Bioactive Constituents of Brazilian Red Propolis

Trusheva, Boryana; Popova, Milena; Bankova, Vassya; Simova, Svetlana; Marcucci, María Cristina; Miorin, P.L.; Pasin, Flavia da Rocha; Tsvetkova, Iva

doi:10.1093/ecam/nel006

Cited by 195 publications

(192 citation statements)

References 23 publications

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“…Group 4A is composed of 3 propolis samples characterized by ion of m/z 601. This ion corresponds to two prenylated benzophenones isolated from red Brazilian propolis and identified by Trusheva et al [37] and which stood out as the major marker ion of red R1 Brazilian propolis in previous ESI-MS studies [19]. The samples in this group were red propolis samples from the states of Alagoas and Amazonas in Brazil, and Fig.…”

Section: Resultsmentioning

confidence: 61%

Fingerprinting of propolis by easy ambient sonic-spray ionization mass spectrometry

Sawaya

Abdelnur²,

Eberlin³

et al. 2010

Talanta

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a b s t r a c tChemical profiles of a representative set of 49 propolis ethanolic extracts collected worldwide (North and South America, Europe, Asia and Oceania) were obtained via easy ambient sonic-spray ionization mass spectrometry (EASI-MS). This simple and easily implemented fingerprinting technique analyses directly (without any pre-separation or sample manipulation) a tiny droplet of the ethanolic extract placed on a inert surface under ambient conditions. Data acquisition took about a minute per sample with no substantial sample carry-over. Extraction of propolis with ethanol by using an ultrasonic bath method gave EASI-MS data similar to the traditional maceration method, reducing total analysis time for the crude propolis resin from a week to just ca 1 h. Principal component analysis of the EASI-MS data is shown to group samples according to the plant sources of their resins, which characterizes their geographical origin.

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Section: Resultsmentioning

confidence: 61%

Fingerprinting of propolis by easy ambient sonic-spray ionization mass spectrometry

Sawaya

Abdelnur²,

Eberlin³

et al. 2010

Talanta

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“…A própolis vermelha, cuja origem botânica provém da Dalbergia ecastophyllum, é encontrada na Região Nordeste do Brasil [19][20][21][22] . Suas propriedades biológicas são atribuídas aos flavonoides e aos ácidos fenólicos 19,20,[22][23][24] , destacando-se as ações: anti-inflamatória 25 , citotóxica 23,24,26 , antiaterogênica 27 , cicatrizante 28 , regeneradora de tecido cartilaginoso e pulpar dental 29 , antioxidante 19,22,24,30 e antimicrobiana 19,20,22,30,31 .…”

Section: Um Dos Principais Microrganismos Envolvidos Neste Processo Iunclassified

“…Suas propriedades biológicas são atribuídas aos flavonoides e aos ácidos fenólicos 19,20,[22][23][24] , destacando-se as ações: anti-inflamatória 25 , citotóxica 23,24,26 , antiaterogênica 27 , cicatrizante 28 , regeneradora de tecido cartilaginoso e pulpar dental 29 , antioxidante 19,22,24,30 e antimicrobiana 19,20,22,30,31 . Esta última ação foi observada contra Candida albicans 22 , Staphylococcus aureus 19,22 e Staphylococcus mutans, apresentando resultados positivos, bem como atividade citotóxica.…”

Section: Um Dos Principais Microrganismos Envolvidos Neste Processo Iunclassified

Estudo da ação antibacteriana do extrato hidroalcoólico de própolis vermelha sobre Enterococcus faecalis

