BIOAMBIENT.ES study protocol: rationale and design of a cross-sectional human biomonitoring survey in Spain

Pérez‐Gómez, Beatriz; Pastor-Barriuso, Roberto; Cervantes-Amat, Marta; Esteban, Marta; Ruiz-Moraga, Montserrat; Aragonés, Núria; Pollán, Marina; Navarro, Carmen; Calvo, Eva; Román, Javier San; López‐Abente, Gonzalo; Castaño, Argelia

doi:10.1007/s11356-012-1320-3

Cited by 42 publications

(18 citation statements)

References 21 publications

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“…In addition to NHANES, several large biomonitoring programs have been conducted in European and North American countries over the last decade (Cerna et al, 2012; Den Hond et al, 2015; Fréry et al, 2012; Haines and Murray, 2012; Kolossa-Gehring et al, 2012; Mørck et al, 2015b; Perez-Gomez et al, 2013; Schoeters et al, 2012). Large-scale birth cohorts are also increasingly publishing biomonitoring results from their study populations (Guxens et al, 2012; Kawamoto et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…These included metals, persistent chemicals, such as organochlorines, and non-persistent chemicals, such as phthalates, phytoestrogens and pesticides. We compared their concentrations with those of U.S. women of child-bearing age who participated in NHANES 2005–2012 and with other international biomonitoring studies (Cerna et al, 2012; Den Hond et al, 2015; Fréry et al, 2012; Haines and Murray, 2012; Kolossa-Gehring et al, 2012; Mørck et al, 2015b; Perez-Gomez et al, 2013; Schoeters et al, 2012). We used PCA to quantify the correlation of biomarkers between and within chemical classes.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

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Background Current exposure assessment research does not sufficiently address multi-pollutant exposure and their correlations in human media. Understanding the extent of chemical exposure in reproductive-aged women is of particular concern due to the potential for in utero exposure and fetal susceptibility. Objectives The objectives of this study were to characterize concentrations of chemical biomarkers during preconception and examine correlations between and within chemical classes. Methods We examined concentrations of 135 biomarkers from 16 chemical classes in blood and urine from 73 women aged 18–40 enrolled in Snart Foraeldre/Milieu, a prospective cohort study of pregnancy planners in Denmark (2011–2014). We compared biomarker concentrations with United States similarly-aged, non-pregnant women who participated in the National Health and Nutrition Environmental Survey (NHANES) and with other international biomonitoring studies. We performed principal component analysis to examine biomarker correlations. Results The mean number of biomarkers detected in the population was 92 (range: 60–108). The most commonly detected chemical classes were phthalates, metals, phytoestrogens and polycyclic aromatic hydrocarbons. Except blood mercury, urinary barium and enterolactone, geometric means were higher in women from NHANES. Chemical classes measured in urine generally did not load on a single component, suggesting high between-class correlation among urinary biomarkers, while there is high within-class correlation for biomarkers measured in serum and blood. Conclusions We identified ubiquitous exposure to multiple chemical classes in reproductive-aged Danish women, supporting the need for more research on chemical mixtures during preconception and early pregnancy. Inter- and intra-class correlation between measured biomarkers may reflect common exposure sources, specific lifestyle factors or shared metabolism pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

View full text Add to dashboard Cite

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“…(INE, 2009). Since we opted for efficiency, we assumed the limitation that this part of the population would be out of our scope (Pérez-Gómez et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The detailed design of the nationwide cross-sectional epidemiological study BIOAMBIENT.ES, as well as the ethical approval, has been described previously (Pérez-Gómez et al, 2013). In summary, participants were recruited among employed people older than 16 years, living in Spain at least for the 5 years previous to the study, which underwent their annual occupational medical check-up in health facilities run by Societies for Prevention of IBER-MUTUAMUR, MUTUALIA, MC-PREVENCIÓN, MUGATRA, UNIMAT PREVENCIÓN, and PREVIMAC from March 2009 to July 2010.…”

Section: Methodsmentioning

confidence: 99%

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Urinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project

et al. 2015

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Erfassung der Humanexposition mit organischen Verbindungen in Innenraumumgebungen

Salthammer

Zhang

et al. 2018

Angewandte Chemie

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Die Rolle von Chemikalien in Innenraumumgebungen ist seit langem Gegenstand der Forschung. Die meisten der potenziellen Zielsubstanzen sind leichtflüchtige, flüchtige und schwerflüchtige organische Verbindungen (VVOCs, VOCs und SVOCs). In Abhängigkeit von ihren physikalischen Eigenschaften und Stoffübergangsbedingungen verteilen sie sich in oder zwischen der Gasphase, der Partikelphase, dem Hausstaub, Oberflächenfilmen, der Kleidung und anderen Textilien sowie Haut und Haaren der Bewohner. Demzufolge müssen Inhalation, Ingestion und dermale Aufnahme als relevante Wege für die Expositions‐Charakterisierung im Wohnbereich berücksichtigt werden. Die Exposition mit VVOCs, VOCs und SVOCs kann durch Messung ihrer Konzentrationen in den jeweiligen Innenraumkompartimenten oder durch Bestimmung der Zielverbindungen und/oder ihrer Metaboliten im Urin oder Blut erfasst werden. Die verschiedenen Expositionswege erfordern oft die Kombination eines komplexen und interdisziplinären theoretischen Hintergrunds mit experimentellen Methoden. Demzufolge bedarf es einer engen Kommunikation und Zusammenarbeit zwischen Chemikern und Expositionsforschern, um ein besseres Verständnis der Humanexposition mit chemischen Substanzen in verschiedenen Innenraumumgebungen zu erlangen. Eingebettet in den toxikologischen Kontext ist dies die Grundlage für die Erfassung von Gesundheitsrisiken und die Bestimmung von Kontrollstrategien oder ‐ansätzen zur Begrenzung solcher Risiken.

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BIOAMBIENT.ES study protocol: rationale and design of a cross-sectional human biomonitoring survey in Spain

Cited by 42 publications

References 21 publications

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Urinary polycyclic aromatic hydrocarbon metabolites levels in a representative sample of the Spanish adult population: The BIOAMBIENT.ES project

Erfassung der Humanexposition mit organischen Verbindungen in Innenraumumgebungen

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