Bioactivity of ferrimagnetic glass-ceramics in the system FeOFe2O3CaOSiO2

Ebisawa, Yukihiro; Miyaji, Fumiaki; Kokubo, Tadashi; Ohura, K.; Nakamura, Takashi

doi:10.1016/s0142-9612(97)00067-7

Cited by 142 publications

(79 citation statements)

References 15 publications

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“…Soaked during two weeks in a simulated body fluid, the material had a bioactive behavior shown by the hydroxyapatite layer deposited at its surface [228]. Bioactivity of glass-ceramic was also studied by Ebisawa and coworkers and the same observations concerning the formation of apatite layer on the glass-ceramic surface when immersed in a simulated body fluid were made [229]. Ceramic prepared by mixing a powder system (SiO 2 -…”

Section: Thermotherapy Through Intraosseous Implantsmentioning

confidence: 99%

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Mohamed

Borchard

Jordan

2012

Journal of Drug Delivery Science and Technology

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Hyperthermia, an established adjuvant in cancer treatment, potentiates the effects of anticancer drugs and synergetic combination can be obtained improving the therapeutic outcome. Bone metastases may benefit from this combination when treated through in situ forming implants. Once loaded with magnetizable (nano-) particles and antineoplastic agents, these implants allow for the local application of magnetically-induced hyperthermia and the release of an anticancer drug. The implant can be heated applying an external magnetic field, sensitizing the surrounding tumoral tissues, while releasing the chemotherapeutic agent.Moreover, bone implants provide mechanical support to the weakened bone and consequently relieve pain.This review gives an overview of the current knowledge as well as the rationale of combining locally both magnetic hyperthermia and chemotherapy using in situ forming implants in the field of bone metastases treatment. KeywordsInduced hyperthermia, chemotherapy, drug delivery systems, in situ forming implants, iron oxide nanoparticles, bone metastases, cementoplasty, vertebroplasty 3

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Section: Thermotherapy Through Intraosseous Implantsmentioning

confidence: 99%

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Mohamed

Borchard

Jordan

2012

Journal of Drug Delivery Science and Technology

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“…13 By means of an external magnetic field, the implant supplies heat to the tumor on the basis of its chemical composition and microstructure. In this sense, metallic implants, nanoparticles, and magnetic glass ceramics supply heat because of eddy currents, 11 Neel losses, 14 and hysteretic losses, 15 respectively. In the last years, there has been a growing interest for this kind of implants.…”

Section: Introductionmentioning

confidence: 99%

Glass–glass ceramic thermoseeds for hyperthermic treatment of bone tumors

Ruiz

Serrano

Arcos

et al. 2006

J Biomedical Materials Res

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Implantable thermoseeds are synthesised from mixtures of a melt-derived glass with composition SiO(2) (40)-CaO(40)-Fe(2)O(3)(20) (mol%) and a sol-gel glass with composition SiO(2)(58)-P(2)O(5)(6)-CaO(36) (mol%). Structural, textural and magnetic properties of the samples are evaluated. In vitro bioactivity is assessed in order to determine the potential capability to bond to living bone. In spite of the low textural properties of the material, a bioactive behavior is observed as a result of the sol-gel glass content. Although the crystallization of the glass ceramic provides the magnetic phase, the presence of sol-gel glass modifies the magnetic properties, improving the heating power. For the first time, hyperthermia heating experiments as well as preliminary biocompatibility assays have been carried out for this kind of material. The ability to reach hyperthermic temperature range together with the bioactive behavior makes this biomaterial a very promising candidate for bone cancer treatment.

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“…[11][12][13][14][15][16][17] In previous research works, structural, thermal, and magnetic properties, together with the in vitro reactivity of ferrimagnetic glass-ceramics belonging to the system SiO 2 -Na 2 O-CaO-P 2 O 5 -FeO-Fe 2 O 3 were investigated. [18][19][20] As other silica-based bioactive glass-ceramics, these materials could be surface activated in order to expose active sites, prone to the bonding to several kinds of molecules, including antineoplastic agents.…”

mentioning

confidence: 99%

Surface Activation of a Ferrimagnetic Glass–Ceramic for Antineoplastic Drugs Grafting

et al. 2010

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A ferrimagnetic glass–ceramic, belonging to the system SiO2–Na2O–CaO–P2O5–FeO–Fe2O3, has been studied as potential carrier for antineoplastic agents, in order to exploit the combination of hyperthermia and chemotherapy. Different material pre‐treatments, such as ultrasonic washing, water, or simulated body fluid dipping, were evaluated to promote the surface activation of the glass–ceramic, i.e., the hydroxyl groups formation on it. X‐ray photoelectron spectroscopy, scanning electron microscopy, energy dispersion spectrometry, and wettability measurements were performed to observe the samples surface modification. The best results in terms of free hydroxyl groups exposition were obtained by dipping the samples in distilled water for 7 days at 37 °C. Two different anticancer drugs were selected in order to test the reactivity of the activated surface: cisplatinum and doxorubicin. The uptake and release of doxorubicin and cisplatinum were evaluated on glass–ceramic powders, by using UV–Visible spectrometry and graphite furnace atomic absorption spectroscopy, respectively. After 1 day of uptake at 37 °C, the quantity of doxorubicin incorporated into the glass–ceramic is 77 ± 7 wt%, while only 42 ± 9.6 wt% of cisplatinum is grafted onto the material surface. For both antitumoral agents, the maximum drug release after soaking in aqueous solutions at 37 °C was obtained in few hours, with a randomly distributed kinetics trend.

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Bioactivity of ferrimagnetic glass-ceramics in the system FeOFe2O3CaOSiO2

Cited by 142 publications

References 15 publications

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Glass–glass ceramic thermoseeds for hyperthermic treatment of bone tumors

Surface Activation of a Ferrimagnetic Glass–Ceramic for Antineoplastic Drugs Grafting

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