Bioactivity evaluation of amino acid-conjugates with protein versus cellulose based conjugates and extracted flavonoids

Basta, Altaf H.; Lotfy, Vivian F.; Ghaly, Neveen S.; Nabil, Marian; Mohamed, Khaled Salah

doi:10.1016/j.jddst.2020.101924

Cited by 8 publications

(5 citation statements)

References 43 publications

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“…One study indicated that treatment with naringin alone or in combination with the sodium salt of carboxymethyl cellulose-phenyl alanine and sodium caseinate-phenyl alanine reduced viability and proliferation of MCF-7 cell line. Besides, naringin in hybrids had a greater cytotoxic effect in comparison to naringin alone ( Basta et al, 2020 ). Moreover, treatment with naringin and its metal complexes decreased cell viability and proliferation and increased apoptosis in MCF-7 cell line ( Atta et al, 2019 ).…”

Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

“…In another study, the antitumor effect of naringin was examined alone and in hybrids with SCMC-PA and SC-PA conjugates against the HCT116 colon cancer cells. Results showed that naringin, individually or in hybrids, reduced the proliferation and viability of colon cancer cell lines ( Basta et al, 2020 ). Naringin also increased the inhibitory activity of trypsin and enhanced the antiplatelet aggregation activity and cytotoxic activity toward SNU-C4 human colon cancer cells ( Kim et al, 1998 ).…”

Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

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A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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Background: Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers.Methods: Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria.Results: Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion.Conclusion: The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.

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Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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“…It is worth noting that the TMC achieved superior inhibition in colon cancer cell line proliferation in comparison with previous approved anticancer agents based on biopolymer-amino acid conjugates (CMC-PA and SC-PA), as well as flavonoid (rutin). 34 Its concentrations to inhibit 50% and 90% of colon cell lines were 28.4 and 55.8 (μg mL -1 ), while these values for conjugates and flavonoids (Table 3) were in the ranges 44.1-74.3 and 83.6-118.1 μg mL -1 . Moreover, these doses were less than those for the positive control, doxrobicin (37.6 and 65.11 μg mL -1 ).…”

Section: Cytotoxic Activity Of Trimethyl Chitosanmentioning

confidence: 96%

Impact of amino acids on enhancing trimethyl chitosan as a nontoxic antiproliferative active biopolymer

Basta

Lotfy

El-Manawaty

et al. 2021

Biofuels Bioprod Bioref

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This work evaluates the toxicity of trimethyl chitosan (TMC), which prevents its use as an antiproliferative active compound. We report our trial to enhance its safe application by chelating with various amino acids (phenylalanine, glycine and lysine). The safety evaluation was achieved by studying the behavior of TMC-amino acid chelates against two normal human cell lines (BJ1 and RPE1), in comparison with a negative control and doxrobicin (positive control) standard samples. The results obtained show that phenylalanine and lysine play an effective role in enhancing the safety of TMC against normal cell lines, together with providing high thermal stability. Phenylalanine is superior in synthesized anticancer agents. It had IC 50 values against colon HCT116 and breast cancer MCF-7cancer cell lines of 68.7 and 51.4 μg mL -1 This compound is more acceptable than the previous reported rutin flavonoid as an anticancer agent against HCT116 cell lines.

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“…The functionalized paper, carbon nanostructures materials, semiconductor, water purification adsorbent, liquid crystal materials and the formaldehyde-free adhesive are literature applications for the cellulose-based products (Hosny et al , 1997; Vimala et al , 2009; Thakur et al , 2013; El-Saied et al , 2016; Canejo et al , 2017; Lotfy et al , 2018; Ravichandran et al , 2018; Basta et al , 2011, 2013, 2014, 2019; Ates et al , 2020). Additionally, there are medical and agriculture applications for the cellulose and its derivatives which are produced in form of hydrogel formulation (Lotfy and Basta, 2020; Lotfy et al , 2020; Hanna et al , 2020; Khalf-Alla et al , 2020; Basta et al , 2020, 2021a, 2021b, 2021c, 2021d, 2021e; Basta and Lotfy, 2021).…”

