Binding of novel octahedral metal complexes to DNA

Photoinduced cleavage and DNA-binding of the Ruthenium(II) polypyridyl complex [Ru(phen)2(ipbd)](ClO4)2

“…However, the binding mode of the prototype complex [Ru(phen) 3 ] 2+ is still an issue of vigorous debate [16][17][18][19]. Many studies show that ruthenium(II) polypyridyl complexes can bind to DNA in a non-covalent interaction fashion such as electrostatic binding, groove binding, intercalative binding and partial intercalative binding [20][21][22]. In this paper, a novel ruthenium(II) polypyridyl complex [Ru(phen) 2 (ipbd)] 2+ [ipbd = 3-(1H-Imidazo [4,5-f] [1,10]phenanthrolin-2-yl)-1-benzodioxane, phen = 1,10-phenanthroline, Scheme 1] has been synthesized and characterized.…”

Effects of the substitution positions of Br group in intercalative ligand on the DNA-binding behaviors of Ru(II) polypyridyl complexes

“…The binding mode of the prototype complex [Ru(phen) 3 ] 2þ (phen ¼ 1,10-phenanthroline) is still an issue of vigorous debate [8][9][10][11]. Ru(II) polypyridyl complexes can bind to DNA in a non-covalent interactions fashion such as electrostatic binding, groove binding [12,13], intercalative binding and partial intercalative binding [14][15][16]. Many important applications of these complexes require that the complexes can bind to DNA in an intercalative mode.…”

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

“…Ruthenium(II) complexes with polypyridyl ligands, due to a combination of easily constructed rigid chiral structures spanning all three spatial dimensions and a rich photophysical repertoire, have attracted considerable attention [4][5][6][7][8][9]. Polypyridyl ruthenium(II) complexes can bind to DNA via non-covalent interactions such as electrostatic binding, groove binding [10,11], and intercalative binding which includes classical intercalation [12,13], semi-intercalation, and quasiintercalation [14]. Many ruthenium(II) complexes show interesting properties upon binding to DNA, such as [Ru(bpy) 2 (dppz)] 2?…”