Bioactive azaphilones from the fungus Penicillium multicolor CM01

Hemtasin, Chulida; Kanokmedhakul, Somdej; Moosophon, Panawan; Soytong, Kasem; Kanokmedhakul, Kwanjai

doi:10.1016/j.phytol.2016.03.004

Cited by 28 publications

(18 citation statements)

References 27 publications

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“…Extrolites : All species examined in ser. Sclerotiorum produce sclerotiorins, rotiorin, penazaphilones, penicilazaphilones ( Curtin and Reilly, 1940 , Maccurin and Reilly, 1940 , Birkinshaw, 1952 , Jackman et al., 1958 , Arai et al., 1995 , Matsuzaki et al., 1995a , Matsuzaki et al., 1995b , Pairet et al., 1995 , Nam et al., 2000 , Lucas et al., 2007 , Arunpanichlert et al., 2010 , Hemtasin et al., 2016 , Zhou et al., 2016 , Wang et al., 2018 , Jia et al., 2019 , Tang et al., 2019a , Wu et al., 2019 ), penicilisorin, (+)-4,6-dimetylocta-2,4-dienoic acid and 5,6-dihydro-3,5,6-trimethylpyran-2-one ( Arunpanichlert et al. 2010 ), pencolide ( Birkinshaw et al., 1963 , Lucas et al., 2007 ), carotenes ( Mase et al.…”

Section: Resultsmentioning

confidence: 99%

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Houbraken¹,

Kocsubé²,

Visagie³

et al. 2020

Studies in Mycology

404

458

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The Eurotiales is a relatively large order of Ascomycetes with members frequently having positive and negative impact on human activities. Species within this order gain attention from various research fields such as food, indoor and medical mycology and biotechnology. In this article we give an overview of families and genera present in the Eurotiales and introduce an updated subgeneric, sectional and series classification for Aspergillus and Penicillium . Finally, a comprehensive list of accepted species in the Eurotiales is given. The classification of the Eurotiales at family and genus level is traditionally based on phenotypic characters, and this classification has since been challenged using sequence-based approaches. Here, we re-evaluated the relationships between families and genera of the Eurotiales using a nine-gene sequence dataset. Based on this analysis, the new family Penicillaginaceae is introduced and four known families are accepted: Aspergillaceae , Elaphomycetaceae , Thermoascaceae and Trichocomaceae . The Eurotiales includes 28 genera: 15 genera are accommodated in the Aspergillaceae ( Aspergillago , Aspergillus , Evansstolkia , Hamigera , Leiothecium , Monascus , Penicilliopsis , Penicillium , Phialomyces , Pseudohamigera , Pseudopenicillium , Sclerocleista , Warcupiella , Xerochrysium and Xeromyces ), eight in the Trichocomaceae ( Acidotalaromyces , Ascospirella , Dendrosphaera , Rasamsonia , Sagenomella , Talaromyces , Thermomyces , Trichocoma ), two in the Thermoascaceae ( Paecilomyces , Thermoascus ) and one in the Penicillaginaceae ( Penicillago ). The classification of the Elaphomycetaceae was not part of this study, but according to literature two genera are present in this family ( Elaphomyces and Pseudotulostoma ). The use of an infrageneric classification system has a long tradition in Aspergillus and Penicillium . Most recent taxonomic studies focused on the sectional l...

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Section: Resultsmentioning

confidence: 99%

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Houbraken¹,

Kocsubé²,

Visagie³

et al. 2020

Studies in Mycology

404

458

View full text Add to dashboard Cite

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“…This is a Monascus -like pigment with the replacement of C-6 hydrogen with chlorine. Production of sclerotiorin as well as its derivates by other Penicillium species is also reported (Hemtasin et al, 2016). Those Penicillium species do not co-produce citrinin or any other known mycotoxins and non-pathogenic to humans, which are potential strains for production of food pigments (Mapari et al, 2008; Dufossé et al, 2014; Gomes and Takahashi, 2016).…”

Section: Production Of Monascus-like Pigmentsmentioning

confidence: 94%

Diversifying of Chemical Structure of Native Monascus Pigments

Liu

Zhao²,

Huang

et al. 2018

Front. Microbiol.

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Red Yeast Rice, produced by solid state fermentation of Monascus species on rice, is a traditional food additive and traditional Chinese medicine. With the introduction of modern microbiology and biotechnology to the traditional edible filamentous fungi Monascus species, it has been revealed that the production of red colorant by fermentation of Monascus species involves the biosynthesis of orange Monascus pigments and further chemical modification of orange Monascus pigments into the corresponding derivates with various amine residues. Further study indicates that non-Monascus species also produce Monascus pigments as well as Monascus-like pigments. Based on the chemical modification of orange Monascus pigments, the diversification of native Monascus pigments, including commercial food additives of Red Monascus Pigments® and Yellow Monascus Pigments® in Chinese market, was reviewed. Furthermore, Monascus pigments as well as their derivates as enzyme inhibitors for anti-obesity, hyperlipidemia, and hyperglycemia was also summarized.

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“…BS4 37 Antimicrobial (Staphylococcus aureus: 5.0 mg mL À1 ) Colletotrichone C (56) Colletotrichum sp. BS4 37 Antimicrobial (Escherichia coli: 5.0 mg mL À1 ) Coniellin A (57) Coniella fragariae 9 Anti-tumor (MDA-MB-231: 21.5 mM, inhibit NF-kB activation: 4.4 mM) Coniellin B (58) Coniella fragariae 9 Anti-tumor (MDA-MB-231: 19.6 mM) Coniellin C (59) Coniella fragariae 9 Anti-tumor (MDA-MB-231: 21.0 mM) Coniellin D (60) Coniella fragariae 9 Anti-tumor (MDA-MB-231: 18.6 mM, inhibit NF-kB activation: 37.8 mM) Coniellin E (61) Coniella fragariae 9 Anti-tumor (MDA-MB-231: 79.3 mM, inhibit NF-kB activation: 29.4 mM) Coniellin F (62) Coniella fragariae 9 Anti-tumor (inhibit NF-kB activation: 70.7 mM) Coniellin G (63) Coniella fragariae 9 Anti-tumor (MDA-MB-231: 21.6 mM, inhibit NF-kB activation: 11.3 mM) Coniellins H-I (64)(65) Coniella fragariae 35 5 0 ,6 0 -Dihydroxyacetosellin (66) Epicoccum nigrum strain 749 38 Monakaocinol 67Monascus kaoliang 39 Monascuspirolide A (68) Monascus purpureus BCRC 38110 42 Anti-inammatory (inhibit NO production: 17.5 mM) Monascuspirolide B (69) Monascus purpureus BCRC 38110 42 Anti-inammatory (inhibit NO production: 23.5 mM) Thielavialides A-E (70)(71)(72)(73)(74) Thielavia sp. PA0001 40…”

Section: Species Activitymentioning

confidence: 99%

“…Signicantly, 157 showed AChE inhibitory activity with a minimum inhibition requirement of 0.03 nM, while 158 exhibited notable antimalarial activity and cytotoxicity. 70 The mangrove endophytic fungus Penicillium sp. 303, produced a novel azaphilone 159, which exhibited weak cytotoxicity toward a series of human cancer lines.…”

Section: Sclerotiorin-like Azaphilonesmentioning

confidence: 99%