Siqueira

Dantas

Gomes

et al. 2014

Rev. odontol. UNESP

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ResumoIntrodução: A própolis é uma substância resinosa e complexa; produzida pelas abelhas, destaca-se por suas propriedades terapêuticas, como atividade antimicrobiana, anti-inflamatória e cicatrizante. Poucos trabalhos existem sobre a variedade de própolis vermelha, encontrada no Estado de Sergipe. Objetivo: Avaliar a ação antimicrobiana do extrato de própolis vermelha, coletada na região nordeste do Estado de Sergipe, contra cepas de Enterococcus faecalis. Material e método: As amostras de própolis vermelha foram coletadas em Brejo Grande-SE, Brasil, e identificadas segundo suas características sensoriais, a granulometria e requisitos físico-químicos. O teor de flavonoides no extrato seco foi determinado. Soluções de própolis vermelha (EEP) foram preparadas nas concentrações de 1%; 2,5%; 5% e 7,5%. A cepa bacteriana de referência utilizada foi Enterococcus faecalis -ATCC 29212. A atividade antibacteriana foi verificada por meio de testes in vitro (teste de difusão em disco e determinação da concentração bactericida mínima -CBM) e ex vivo (utilizando dentes humanos extraídos). No teste ex vivo, os dentes contaminados foram divididos em três grupos com dez dentes cada. O grupo 1 foi tratado com própolis a 7,5% (concentração determinada no teste CBM); o grupo 2 foi tratado como controle positivo, com solução de hipoclorito de sódio a 2,5%, e o grupo 3 foi utilizado como controle negativo, sendo tratado apenas com solução salina NaCl 0,9%. Resultado: O extrato de própolis promoveu halo de inibição comparado ao da solução de hipoclorito de sódio a 2,5%, variando entre 12 e 16 mm. Não houve crescimento bacteriano após irrigação do conduto radicular com a solução de EEP a 7,5%. Conclusão: A própolis coletada apresentou médio teor de flavonoides (1,8%) e características físico-químicas coerentes com as exigidas pelo Ministério da Agricultura. Na concentração de 7,5% de própolis vermelha, foi observado um maior potencial antibacteriano quando comparado aos demais grupos. Descritores: Própolis; bactérias; Enterococcus faecalis. AbstractIntroduction: Propolis is a complex resinous substance produced by bees that has therapeutic properties, such as antimicrobial activity, anti-inflammatory, healing. Few studies exist on the red variety of propolis, found in the state of Sergipe. Objective: Evaluation of the antimicrobial action of the extract of propolis red collected in the northeastern state of Sergipe, against strains of Enterococcus faecalis. Material and method: The red propolis samples were collected in Brejo Grande/SE -Brazil and identified according to their sensory characteristics, granulometry and physical chemical requirements. The content of flavonoids in dried extract was determined. Solutions of red propolis (EEP) were prepared at concentrations of 1%; 2.5%; 5% and 7.5%. The bacterial strain used was Enterococcus faecalis -ATCC 29212. The antibacterial activity was verified by in vitro tests (disk diffusion test and determination of minimum bactericidal concentration -CBM) and ex vivo (using human extracted...

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“…In the temperate zone, the seasonal variations in propolis composition are predominantly quantitative, indicating that bees collect propolis from the same group of plants throughout the year (Miguel et al, 2010). However, tropical propolis samples have shown differences in their chemical compositions (Trusheva et al, 2006;Cuesta-Rubio et al, 2007). The present work showed that, despite the local biodiversity, the chemical compositions of the collected propolis did not show much qualitative variation.…”

Section: Discussionmentioning

confidence: 48%

“…Formononetin, is used as a chemical marker (Cuesta-Rubio et al, 2007) for red propolis and has only been identified in red propolis samples from Brazil (Cabral et al, 2009) and Cuba (Cuesta-Rubio et al, 2007). Trusheva et al (2006) also observed the presence of isoflavonoids in Brazilian red propolis. The presence of isoflavonoids in propolis suggests new potential biological applications for this natural product.…”

Section: Discussionmentioning

confidence: 99%

Chemical markers and antifungal activity of red propolis from Sergipe, Brazil

Mendonça

Araujo

et al. 2015

Food Sci. Technol (Campinas)

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The aim of this study was to analyze the physicochemical properties and antifungal activities of the red propolis samples from Sergipe, Brazil, and also evaluate their variability throughout the year. The characterization of the hydroalcoholic extract (HPE) of the red propolis samples was performed monthly from Dctober 2009 to September 2010. The concentrations of the bioactive compounds varied during the year, but their chromatographic profiles were similar. Four compounds were identified by comparison with authentic standards. Formononetin was one of the predominant compounds in all propolis extracts. In our study, it was observed that all the propolis samples inhibited the growth of Candida species. Multivariate analysis confirmed the variations in chemical composition and color of the HPEs throughout the year. The biological activities of the HPEs were statistically significant (p<0.05), and all samples exhibited antifungal properties.

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Bioactive Constituents of Brazilian Red Propolis

Cited by 195 publications

References 23 publications

Fingerprinting of propolis by easy ambient sonic-spray ionization mass spectrometry

Fingerprinting of propolis by easy ambient sonic-spray ionization mass spectrometry

Estudo da ação antibacteriana do extrato hidroalcoólico de própolis vermelha sobre Enterococcus faecalis

Chemical markers and antifungal activity of red propolis from Sergipe, Brazil

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