Section: Introductionmentioning

confidence: 99%

Selective route for enhancing liquid crystal-based hydroxylpropyl cellulose by esterification

Basta

Lotfy

Micky

et al. 2022

PRT

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Purpose This paper aims to study the effect of hydrolysis route of hydroxypropyl cellulose (HPC) on its esterification performance as liquid crystal material. The assessment was carried out from the data of spectra (Fourier-transform infrared analysis [FTIR] and 1H-nuclear magnetic resonance [1H-NMR]), thermal stability as well as optical properties via forming ordered mesophases at lower concentration than HPC. Design/methodology/approach The HPC was hydrolyzed by hydrochloric acid-methanol at times 9 and 18 h, and the products were esterified by decanoyl chloride. The products of hydrolysis and the esterification were characterized by FTIR, NMR, nonisothermal analysis, thermo-gravimetric analysis (TGA) and polarizing microscope to evaluate the role of degree of substitution of HPC as a result of hydrolysis, on esterification degree, thermal stability and thermal and liquid crystal behavior of the final esterified HPC. Findings The pretreatment by acid hydrolysis of HPC was successful for synthesizing novel cholesteric hydroxypropyl cellulose ester. The data of FTIR and TGA thermal analysis proved that hydrolysis and esterification of HPC with the decanoyl chain significantly enhanced crystallinity of this cellulose derivative from 0.57 to (1.7–1.9). Moreover, they provided products with superior thermal stability than pure HPC, as noticed from increasing the activation energy of degradation (Ea) from 514.3 to 806.2 kJ/mol. The NMR measurement proved that hydrolysis of HPC for 9 and 18 h decreased the degree of substitution from 3 to 2.1 and 1.3, respectively. Moreover, the esterified HPC showed a promising birefringence texture (chiral nematic) besides decreasing the critical concentration from 30% for HPC to 10% for the esterified unhydrolyzed HPC, while superior decreasing to 1–5% was observed for the esterified hydrolyzed HPC. Research limitations/implications There are two stages for preparation of decanoyl ester hydroxypropyl cellulose. At the first stage, HPC was treated by hydrochloric acid-methanol in ratio 1:10 at times 9 and18 h. At the second stage, HPC and hydrolyzed HPC were refluxed with decanoyl chloride (1:6) in presence of nitrogen atmosphere. The final product was precipitated by distilled water. Practical implications There are two stages for preparation of decanoyl ester hydroxypropyl cellulose. At the first stage, HPC was treated by hydrochloric acid-methanol in ratio 1:10 at times 9 and18 h. At the second stage, HPC and hydrolyzed HPC were refluxed with decanoyl chloride (1:6) in presence of nitrogen atmosphere. The final product was precipitated by distilled water. Originality/value The novelty of this work was focused on enhancing the crystallinity, thermal stability and liquid crystal behavior of esterified HPC, via decreasing the degree of substitution and consequently the type of OH group subjected to esterification. The decanoyl ester formation from the hydrolyzed hydroxypropyl cellulose is able to form ordered mesophases at even low concentration (promising birefringence texture at concentrations 1–5%). It is worthy to notice that the investigated route is able to omit the role of graphene oxide in promoting the liquid crystal behavior of HPC, as it hasn't any effect on critical concentration. This work will promote the use of HPC in technological applications, e.g. high modulus fibers and electronic devices.

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Bioactivity evaluation of amino acid-conjugates with protein versus cellulose based conjugates and extracted flavonoids

Cited by 8 publications

References 43 publications

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

Impact of amino acids on enhancing trimethyl chitosan as a nontoxic antiproliferative active biopolymer

Selective route for enhancing liquid crystal-based hydroxylpropyl cellulose by esterification

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