Bio-inspired physical layered device architectures for diffusion-based molecular communication: Design Issues and suggestions

Chude-Okonkwo, Uche A. K.; Malekian, Reza; Mharaj, B T; Olisah, Chollette C.

doi:10.1109/indin.2015.7281950

Cited by 5 publications

(4 citation statements)

References 76 publications

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“…28 The targeted nanonetwork-based MolCom system consists of N number of nanomachines labeled by FRET technology; they are named as transmitter nanomachine (nanotransmitter), relay nanomachine (nanorelay), and receiver nanomachine (nanoreceiver) as demonstrated in Figure 3. 28 The targeted nanonetwork-based MolCom system consists of N number of nanomachines labeled by FRET technology; they are named as transmitter nanomachine (nanotransmitter), relay nanomachine (nanorelay), and receiver nanomachine (nanoreceiver) as demonstrated in Figure 3.…”

Section: System Modelmentioning

confidence: 99%

“…We consider the IoBNT paradigm comprises downlink/uplink-based biocyber interface, and targeted nanonetworkbased MolCom system while the communication channel is represented by blood vessel. 28 The targeted nanonetwork-based MolCom system consists of N number of nanomachines labeled by FRET technology; they are named as transmitter nanomachine (nanotransmitter), relay nanomachine (nanorelay), and receiver nanomachine (nanoreceiver) as demonstrated in Figure 3. The design's architecture of the mentioned nanomachines is inspired by living cells and organs of the biological system.…”

Section: System Modelmentioning

confidence: 99%

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MolCom system with downlink/uplink biocyber interface for Internet of Bio‐NanoThings

El-atty

Bidar

El-Rabaie

2019

Int J Communication

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Inspired by wireless communication systems, we propose a feasible downlink/uplink biocyber interface for the expected targeted drug delivery system based on Internet of Biological NanoThing (IoBNT) paradigm. The downlink/uplink biocyber interface of IoBNT comprises Fluorescence Resonance Energy Transfer (FRET) and Molecular Communication (MolCom) technology. On the downlink (from Internet to targeted nanonetwork), the biocyber interface transduces electromagnetic (EM) signal to biochemical signals, and thus with the help of mobile MolCom system based on FRET nanocommunication, the drug information delivers to the diseased cell within the targeted intrabody nanonetwork. On the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical signal to EM signal. As a result, the paradigm of IoBNT responses by proper functions to these changes according to the decision of medical health care. The performance analysis of the proposed IoBNT system is numerically investigated through MolCom system-based FRET, while the performance evaluation is evaluated by employing spreading epidemic scheme in terms of success-ful probability of drug delivery, channel capacity, average drug-delivery time, and throughput. The simulation results show that the proposed IoBNT is a promising paradigm for smart drug delivery system, and its performance is mainly based on the nanostructure and the characteristic of molecular nanomachines in the targeted nanonetwork.

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Section: System Modelmentioning

confidence: 99%

Section: System Modelmentioning

confidence: 99%

MolCom system with downlink/uplink biocyber interface for Internet of Bio‐NanoThings

El-atty

Bidar

El-Rabaie

2019

Int J Communication

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“…The nTR 2 and nTR 3 can be achieved by the use of genetically engineered biological cells [22], a genetically engineered bacterium [23] and artificial cells [24]. In [25,26] model examples of a genetically engineered biotransceiver that can be used to model the molecule synthesis and emission in nTR 2 and nTR3 are presented. The systems biology related model for the execution of self-annihilation in the nanodevices is presented in [15].…”

Section: System Modelmentioning

confidence: 99%

Biologically Inspired Bio-Cyber Interface Architecture and Model for Internet of Bio-NanoThings Applications

Chude-Okonkwo

Malekian

Maharaj

2016

IEEE Trans. Commun.

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“…The molecular antennas of interest within the scope addressed in this work are the surface enzymes and surface receptors. Such model can find application in scenarios that are related to the activation of prodrugs by enzymes at targeted drug delivery sites [51] and any reception mechanism that mimics the ligand-receptor binding mechanisms such as those presented in [34,92,93]. However, for absorbing receivers [94], which in relation to cellular activities mimic information transfer through membrane diffusion and endocytosis/exocytosis processes, the model has to be modified to account for information molecules detection and removal from the propagation environment.…”

Section: Frequency Analysis Of the Propagation Modelsmentioning

confidence: 99%

Diffusion-controlled interface kinetics-inclusive system-theoretic propagation models for molecular communication systems

Chude-Okonkwo

Malekian

Maharaj

2015

EURASIP J. Adv. Signal Process.

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Inspired by biological systems, molecular communication has been proposed as a new communication paradigm that uses biochemical signals to transfer information from one nano device to another over a short distance. The biochemical nature of the information transfer process implies that for molecular communication purposes, the development of molecular channel models should take into consideration diffusion phenomenon as well as the physical/biochemical kinetic possibilities of the process. The physical and biochemical kinetics arise at the interfaces between the diffusion channel and the transmitter/receiver units. These interfaces are herein termed molecular antennas. In this paper, we present the deterministic propagation model of the molecular communication between an immobilized nanotransmitter and nanoreceiver, where the emission and reception kinetics are taken into consideration. Specifically, we derived closed-form system-theoretic models and expressions for configurations that represent different communication systems based on the type of molecular antennas used. The antennas considered are the nanopores at the transmitter and the surface receptor proteins/enzymes at the receiver. The developed models are simulated to show the influence of parameters such as the receiver radius, surface receptor protein/enzyme concentration, and various reaction rate constants. Results show that the effective receiver surface area and the rate constants are important to the system's output performance. Assuming high rate of catalysis, the analysis of the frequency behavior of the developed propagation channels in the form of transfer functions shows significant difference introduce by the inclusion of the molecular antennas into the diffusion-only model. It is also shown that for t > > 0 and with the information molecules' concentration greater than the Michaelis-Menten kinetic constant of the systems, the inclusion of surface receptors proteins and enzymes in the models makes the system act like a band-stop filter over an infinite frequency range.

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Bio-inspired physical layered device architectures for diffusion-based molecular communication: Design Issues and suggestions

Cited by 5 publications

References 76 publications

MolCom system with downlink/uplink biocyber interface for Internet of Bio‐NanoThings

MolCom system with downlink/uplink biocyber interface for Internet of Bio‐NanoThings

Biologically Inspired Bio-Cyber Interface Architecture and Model for Internet of Bio-NanoThings Applications

Diffusion-controlled interface kinetics-inclusive system-theoretic propagation models for molecular communication systems

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