Bioadhesive microspheres: I. A novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa

Mucoadhesive Microspheres for Controlled Drug Delivery

“…From a single tensile experiment, 11 mucoadhesive parameters can be analyzed out of which 3 are direct predictors of the bioadhesive potential. 48) The CAHN instrument, although a powerful tool has inherent limitations in its measurement technique, makes it better suited for large microspheres (with a diameter of more than 300 mm) adhered to tissue in vitro. Therefore, many new techniques have been developed to provide quantitative information of mucoadhesive interactions of the smaller microspheres.…”

“…A simulated physiologic flow of fluid is introduced in the chamber and movement of microsphere is monitored using video equipment attached to a goniometer, which also monitors the static and dynamic behavior of the microparticule. 48) OTHER TESTS TO MEASURE THE ADHESIVE STRENGTH Adhesion Number Adhesion number for mucoadhesive microspheres is determined as the ratio of the number of particles attached to the substrate to the total number of applied particles, expressed as a percentage. The adhesion strength increases with an increase in the adhesion number.…”

Desenvolvimento, caracterização e avaliação de sistemas microestruturados para veiculação de ácido retinóico na pele

“…Vários relatos na literatura utilizam interações entre os grupos amina da quitosana e os grupos carboxilatos de vários ácidos carboxílicos e seus anidridos para obter compostos com características diferentes da molécula de quitosana original, particularmente para aumentar a solubilidade, melhorar propriedades mucoadesivas e preparar micro/nanopartículas (DON et al, 2005;BODNAR et al, 2005;SHIMIZU et al, 2005;KAST et al, 2001;ROGOVINA et al, 2000;SASHIWA et al, 2003). Vários estudos têm mostrado que polímeros com carga constituem bons agentes mucoadesivos (PARK; ROBINSON, 1984;CHIKENING;JACOB;MATHIOWITZ, 1992;CHIKENING;MATHIOWITZ, 1995;CH'NG et al, 1985).…”

Formulation and Evaluation of Diazepam-Loaded Intravaginal Alginate Beads: An Investigation Study for the Treatment of Pelvic Floor Dysfunction

“…The reduction of the bioadhesion strength could be discussed on the basis of the surface charge density. An increase in the extent of cross-linking resulted in a significant decrease in the surface-negative charge on the prepared alginate beads and consequently decreased the bioadhesion strength [38]. On incorporation of PL, PC, or XG within the alginate beads in a ratio of 1:1:1, the bioadhesion strength of the resultant beads increased to 74.2±1.8 (F6), 80.2±2.1 (F8), and 79.5±2.1 (F10), respectively, compared to F1 (71.5±1.3).…”