Bioaccumulation and depuration of TiO2 nanoparticles by zebrafish through dietary exposure: Size- and number concentration-resolved analysis using single-particle ICP-MS

Lu, Hsin-Yi; Wang, Ying Jan; Hou, Wen Che

doi:10.1016/j.jhazmat.2021.127801

Cited by 13 publications

(15 citation statements)

References 44 publications

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“…9 As a comparison, recent work has shown α = 0.18 ± 0.07 for dietary TiO 2 NP exposure to zebrafish. 22 α for AgNP trophic transfer to marine medaka was reported to be ∼0.06. 21 The reason that the dietary AgNP and Ag + exposure routes show similar α and BMF k (Table 2) is speculated to be the dynamic fate of AgNPs and Ag + in fish discussed earlier.…”

Section: Discussionmentioning

confidence: 99%

“…The BMF k values of ∼0.01 for both treatments (Table 2) were ∼2 orders of magnitude smaller than the threshold BMF of unity, consistent with the results of recent studies about AgNPs bioaccumulating in marine medaka (BMF of ∼0.01) and TiO 2 NPs in zebrafish (BMF < 0.024). 21,22,35…”

Section: Discussionmentioning

confidence: 99%

“…The design of this study was similar to that in our prior work which generally followed the OECD TG305. 9,22 Wild-type (WT) AB strain zebrafish ( Danio rerio ) obtained from the Taiwan Zebrafish Core Facility at Academia Sinica (TZCAS) were kept in the Zebrafish Core Facility (ZCF) of the Laboratory Animal Center at National Cheng Kung University (NCKU). All animal procedures were performed in accordance with the Guidelines for Care and Use of Laboratory Animals of NCKU and approved by the Institutional Animal Care and Use Committee (IACUC) of NCKU.…”

Section: Methodsmentioning

confidence: 99%

“…, minimal dissolution or aggregation or particulate Ag formation in the case of Ag + ) prior to spICP-MS analysis. We performed some tests about the optimal digestion temperature (35 vs. 50 °C) and duration (1–3 h) following the method reported in our previous work using enzyme proteinase K. 22 The procedure is detailed in the ESI †. We found (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…19 Hence, recent research begins to explore the kinetic approach for the bioaccumulation of ENMs. 13,20–22 The kinetic approach considers the organism as a single compartment whose internal test chemical concentrations ( i.e. , the body burden) are controlled by the rate of chemical uptake from the surrounding media ( e.g.…”

Section: Introductionmentioning

confidence: 99%

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Uptake and depuration of Ag nanoparticles versus Ag ions by zebrafish through dietary exposure: characterization of Ag nanoparticle formation and dissolution in vivo and toxicokinetic modeling

Yang

Hou

2022

Environ. Sci.: Nano

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Uptake and depuration of Ag nanoparticles versus Ag ions by zebrafish through dietary exposure: characterization of Ag nanoparticle formation and dissolution in vivo and toxicokinetic modeling

Yang

Hou

2022

Environ. Sci.: Nano

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Assessing comparable bioconcentration potentials for nanoparticles in aquatic organisms via combined utilization of machine learning and toxicokinetic models

Dong

Wang

et al. 2022

SmartMat

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The toxicokinetic (TK) model‐derived kinetic bioconcentration factor (BCFk) provides a quantitatively comparable index to estimate the bioaccumulation potential of nanoparticles (NPs) that barely reach thermodynamic equilibrium in aquatic organisms, but experimental data are limited for various NPs. In the present study, a machine learning model was applied to offer reliable in silico predictions for the dynamic body burden of diverse NPs to derive corresponding parameters for the TK model. The developed eXtreme Gradient Boosting‐derived TK (XGB‐TK) model was applied to predict BCFk results for a broad range of metallic or carbonaceous NPs, with an appreciable prediction R2 of 0.96. The BCFk values were predicted based on a random combination of selected variable features, revealing that their bioaccumulation potential showed an overall negative correlation with NP density or organism size. By applying importance analysis and partial dependence plots, NP density and organism size were revealed to be the top essential features that impact the bioaccumulation potential. The conjunctively used XGB‐TK model enabled a prior comparison for diverse NPs and straightforward derivation on the dependency of features, which could also guide the bioaccumulation mechanism exploration and experimental condition formulation.

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Critical evaluation of the potential of ICP-MS-based systems in toxicological studies of metallic nanoparticles

Fernández-Trujillo,

Jiménez-Moreno,

Rodríguez-Fariñas

et al. 2024

Anal Bioanal Chem

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The extensive application of metallic nanoparticles (NPs) in several fields has significantly impacted our daily lives. Nonetheless, uncertainties persist regarding the toxicity and potential risks associated with the vast number of NPs entering the environment and human bodies, so the performance of toxicological studies are highly demanded. While traditional assays focus primarily on the effects, the comprehension of the underlying processes requires innovative analytical approaches that can detect, characterize, and quantify NPs in complex biological matrices. Among the available alternatives to achieve this information, mass spectrometry, and more concretely, inductively coupled plasma mass spectrometry (ICP-MS), has emerged as an appealing option. This work critically reviews the valuable contribution of ICP-MS-based techniques to investigate NP toxicity and their transformations during in vitro and in vivo toxicological assays. Various ICP-MS modalities, such as total elemental analysis, single particle or single-cell modes, and coupling with separation techniques, as well as the potential of laser ablation as a spatially resolved sample introduction approach, are explored and discussed. Moreover, this review addresses limitations, novel trends, and perspectives in the field of nanotoxicology, particularly concerning NP internalization and pathways. These processes encompass cellular uptake and quantification, localization, translocation to other cell compartments, and biological transformations. By leveraging the capabilities of ICP-MS, researchers can gain deeper insights into the behaviour and effects of NPs, which can pave the way for safer and more responsible use of these materials. Graphical abstract

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Bioaccumulation and depuration of TiO2 nanoparticles by zebrafish through dietary exposure: Size- and number concentration-resolved analysis using single-particle ICP-MS

Cited by 13 publications

References 44 publications

Uptake and depuration of Ag nanoparticles versus Ag ions by zebrafish through dietary exposure: characterization of Ag nanoparticle formation and dissolution in vivo and toxicokinetic modeling

Uptake and depuration of Ag nanoparticles versus Ag ions by zebrafish through dietary exposure: characterization of Ag nanoparticle formation and dissolution in vivo and toxicokinetic modeling

Assessing comparable bioconcentration potentials for nanoparticles in aquatic organisms via combined utilization of machine learning and toxicokinetic models

Critical evaluation of the potential of ICP-MS-based systems in toxicological studies of metallic nanoparticles

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