Bio‐Micromotor Tweezers for Noninvasive Bio‐Cargo Delivery and Precise Therapy (Adv. Funct. Mater. 16/2022)

Pan, Ting; Shi, Yang; Zhao, Nan; Xiong, Jianyun; Xiao, Yilin; Xin, Hongbao; Li, Baojun

doi:10.1002/adfm.202270097

Cited by 9 publications

(11 citation statements)

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“…Targeted drug/gene delivery is of great significance for precise cell regulation and therapy. [ 20 ] The photothermal damage‐free feature of CMF strategy serves as excellent candidate for collective gene/drug delivery. HL‐60 cells stably expressing green fluorescent protein (GFP) are subjected to Cy3‐labeled RNA mimics (GFP‐siRNA, see the Experimental Section) formulations for gene knockdown experiments.…”

Section: Resultsmentioning

confidence: 99%

Light‐Induced Cold Marangoni Flow for Microswarm Actuation: From Intelligent Behaviors to Collective Drug Delivery

Shi

Wang

Xiao

et al. 2022

Laser & Photonics Reviews

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Microswarms have shown great potential in biomedical applications at small scales due to their features of wireless actuation and collective microrobotic behaviors. However, actuation of microswarms with strong universality and intelligent biomimetic behaviors is always a great challenge. Here, photothermal damage-free actuation of an intelligent microswarm based on light-induced cold Marangoni flow (CMF) is reported, along with collective drug delivery and targeted cell chemotherapy. This microswarm actuation shows strong universality and high controllability for both abiotic particles and living materials. Importantly, this microswarm exhibits intelligent biomimetic behaviors, such as collective migration, size-based self-organization, and group rejection, due to the synergy between cold flow with individual agents. The distinctive photothermal isolation capability of CMF ensures the microswarm to perform photothermal damage-free biomedical tasks such as collective gene delivery and targeted single-cell chemotherapy. This light-induced CMF provides an optical strategy for photothermal damage-free actuation of intelligent biomimetic microswarm robots, with great promises to perform many collective and cognitive tasks in biomedical applications such as cooperative grasping, collective drug delivery, and precise chemotherapy. IntroductionIn the biological world, many individual organisms, such as honeybees, ants, and herrings, can gather together to form swarms, resulting in hierarchical organizational frameworks. [1] Although individual behaviors are governed by relatively simple rules, the communication and interaction of a vast number of individuals allows swarms to be constructed and assembled into various forms. These swarms exhibit complicated collective behaviors and functions, drastically altering how they interact with their surroundings. [2] Similarly, research on artificial microswarms opens many new possibilities for exploring dynamic interactions

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Section: Resultsmentioning

confidence: 99%

Light‐Induced Cold Marangoni Flow for Microswarm Actuation: From Intelligent Behaviors to Collective Drug Delivery

Shi

Wang

Xiao

et al. 2022

Laser & Photonics Reviews

Self Cite

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“…By regulating the parameters of the external rotating magnetic field, the locomotion of hematite microrobots possesses the feature of flexible and remote control. Moreover, the rotation of the peculiar dendrite‐like structure impels the adjacent fluid to produce a local hydrodynamic flow field to manipulate targeted cells without contact [48] . Yeast cells were selected as a cell model.…”

Section: Resultsmentioning

confidence: 99%

Self‐Propelled Magnetic Dendrite‐Shaped Microrobots for Photodynamic Prostate Cancer Therapy

et al. 2022

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Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down‐regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite‐shaped light‐powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non‐contact transportation of micro‐sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite‐shaped hematite microrobots contribute to developing dual light/magnetic field‐powered micromachines for the biomedical field.

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“…Furthermore, tweezer‐specific concerns are found in the combined inherent heating of a focused beam and materials trapped in the optical beam. In response, photo‐activated Marangoni‐driven machines or combinations of optical tweezers and other stimuli have been studied [66, 67] …”

Section: Mnm Mobility Modesmentioning

confidence: 99%

Achieving Control in Micro‐/Nanomotor Mobility

Fusi

Llopis‐Lorente

et al. 2022

Angewandte Chemie

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Unprecedented opportunities exist for the generation of advanced nanotechnologies based on synthetic micro/ nanomotors (MNMs), such as active transport of medical agents or the removal of pollutants. In this regard, great efforts have been dedicated toward controlling MNM motion (e.g., speed, directionality). This was generally performed by precise engineering and optimizing of the motors' chassis, engine, powering mode (i.e., chemical or physical), and mechanism of motion. Recently, new insights have emerged to control motors mobility, mainly by the inclusion of different modes that drive propulsion. With high degree of synchronization, these modes work providing the required level of control. In this Minireview, we discuss the diverse factors that impact motion; these include MNM morphology, modes of mobility, and how control over motion was achieved. Moreover, we highlight the main limitations that need to be overcome so that such motion control can be translated into real applications.

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Bio‐Micromotor Tweezers for Noninvasive Bio‐Cargo Delivery and Precise Therapy (Adv. Funct. Mater. 16/2022)

Cited by 9 publications

References 0 publications

Light‐Induced Cold Marangoni Flow for Microswarm Actuation: From Intelligent Behaviors to Collective Drug Delivery

Light‐Induced Cold Marangoni Flow for Microswarm Actuation: From Intelligent Behaviors to Collective Drug Delivery

Self‐Propelled Magnetic Dendrite‐Shaped Microrobots for Photodynamic Prostate Cancer Therapy

Achieving Control in Micro‐/Nanomotor Mobility

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