Bio‐based succinic acid: an overview of strain development, substrate utilization, and downstream purification

Abstract

Succinic acid is an industrially important platform chemical that could be used as precursor for the establishment of a sustainable chemical industry. Due to the depletion of crude oil and the need for sustainable development, the biological production of succinic acid from renewable resources has attracted wide attention. To establish an economical bio‐based succinic acid production process, various metabolic engineering strategies have been developed and applied to improve the strain performance, including efficient CO2 fixation, by‐product elimination, use of metabolic modeling approaches, engineering of transcriptional regulations and optimization of reducing power balance. The utilization of renewable waste resources and the optimization of purification process have also been investigated to decrease the cost. This review will provide insights for current advances in succinic acid production and perspectives on further research to make bio‐based succinic acid production more efficient and economical. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd

Revitalizing the sugarcane industry by adding value to A‐molasses in biorefineries

“…21 The potential for SA as a platform chemical to replace maleic anhydride for the production of bio-based 1,4-butanediol 22 is the main driver for the growing global SA market, estimated at 40 kt/year in 2011 and expected to grow to 600 kt/year by 2020. 23,24 On the other hand, the global production output shortchain fructooligosaccharides (scFOS) reported in 2015 was 134 kt/year and projected to almost double by 2024 25 due to the rising demand for scFOS as functional foods and their properties as prebiotics and low-calorie sweeteners with health benefits. 26 These health benefits include prevention of colon cancer, reduction of cholesterol levels in the body (thus, preventing obesity and is safe for diabetic patients) and improved mineral absorption in the gut.…”

Valorisation of xylose to renewable fuels and chemicals, an essential step in augmenting the commercial viability of lignocellulosic biorefineries

“…Like LA, SA is a platform chemical and due to the presence of two carboxyl acid groups, SA can be converted into a variety of products such as succinic anhydride, succinic esters, 2-pyrrolidine, and polyesters for synthesizing biodegradable plastics. 131 According to global market research, the market size was expected to reach $237.8 million by 2022 with a CAGR of 9.2% (Succinic Acid Market Size & Share | Industry Analysis Report, 2022 ( )). SA production from pure sugars and LCB hydrolysates has been reported using natural producers Anaerobiospirillum succiniciproducens , Actinobacillus succinogenes , Mannheimia succiniciproducens , Basfia succiniciproducens and genetically engineered strains E. coli and Y. lipolytica ( Table 4 ).…”

Utilization of Agricultural Waste Biomass And Recycling Towards Circular Bioeconomy

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