters > cellulose diacetate > cellulose triacetate. The study with IgG (immunoglobulin) G, A, and M; albumin; transferrin; and other proteins’ adsorption confirms the fact that cellulose nitrate adsorbs the most strongly. One explanation is that IgG has a configuration that allows binding to the chemical structure of the filter material.…”

Section: Results and Discussionsupporting

confidence: 55%

Role of the Filters in the Formation and Stabilization of Semiquinone Radicals Collected from Cigarette Smoke

2013

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The fractional pyrolysis of Bright tobacco was performed in nitrogen atmosphere over the temperature range of 240 – 510 °C in a specially constructed, high temperature flow reactor system. Electron paramagnetic resonance (EPR) spectroscopy was used to analyze the free radicals in the initially produced total particular matter (TPM) and in TPM after exposure to ambient air (aging). Different filters have been used to collect TPM from tobacco smoke: cellulosic, cellulose nitrate, cellulose acetate, nylon, Teflon and Cambridge. The collection of the primary radicals (measured immediately after collection of TPM on filters), the formation and stabilization of the secondary radicals (defined as radicals formed during aging of TPM samples on the filters) depend significantly on the material of the filter. A mechanistic explanation about different binding capability of the filters decreasing in the order: cellulosic < cellulose nitrate < cellulose acetate < nylon ~ teflon is presented. Different properties were observed for the Cambridge filter. Specific care must be taken using the filters for identification of radicals from tobacco smoke to avoid artifacts in each case.

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“…Walsh et al 48 observed that cellulose-nitrate-containing filters remove IgG and to a lesser extent IgA and IgM, but there was no significant adsorption of albumin or transferrin by any of the filters studied. If the filters were pre-washed with polyethylene glycol, IgG adsorption was not seen.…”

Section: Absorption Of Proteinsmentioning

confidence: 89%

Filters in Anaesthesia and Intensive Care

Tyagi

Kumar

Bhattacharya

et al. 2003

Anaesth Intensive Care

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The use of various types of filters in anaesthesia and intensive care seems ubiquitous, yet authentication of the practice is scarce and controversies abound. This review examines evidence for the practice of using filters with blood and blood product transfusion (standard blood filter, microfilter, leucocyte depletion filter), infusion of fluids, breathing systems, epidural catheters, and at less common sites such as with Entonox inhalation in non-intubated patients, forced air convection warmers, and air-conditioning systems. For most filters, the literature failed to support routine usage, despite this seemingly being popular and innocuous. The controversies, as well as guidelines if available, for each type of filter, are discussed. The review aims to rationalize the place of various filters in the anaesthesia and intensive care environment.

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Binding of IgG and other proteins to microfilters.

Cited by 15 publications

References 0 publications

Binding of Drugs to End-Line Filters: A Study of Four Commonly Administered Drugs in Intensive Care Units

Binding of Drugs to End-Line Filters: A Study of Four Commonly Administered Drugs in Intensive Care Units

Role of the Filters in the Formation and Stabilization of Semiquinone Radicals Collected from Cigarette Smoke

Filters in Anaesthesia and Intensive Care

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