Binding of [&lt;sup&gt;3&lt;/sup&gt;H]lysergic Acid Diethylamide to Serotonin 5-HT&lt;sub&gt;2A&lt;/sub&gt; Receptors and of [&lt;sup&gt;3&lt;/sup&gt;H]paroxetine to Serotonin Uptake Sites in Platelets from Healthy Children, Adolescents and Adults

Sigurdh, Jeanette; Spigset, Olav; Allard, Per; Mjörndal, Tom; Hägglöf, Bruno

doi:10.1159/000026617

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…This preliminary investigation did not attempt to compare diagnosis-dependent differences for 5-HT transporter measures. However, the Bmax values were comparable with reports from impulsive and non-impulsive adult suicide attempters (Verkes et al 1998), normal 11-12 year-old male and female children (Sigurdh et al 1999) and adolescents with conduct disorder (Unis et al 1997). The Kd values were also comparable, except that the median value cited by Sigurdh et al was somewhat lower, probably reflecting minor methodological differences (pers.…”

Section: Discussionsupporting

confidence: 78%

Serotonin Platelet-Transporter Measures in Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Clinical versus Experimental Measures of Impulsivity

Oades

Slusarek

Velling

et al. 2002

The World Journal of Biological Psychiatry

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Impulsivity in terms of aggression, suicide or poor cognitive control has been associated with low synaptic availability of serotonin (5-HT) in adults and children. However, characteristics of the 5-HT transporter have not been studied in children with attention-deficit/hyperactivity disorder (ADHD: combined type), where impulsivity is a core symptom. Here, we explored in 20 children with ADHD the relationship of the density (Bmax) and affinity (Kd) of the platelet 5-HT transporter measured with [3H]paroxetine to both clinical ratings of impulsivity (Conners' Parent Questionnaire), and an experimental measure of impulsivity (the ability to withhold a prepotent response in the "stop-signal" paradigm). Decreases of affinity (increased Kd) correlated with a low probability of response inhibition, but not with the clinical ratings of impulsivity. However, ratings of distractibility and impulsivity correlated with the experimental measure of response-inhibition. In contrast, increased transporter affinity (low Kd) correlated modestly with higher ratings of aggressive and externalising behaviour. Bmax was not associated with any behavioural score. We conclude that the synaptic availability of 5-HT is under the control of the 5-HT transporter binding site affinity and that low affinity may be related to cognitive impulsivity (distractibility). Increased affinity of the transporter may also be related to conduct disturbance.

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Section: Discussionsupporting

confidence: 78%

Serotonin Platelet-Transporter Measures in Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Clinical versus Experimental Measures of Impulsivity

Oades

Slusarek

Velling

et al. 2002

The World Journal of Biological Psychiatry

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“…Notably, in a study in healthy volunteers, there was a decrease in [ 3 H]LSD binding densities between 11-12 and 16-17 years, and a decrease in [ 3 H]paroxetine binding densities after the ages of 16-17 years [29]. In that study, there were no gender differences in any of the age groups, reducing the possibility that alterations in the levels of female sex hormones could explain the observed age-related changes.…”

Section: Discussionmentioning

confidence: 72%

Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders

Sigurdh¹,

Allard²,

Spigset³

et al. 2013

International Journal of Neuroscience

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The pathogenetic involvement of the serotonergic system in eating disorders is an established finding. Conclusions from platelet studies are based on results from investigations of subjects with a mean age of 20 years or more. The aim was to investigate whether previous findings in adults are valid also for adolescents who are examined within a relatively short interval after the onset of the eating disorder. [(3)H]paroxetine binding to the platelet serotonin transporter and [(3)H]lysergic acid diethylamide ([(3)H]LSD) binding to the 5-HT2A receptor was studied in 15 female adolescents with eating disorders (11 with anorexia nervosa and 4 with clearly anorectic eating behaviour not fulfilling the criteria for anorexia nervosa) and 32 controls. The patients revealed a higher density of serotonin transporters and a lower density of 5-HT2A receptors compared with healthy controls of the same age (775 ± 165 vs. 614 ± 111 fmol/mg protein (p = 0.003) for [(3)H]paroxetine binding and 215 ± 59 vs. 314 ± 151 fmol/mg protein (p = 0.005) for [(3)H]LSD binding). The findings of increased density of platelet serotonin transporters and reduced density of 5-HT2A receptors differ from previous results in older patients. The lower patient age and the short duration of disease in the present study, possibly in conjunction with variations in stress-related psychological and biological factors, may have caused these differences. Although the present findings contradict prevailing evidence, they add further information concerning the nature of serotonergic involvement in eating disorders and indicate that demographic and course-related factors might influence the regulation of the serotonin system in these disorders.

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“…Human studies (platelet binding, postmortem reports) suggest that from the age of 10y, certainly from adolescence, 5-HT turnover and binding for 5-HT2a and transporter sites decrease markedly (71)(72)(73). Indeed an associated down-regulation of 5-HT2a sites has been monitored electrophysiologically (74).…”

Section: Htmentioning

confidence: 99%

The Roles of Norepinephrine and Serotonin in Attention Deficit Hyperactivity Disorder

Oades

2005

Contemporary Clinical Neuroscience

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Binding of [<sup>3</sup>H]lysergic Acid Diethylamide to Serotonin 5-HT<sub>2A</sub> Receptors and of [<sup>3</sup>H]paroxetine to Serotonin Uptake Sites in Platelets from Healthy Children, Adolescents and Adults

Cited by 4 publications

References 22 publications

Serotonin Platelet-Transporter Measures in Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Clinical versus Experimental Measures of Impulsivity

Serotonin Platelet-Transporter Measures in Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Clinical versus Experimental Measures of Impulsivity

Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders

The Roles of Norepinephrine and Serotonin in Attention Deficit Hyperactivity Disorder

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Binding of [<sup>3</sup>H]lysergic Acid Diethylamide to Serotonin 5-HT<sub>2A</sub> Receptors and of [<sup>3</sup>H]paroxetine to Serotonin Uptake Sites in Platelets from Healthy Children, Adolescents and Adults

Cited by 4 publications

References 22 publications

Serotonin Platelet-Transporter Measures in Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Clinical versus Experimental Measures of Impulsivity

Serotonin Platelet-Transporter Measures in Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Clinical versus Experimental Measures of Impulsivity

Platelet serotonin transporter and 5-HT2Areceptor binding in adolescents with eating disorders

The Roles of Norepinephrine and Serotonin in Attention Deficit Hyperactivity Disorder

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Platelet serotonin transporter and 5-HT_2Areceptor binding in adolescents with eating disorders