Bioaccumulation and behavioural effects of depleted uranium in rats exposed to repeated inhalations

Monleau, Marjorie; Bussy, Cyrill; Lestaevel, Philippe; Houpert, P.; Paquet, F.; Chazel, V.

doi:10.1016/j.neulet.2005.07.051

Cited by 66 publications

(39 citation statements)

References 30 publications

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“…hyperactivity, has been described in adult rats exposed to U. Locomotor activity and rearing movements increased by 100% in an open field over a 5-min observation period in adult rats exposed to 150 mg U.L -1 for either 2 weeks or 6 months (Briner and Murray, 2005). Similarly, a 25% increase in locomotor activity and a 35% increase in rearing movements have been reported over a 5-15 min observation period in an open field in rats exposed to repeated U inhalation (30 min inhalation at 197 mg.m -3 , 4 days a week for 3 weeks) (Monleau et al, 2005). These differences in motor activity were unexpected.…”

Section: Discussionmentioning

confidence: 75%

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

et al. 2015

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-In view of the known sensitivity of the developing central nervous system to pollutants, we sought to assess the effects of exposure to uranium (U) -a heavy metal naturally present in the environment -on the behavior of young rats and the impact of oxidative stress on their hippocampus. Pups drank U (in the form of uranyl nitrate) at doses of 10 or 40 mg.L -1 for 10 weeks from birth. Control rats drank mineral water. Locomotor activity in an open field and practice effects on a rotarod device decreased in rats exposed to 10 mg.L -1 (respectively, -19.4% and -51.4%) or 40 mg.L -1 (respectively, -19.3% and -55.9%) in compared with control rats. Anxiety (+37%) and depressive-like behavior (-50.8%) were altered by U exposure only at 40 mg.L -1 . Lipid peroxidation (+35%) and protein carbonyl concentration (+137%) increased significantly after exposure to U at 40 mg.L -1 . A significant increase in superoxide dismutase (SOD, +122.5%) and glutathione peroxidase (GPx, +13.6%) activities was also observed in the hippocampus of rats exposed to 40 mg.L -1 . These results demonstrate that exposure to U since birth alters some behaviors and modifies antioxidant status.

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Section: Discussionmentioning

confidence: 75%

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

et al. 2015

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“…In this case, after uranium crosses the blood-brain barrier behavioral changes and lipid oxidation were observed in rats, in as little as 2 weeks. In agreement Monleau et al (2005) proved that after repeated exposure to uranium dioxide particles by inhalation, uranium bioaccumulates in the brain producing behavioral changes (Monleau et al, 2005). A possible mechanism of this neurotoxicity could be the oxidative stress induced by reactive oxygen species imbalance.…”

Section: The Nervous Systemmentioning

confidence: 76%

Intracellular Metabolism of Uranium and the Effects of Bisphosphonates on Its Toxicity

Tasat¹,

Orona²,

Bozal³

et al. 2012

Cell Metabolism - Cell Homeostasis and Stress Response

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“…Spatial working the rats exposed to U since birth and the control group. However, working memory can be decreased in rats that undergo chronic U exposure in adulthood at a high dose (40 mg/kg/day), or acute exposure (1 mg/kg in IM injection) or exposure by inhalation (Albina et al, 2005;Monleau et al, 2005;Barber et al, 2007). All these results indicate that exposure to U during development or adulthood can induce different behavioral effects.…”

Section: Discussionmentioning

confidence: 95%

Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium

et al. 2013

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-The central nervous system (CNS) is known to be sensitive to pollutants during its development. Uranium (U) is a heavy metal that occurs naturally in the environment as a component of the earth's crust, and populations may therefore be chronically exposed to U through drinking water and food. Previous studies have shown that the CNS is a target of U in rats exposed in adulthood. We assessed the effects of U on behavior and cholinergic system of rats exposed from birth for 10 weeks at 10 mg.L -1 or 40 mg.L -1 . For behavioral analysis, the sleep/wake cycle (recorded by telemetry), the object recognition memory and the spatial working memory (Y-maze) were evaluated. Acetylcholine (ACh) and acetylcholinesterase (AChE) levels were evaluated in the entorhinal cortex and hippocampus. At 40 mg.L -1 , U exposure impaired object recognition memory (-20%), but neither spatial working memory nor the sleep/wake and cholinergic system was observed at 10 mg U.L -1 . These results demonstrate that early exposure to U -ory process in rats. This exposure to U early in life could have potential delayed effects in adulthood.

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Bioaccumulation and behavioural effects of depleted uranium in rats exposed to repeated inhalations

Cited by 66 publications

References 30 publications

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

Intracellular Metabolism of Uranium and the Effects of Bisphosphonates on Its Toxicity

Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium

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