Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy

Sun, Qiqi; Zhao, Quan; He, Ziyun; Tang, Lei; Pu, Yuji; He, Bin

doi:10.1016/j.ijpharm.2023.122962

Cited by 15 publications

(4 citation statements)

References 61 publications

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“…Wild-type mice supplemented with selenium under the same conditions survived normally. A number of studies have been conducted to show that overexpression of reactive oxygen species (ROS) leads to inflammatory bowel disease due to damage to the intestinal mucosal barrier ( Sun et al, 2023 ; Yao et al, 2023 ). The study by Huang et al showed that scavenging ROS toxicity, improving cellular antioxidant capacity and alleviating cellular ERS by increasing GPX1 expression could greatly rescue the cell death situation ( Tao et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohn’s disease

Zou,

Liang,

Zhang

et al. 2023

Front. Genet.

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Background: Endoplasmic reticulum stress (ERS) is an important pathophysiological mechanism in ulcerative colitis (UC) and Crohn’s disease (CD). ERS-related genes may be influenced by genetic factors and intestinal inflammation. However, the role of ERS as a trigger or potential etiological factor for UC and CD is unclear, as the expression of ERS-related genes in UC and CD may be the cause or subsequent changes in intestinal inflammation. Here, we used a three-step summary data-based Mendelian randomization (SMR) approach integrating multi-omics data to identify putative causal effects of ERS-related genes in UC and CD.Methods: Genome-wide association study (GWAS) summary data for UC (6,968 cases and 20,464 controls) and CD (5,956 cases and 14,927 controls) were extracted as outcome, and DNA methylation quantitative trait loci (mQTL, 1,980 participants) data and expression QTL data (eQTL, 31,684 participants) from the blood were obtained as exposure. The ERS-related genes were extracted from the GeneCards database, and then the GWAS summary data were integrated with the mQTL and eQTL data associated with ERS genes by SMR. Sensitivity analysis included two-sample MR analysis, power calculations, Bayesian co-localization analysis, and phenotype scanning were performed to evaluate the robustness of the results.Results: A total of 1,193 ERS-related genes were obtained. The three-step SMR analysis showed that cg24011261 CpG site regulating GPX1 expression was associated with a low risk of UC, whereas GPX1 expression regulated by a combination of cg05055782, cg24011261, and cg05551922 CpG sites was associated with a low risk of CD. Sensitivity analysis further supports these findings.Conclusion: This multi-omics integration study identifies a causal relationship between the role of ERS in UC and CD and suggests potential new therapeutic targets for clinical practice.

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Section: Discussionmentioning

confidence: 99%

Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohn’s disease

Zou,

Liang,

Zhang

et al. 2023

Front. Genet.

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“…MPO is mainly secreted by activated neutrophils and is a viable clinical biomarker for evaluating disease severity. 40,41 The significant increase in MPO activity indicated active colitis of the mice in the DSS group (Fig. S9C †).…”

Section: Biomaterials Science Papermentioning

confidence: 97%

Engineered baicalein-decorated zinc phosphates for synergistic alleviation of inflammatory bowel disease by repairing the mucosal barrier and relieving oxidative stress

Liu,

Wu,

et al. 2023

Biomater. Sci.

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“…52 The concentration of reactive oxygen species (ROS) in the area of inflammation was found to be 10–100 times higher, providing a target and anchor for nanoparticles. 53–56 ROS-responsive moieties have been taken advantage of in the preparation of ROS-responsive prodrugs, such as the typical arylboronates, thiazolidinone, and selenium- or sulfur-containing classes. 57 Such nanocarriers can degrade selectively at the inflamed site with higher levels of ROS and release TNF-α siRNA with a strong siRNA gene silencing activity.…”

Section: Therapeutic Targeting Strategymentioning

confidence: 99%

Bioinspired and biomimetic strategies for inflammatory bowel disease therapy

Zhang,

Ye,

Zhu

et al. 2024

J. Mater. Chem. B

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Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy

Cited by 15 publications

References 61 publications

Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohn’s disease

Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohn’s disease

Engineered baicalein-decorated zinc phosphates for synergistic alleviation of inflammatory bowel disease by repairing the mucosal barrier and relieving oxidative stress

Bioinspired and biomimetic strategies for inflammatory bowel disease therapy

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