Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: <i>in vitro</i> and <i>in vivo</i> evaluation

Amirthalingam, Muthukumar; Kasinathan, Narayanan; Amuthan, Arul; Mutalik, Srinivas; Reddy, M. Sreenivasa; Udupa, N.

doi:10.3109/21691401.2016.1146727

Cited by 9 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the other work, Muthukumar Amirthalingam et al fabricated the novel biocompatible PLGA-curcumin microparticle-embedded chitosan scaffold for wound healing application. Their results indicated that the existent scaffold could be used as a drug delivery system to treat the severe and chronic wounds [94].…”

Section: Poementioning

confidence: 99%

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Bakhshayesh

Annabi

Khalilov

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

193

View full text Add to dashboard Cite

The tissue engineering field has developed in response to the shortcomings related to the replacement of the tissues lost to disease or trauma: donor tissue rejection, chronic inflammation and donor tissue shortages. The driving force behind the tissue engineering is to avoid the mentioned issues by creating the biological substitutes capable of replacing the damaged tissue. This is done by combining the scaffolds, cells and signals in order to create the living, physiological, three-dimensional tissues. A wide variety of skin substitutes are used in the treatment of full-thickness injuries. Substitutes made from skin can harbour the latent viruses, and artificial skin grafts can heal with the extensive scarring, failing to regenerate structures such as glands, nerves and hair follicles. New and practical skin scaffold materials remain to be developed. The current article describes the important information about wound healing scaffolds. The scaffold types which were used in these fields were classified according to the accepted guideline of the biological medicine. Moreover, the present article gave the brief overview on the fundamentals of the tissue engineering, biodegradable polymer properties and their application in skin wound healing. Also, the present review discusses the type of the tissue engineered skin substitutes and modern wound dressings which promote the wound healing.

show abstract

Section: Poementioning

confidence: 99%

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Bakhshayesh

Annabi

Khalilov

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

193

View full text Add to dashboard Cite

show abstract

“…However, MBGs are not optimal for scaffolds because of their high brittleness and low fracture toughness and do not meet the mechanical strength requirements of clinical bone repair, especially in mesoporous form [28,33]. Synthetic bioresorbable polymers are known for their high modifiability because these polymers can be easily fabricated into complex structures [6,15,34,35]. However, their performance in cell attachment, proliferation and osteoconductivity is poor because of the lack of specific cell-recognition signals [36].…”

Section: Discussionmentioning

confidence: 99%

Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects

Cheng

Zhang

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous bioactive glass (MBG) to form a local antibiotic delivery system and then a bone tissue-engineering scaffold combining MBG and poly-(L-lactic-co-glycolic acid) (PLGA) was prepared by freeze-drying fabrication. In vitro degradation and water contact angle analysis suggested that the MBG-incorporated PLGA scaffold exhibited controlled degradability, stabilizing the pH of the surrounding environment and improved the hydrophilicity. Moreover, the presence of MBG provides a well-interconnected pore structure, to which human bone marrow-derived mesenchymal stem cells can attach, spread and proliferate, promoting upregulation of the expression of osteogenic markers. Thus, MBG/PLGA scaffolds exhibit better cytocompatibility and osteoblastic difierentiation properties compared with pure PLGA scaffolds. Vancomycin-loaded scaffolds have been found to yield sustained release that lasts for more than eight weeks in vitro. We tested the antibacterial performance of vancomycin-loaded scaffolds against Staphylococcus aureus, the most common bacteria isolated from infected bone. In vitro experiments demonstrated that loading vancomycin onto the scaffold promoted antibacterial activity and inhibited biofilm formation without deleterious effect on cytocompatibility. In conclusion, the novel inorganic-organic composites are considered potential materials for the treatment of infected bone defects.

show abstract

“…Curcumin-loaded, PLGA-embedded chitosan scaffolds were successfully studied for the treatment of chronic wounds. The porous structure of the scaffold supported cell growth and proliferation in Vero cells (in vitro), and the curcumin-loaded composite scaffold displayed more potent antibacterial property against Staphylococcus aureus than the plain scaffold [103]. The novel PLGA-and PLA-based hybrid nanofibers were prepared by electrospinning method, which helped achieve a sustained release of loaded thymosin beta-4.…”

Section: Synthetic Polymer-based Biomaterialsmentioning

confidence: 99%

Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

Kumar

Abrahamse

2020

IJMS

View full text Add to dashboard Cite

Recent advancement in nanotechnology has provided a wide range of benefits in the biological sciences, especially in the field of tissue engineering and wound healing. Nanotechnology provides an easy process for designing nanocarrier-based biomaterials for the purpose and specific needs of tissue engineering applications. Naturally available medicinal compounds have unique clinical benefits, which can be incorporated into nanobiomaterials and enhance their applications in tissue engineering. The choice of using natural compounds in tissue engineering improves treatment modalities and can deal with side effects associated with synthetic drugs. In this review article, we focus on advances in the use of nanobiomaterials to deliver naturally available medicinal compounds for tissue engineering application, including the types of biomaterials, the potential role of nanocarriers, and the various effects of naturally available medicinal compounds incorporated scaffolds in tissue engineering.

show abstract

Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation

Cited by 9 publications

References 22 publications

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass/PLGA composite scaffolds for bone regeneration in infected bone defects

Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

Contact Info

Product

Resources

About