Inspired by wireless communication systems, we propose a feasible downlink/uplink biocyber interface for the expected targeted drug delivery system based on Internet of Biological NanoThing (IoBNT) paradigm. The downlink/uplink biocyber interface of IoBNT comprises Fluorescence Resonance Energy Transfer (FRET) and Molecular Communication (MolCom) technology. On the downlink (from Internet to targeted nanonetwork), the biocyber interface transduces electromagnetic (EM) signal to biochemical signals, and thus with the help of mobile MolCom system based on FRET nanocommunication, the drug information delivers to the diseased cell within the targeted intrabody nanonetwork. On the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical signal to EM signal. As a result, the paradigm of IoBNT responses by proper functions to these changes according to the decision of medical health care. The performance analysis of the proposed IoBNT system is numerically investigated through MolCom system-based FRET, while the performance evaluation is evaluated by employing spreading epidemic scheme in terms of success-ful probability of drug delivery, channel capacity, average drug-delivery time, and throughput. The simulation results show that the proposed IoBNT is a promising paradigm for smart drug delivery system, and its performance is mainly based on the nanostructure and the characteristic of molecular nanomachines in the targeted nanonetwork.

We propose an embedded synthetic relay transport protein (RTP) approach for communication between the external environment (blood vessels) and internal targeted nanonetworks (cells/tissues) within the intra-body network. In fact, we designed a bioengineered relay protein-based facilitated diffusing to be an alternative protein in the case of biological transport proteins (such as protein channels, e.g. Pores) failing. The proposed approach is inspired by the traditional wireless communication system-based relay concept, in which embedded nanodevices known as donor, relay, and acceptor bionanomachine construct a molecular communication system. Fluorescence resonance energy transfer nanocommunications are used to connect the embedded bionanomachines, and the therapeutic drug is transferred in the form of exciton. The performance analysis of the proposed approach is evaluated in terms of channel capacity of RTP as function of intrinsic environmental parameters and the location of the relay between the donor, and acceptor bionanomachines. The numerical results show that the proposed approach improves channel capacity by 16.7% over previous work.