Bioactive Phenolic Compounds from Aerial Parts of Plinia glomerata

Abstract

The present work describes the antinociceptive properties and chemical composition of the aerial parts of Plinia glomerata (Myrtaceae). Both of the extracts evaluated, acetonic and methanolic, showed potent antinociceptive action, when analyzed against acetic acid-induced abdominal constrictions in mice, with calculated ID 50 (mg/kg, i. p.) values of 24.8 and 3.3, respectively. Through usual chromatographic techniques with an acetonic extract, the following compounds were obtained: 3,4,3Ј-trimethoxy flavellagic acid (1), 3,4,3Ј-trimethoxy flavellagic acid 4Ј-O-glucoside (3) and quercitrin (4), which were identified based on spectroscopic data. Compounds 1 (ID 50 = 3.9 mg/kg, i. p., or 10.8 μmol/kg) and 3 (ID 50 = 1.3 mg/kg or 2.5 μmol/kg) were notably more active than some well-known analgesic drugs used here for comparison.

Further Antinociceptive Properties of Extracts and Phenolic Compounds from Plinia glomerata (Myrtaceae) Leaves

“…Considering the interesting antinociceptive profile shown by the extracts, two rare phenolic compounds, previously isolated from the acetonic extract of this plant and active against the writhing test, 3) were evaluated against the formalin test at 10 mg/kg, i.p. Compound 2 inhibited both phases of pain (77.6%, first phase; 62%, second phase).…”

Stepwise Elution of a Three‐phase Solvent System in Centrifugal Partition Extraction: A New Strategy for the Fractionation and Phytochemical Screening of a Crude Bark Extract

“…Their structures (Fig. 3) were validated by further 2D‐NMR analyses (HSQC and HMBC) and by comparison with reference NMR data from the literature (Sato, ; Serafin et al ., ). The elution of EAd2 and EAd3 by the n ‐heptane‐rich UP 0 was principally linked to their relatively high hydrophobicity, due to the absence of glycoside substituent.…”

Antifungal activity of Terminalia superba (combretaceae)

“…The 1 H-NMR spectrum (figure 3a) of compound A revealed two protons as singlet at δH 7.51 ppm, assignable to aromatic protons H-5 and H-5' respectively, by comparing with the 1 H-NMR data of ellagic acid (Nduji & Okwute, 1988;Khac et al, 1990;Adigun et al, 2000 ;Serafin et al, 2007;Thitilertdecha et al, 2010). The 1 H-NMR spectrum of compound A also showed methoxy protons at δH 4.04 ppm (6H, s), which gave correlations, in the HSQC spectrum (figure 3d), with carbon signal δC 60.94ppm.…”