Bioactive bacterial cellulose wound dressings for burns with collagen in-situ and chitosan ex-situ impregnation

Pasaribu, Khatarina Meldawati; Tamrin, Tamrin; Swingler, Sam; Gupta, Abhishek; Stamboulis, Artemis; Gea, Saharman

doi:10.1016/j.ijbiomac.2022.123118

Cited by 47 publications

(30 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The XRD characteristic diffraction peaks of PCL were found to be at 21.4° and 23.7°, and the characteristic peaks of PEO were located at 19.3° and 23.6°, based on the literature [ 43 ]. The characteristic diffraction peaks of chitosan were at 8.6°, 11.8°, 18.5°, and 23.1° [ 44 , 45 ]. The resulting PCL/PEO samples showed three characteristic peaks at 19.3°, 21.4°, and 23.6°, indicating that they contained both PCL and PEO components.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Antibacterial Properties of a Composite Fiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning

Zhang

Tian

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

Microbial infections due to bacteria, viruses, and molds are a serious threat to both human life and the health of other organisms. To develop inexpensive, easy-to-prepare, efficient, and portable nano-antibacterial materials, as well as to explore the antibacterial prospects of cationic antibacterial agents, in this work, six different membrane materials were prepared by the electrostatic spinning method and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR). The materials were tested for antimicrobial properties using a modified AATCC100-200 test method. Under the most suitable spinning conditions, the doping amount of the cationic antimicrobial agent, CTAB, had the greatest influence on the antimicrobial performance. The antimicrobial performance of PCL/PEO/CS/CTAB0.4 was the highest among the prepared materials, with 83.7% effectiveness against S. aureus and 99.9% against E. coli. The antimicrobial performance was found to be stable. In our study, we determined the most suitable spinning ratio to prepare an inexpensive and efficient cationic antimicrobial agent. Biodegradable, high-antimicrobial-activity antimicrobial materials can be applied as films, and this new nanofiber material has shown great potential in wound dressings and as a mask material due to its remarkable antimicrobial efficiency.

show abstract

Section: Resultsmentioning

confidence: 99%

Preparation and Antibacterial Properties of a Composite Fiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning

Zhang

Tian

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Collagen stimulates the molecular and cellular cascade of wound healing [ 16 ], promotes debridement of necrotic tissue [ 4 , 16 ], leads to the synthesis of growth factors that stimulate angiogenesis, and provides a hydrophilic environment that favors re-epithelialization [ 4 ]. Collagen acts through a hemostatic effect mechanism [ 4 , 46 ], inducing platelet activation and aggregation, resulting in the release of coagulation factors that lead to the deposition of a fibrin clot at the wound site [ 33 ] and increasing the availability of fibronectin, which plays an important role in cell endurance and is essential for the succession of the cell cycle. Collagen plays a crucial role in maintaining cell viability and preserves immune system cells such as macrophages and leukocytes [ 4 ].…”

Section: Polymersmentioning

confidence: 99%

“…Collagen dressings inhibit the activity of metalloproteinases (stagnate wound healing in the inflammatory phase), allowing the healing process to proceed [ 4 , 46 ]. In the inflammatory phase, the activation of immune cells stimulates the secretion of pro-inflammatory cytokines, recruiting fibroblasts, endothelial, and epithelial cells.…”

Section: Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

View full text Add to dashboard Cite

Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. This review offers a comprehensive overview and critical analysis of the key polymers that can constitute hydrogels, beginning with a brief contextualization of the polymers. It delves into their function, origin, and chemical structure, highlighting key sources of extraction and obtaining. Additionally, this review encompasses the main intrinsic properties of these polymers and their roles in the wound healing process, accompanied, whenever available, by explanations of the underlying mechanisms of action. It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. This can be achieved due to their role in the stimulation of angiogenesis, for example, or through the incorporation of substances like growth factors or drugs, such as antimicrobials, imparting new properties to the hydrogels. In addition to substance incorporation, the potential of hydrogels is also related to their ability to serve as a three-dimensional matrix for cell culture, whether it involves loading cells into the hydrogel or recruiting cells to the wound site, where they proliferate on the scaffold to form new tissue. The latter strategy presupposes the incorporation of biosensors into the hydrogel for real-time monitoring of wound conditions, such as temperature and pH. Future prospects are then ultimately addressed. As far as we are aware, this manuscript represents the first comprehensive approach that brings together and critically analyzes fundamental aspects of both natural and synthetic polymers constituting hydrogels in the context of cutaneous wound healing. It will serve as a foundational point for future studies, aiming to contribute to the development of an effective and environmentally friendly dressing for wounds.

show abstract

“…[17,18] It is worth mentioning that the BC can effectively absorb wound exudate because of the large specific surface area and abundant hydrophilic groups. [19,20] It can reduce the pain during dressing changes and promote healing of the wound. In particular, the 3D network structure of BC is similar to the human extracellular matrix, [21] which serves as a matrix for cell adhesion and provides support for cell growth.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose Applied in Wound Dressing Materials: Production and Functional Modification – A Review

Hou,

Xia,

Pan

et al. 2023

Macromolecular Bioscience

View full text Add to dashboard Cite

In recent years, the development of new type wound dressings has gradually attracted more attention. Bacterial cellulose (BC) is a natural polymer material with various unique properties, such as ultrafine three‐dimensional nano‐network structure, high water retention capacity and biocompatibility. These properties allow BC to be used independently or in combination with different components (such as biopolymers and nanoparticles) to achieve diverse effects. This means that BC has great potential as a wound dressing. However, systematic summaries for the production and commercial application of BC‐based wound dressings are still lacked. Therefore, this review provides a detailed introduction to the production fermentation process of BC, including various production strains and their biosynthetic mechanisms. Subsequently, with regard to the functional deficiencies of bacterial cellulose as a wound dressing, recent research progress in this area are enumerated. Finally, prospects are discussed for the low‐cost production and high‐value‐added product development of BC‐based wound dressings.This article is protected by copyright. All rights reserved

show abstract

Bioactive bacterial cellulose wound dressings for burns with collagen in-situ and chitosan ex-situ impregnation

Cited by 47 publications

References 29 publications

Preparation and Antibacterial Properties of a Composite Fiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning

Preparation and Antibacterial Properties of a Composite Fiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Bacterial Cellulose Applied in Wound Dressing Materials: Production and Functional Modification – A Review

Contact Info

Product

Resources

About