Bioactive natural products from marine sponges belonging to family Hymedesmiidae

Said, Asmaa Abo Elgoud; Mahmoud, Basma Khalaf; Attia, Eman Zekry; Abdelmohsen, Usama Ramadan; Fouad, Mostafa A.

doi:10.1039/d1ra00228g

Cited by 17 publications

(20 citation statements)

References 58 publications

(93 reference statements)

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“…In 2009, (Z)-5-(4-hydroxybenzylidene)-hydantoin (phenylmethylene hydantoin) was isolated from the Red Sea sponge Hemimycale arabica . Phenylmethylene hydantoin showed potent anti-invasive and cytotoxic effects against PC3M cells, with an EC50 of 150 µM [ 75 , 76 , 77 , 78 ]. In the same year, two cyclic heptapeptides, rolloamide A and rolloamide B, isolated from the marine sponge Eurypon laughlini , demonstrated growth suppression of human prostate cell lines LNCap, PC3MM2, PC3 and DU145, with IC50 of 0.8 µM, 4.7 µM, 1.4 µM and 0.85 µM, respectively [ 79 ].…”

Section: Marine Macroorganismsmentioning

confidence: 99%

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Montuori

Hyde

Crea

et al. 2023

IJMS

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Prostate cancer is the most common cancer in men, with over 52,000 new cases diagnosed every year. Diagnostics and early treatment are potentially hindered by variations in screening protocols, still largely reliant on serum levels of acid phosphatase and prostate-specific antigen, with tumour diagnosis and grading relying on histopathological examination. Current treatment interventions vary in terms of efficacy, cost and severity of side effects, and relapse can be aggressive and resistant to the current standard of care. For these reasons, the scientific community is looking for new chemotherapeutic agents. This review reports compounds and extracts derived from marine organisms as a potential source of new drugs against prostate cancer. Whilst there are several marine-derived compounds against other cancers, such as multiple myeloma, leukemia, breast and lung cancer, already available in the market, the presently collated findings show how the marine environment can be considered to hold potential as a new drug source for prostate cancer, as well. This review presents information on compounds presently in clinical trials, as well as new compounds/extracts that may enter trials in the future. We summarise information regarding mechanisms of action and active concentrations.

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Section: Marine Macroorganismsmentioning

confidence: 99%

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Montuori

Hyde

Crea

et al. 2023

IJMS

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“…On the other hand, anchinopeptolide A (1) was found to have weaker bioactivity in these binding assays [21]. The alkaloids zarzissine (13) and p-hydroxybenzaldehyde (14) showed slight antimicrobial activity against Staphylococcus aureus (Gram-positive bacterium) and C. albicans and C. tropicalis (yeasts) [35].…”

Section: Other Biological Activitiesmentioning

confidence: 99%

“…Secondary metabolites belonging to the above-mentioned four classes have been evaluated mainly for cytotoxic activity. However, sponges of the genus Phorbas have also been reported as a source a of compounds with antimicrobial, antioxidant, isocitrate lyase (ICL) inhibition activities [14]. This work brings an overview of Phorbas secondary metabolites reported since the first study published in 1993 until 2020, and their biological activities.…”

Section: Introductionmentioning

confidence: 99%

“…The genus Phorbas belongs to the class Demospongiae, order Poecilosclerida, family Hymedesmiidae [14], being the biggest representative of the family that contains 10 accepted genera, including beyond Phorbas, Hamigera, Acanthancora, Hemimycale [15][16][17][18]. The genus Phorbas stands out in the number of isolated MNPs, but also in relation to a large number of bioactive compounds, mainly displaying cytotoxic activity [19].…”

Section: Introductionmentioning

confidence: 99%

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Exploring Chemical Diversity of <em>Phorbas</em> Sponges as a Source of Novel Lead Compounds in Drug Discovery

Caso¹,

Silva²,

Esposito³

et al. 2021

Preprint

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Porifera, commonly referred to as marine sponges, have stood out as major producers of marine natural products (MNPs). Sponges of the genus Phorbas have attracted much attention along years. They are widespread in all continents, and several structurally unique compounds have been identified from species of this genus. Terpenes, mainly sesterterpenoids, represent the great majority of secondary metabolites isolated from Phorbas species, even though several alkaloids and steroids have also been reported. Many of these compounds have shown a variety of biological activities. Particularly, Phorbas sponges have been demonstrated to be a source of cytotoxic metabolites. In addition, MNPs exhibiting cytostatic, antimicrobial and anti-inflammatory activities, have been isolated and structurally characterized. This work brings an overview of Phorbas secondary metabolites reported since the first study published in 1993 until 2020, and their biological activities.

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“…This type of diterpenoids was isolated from the New Zealand marine sponge Hamigera tarangaensis , and most of them feature a unique hamigerane ([6,6,5]) or isohamigerane ([6,7,5]) skeleton emanating from geranylgeranyl pyrophosphate (Figure ). Biological studies have shown that many of them exert significant in vitro cytotoxic activity against the HL-60 cell line . Therefore, since the first enantioselective synthesis of hamigeran B and its congeners was reported by Nicolaou and co-workers in 2001, many synthetic efforts have been devoted to the enantioselective synthesis of hamigeran B and analogues featuring a hamigerane skeleton, culminating in several elegant total syntheses .…”

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confidence: 99%

Enantioselective Total Synthesis of (−)-Hamigeran F and Its Rearrangement Product

Xiong

Chen

et al. 2022

Org. Lett.

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Herein, we report the first enantioselective total synthesis of the highly complex hamigeran diterpenoid (−)-hamigeran F and its rearrangement product. The synthetic strategy features key steps of asymmetric hydrogenation, Horner−Wadsworth−Emmons olefination, and intramolecular Friedel−Crafts acylation to construct the [6,6,5]-tricyclic skeleton bearing three consecutive stereocenters, a sequence of steps involving Rosenmund reduction, Wittig reaction, dihydroxylation to assemble the α-acetoxy ketone group, and an intramolecular aldol reaction to build the tetracyclic core structure.

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Bioactive natural products from marine sponges belonging to family Hymedesmiidae

Abstract: Natural products of marine origin exhibit extensive biological activities, and display a vital role in the exploration of new compounds for drug development.

Cited by 17 publications

References 58 publications

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

Exploring Chemical Diversity of <em>Phorbas</em> Sponges as a Source of Novel Lead Compounds in Drug Discovery

Enantioselective Total Synthesis of (−)-Hamigeran F and Its Rearrangement Product

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