Bacteria-infected wound healing is a complex and chronic process that poses a great threat to human health. Thermosensitive hydrogel that undergoes a sol-gel transition at body temperature is an attractive...

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Wound dressing with good biocompatibility and bioactivity is urgently needed in wound treatment. Herein, we present a biocompatible hydrogel based on a natural polymer, konjac glucomannan (KGM), and explore its...

Biodegradable polymers are important in medical applications including absorbable medical devices and drug delivery systems. Copolymerization is an effective approach to extent the diversity of biodegradable polymers with combined certain properties of each components. In order to receive biodegradable polymers possess both advantages of poly(L-lactide) and poly(p-dioxanone), a series of biodegradable poly(L-lactide-co-p-dioxanone) (P(LLA-co-PDO)) copolymers with random and block architectures were synthesized via one-step or two-step ring-opening polymerizations of L-lactide (LLA) and p-dioxanone (PDO) monomers in the presence of stannous octoate [Sn(Oct) 2 ]. The compositions of PDO in random copolymers were much lower than those in feeding doses, implying low reactivity of PDO in the copolymerization. The molecular weights of PPDO segments and the ratios between PPDO and LLA were the key factors to affect the compositions of PLLA-PPDO-PLLA triblock copolymers in two-step polymerization. The thermal, mechanical and degradation properties of the copolymers were investigated. The amorphous and semicrystalline P(LLA-co-PDO) copolymers are potentially utilized in biomedical applications.

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