Bioavailability of all-trans and cis–Isomers of Lycopene

Boileau, Thomas; Boileau, Amy C.; Erdman, John W.

doi:10.1177/153537020222701012

Cited by 322 publications

(255 citation statements)

References 39 publications

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“…Rats that received PE or PF were pre-fed a 10% tomato powder diet in an attempt to create a tomato-fed state comparable to that of typical Western men. The F344 rat model was used in this study as our laboratory has previously utilized the F344 rat to evaluate 10% tomato powder or LYC consumption and prostate cancer risk [11,18,21,22]. Moreover, the dorsolateral lobe of the F344 rat prostate is similar to that of humans, both histological and in terms of hormonal responsiveness [23].…”

Section: Discussionmentioning

confidence: 99%

Phytoene, phytofluene, and lycopene from tomato powder differentially accumulate in tissues of male Fisher 344 rats

Campbell¹,

Engelmann²,

Lila³

et al. 2007

Nutrition Research

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Tomato product consumption is inversely related to prostate cancer incidence, and lycopene (LYC) has been implicated in reduced prostate cancer risk. The contribution of other tomato carotenoids, phytoene (PE) and phytofluene (PF), towards prostate cancer risk has not been adequately studied. The relative uptake and tissue distribution of tomato carotenoids are not known. We hypothesize that PE and PF are bioavailable from a tomato powder diet or from a purified source and accumulate in androgen-sensitive tissues. In this study, 4 wk old male Fisher 344 rats were pre-fed an AIN-93G powder diet composed of 10% tomato powder containing PE, PF, and LYC (0.015, 0.012, and 0.011 g/kg diet, respectively). After 30 d tomato powder feeding, hepatic PF concentrations (168 ± 20 nmol/ g) were higher than PE or LYC (104 ± 13 and 104 ± 13 nmol/g, respectively). In contrast, LYC, followed by PF, had the highest accumulation of the measured carotenoids in the prostate lobes and seminal vesicles. When tomato powder-fed rats received a single oral dose of either ∼2.7 mg PE or PF, an increase in the dosed carotenoid concentration was observed in all measured tissues, except the adrenal. Percent increases of PF were greater than that of PE in liver, serum, and adipose (37, 287 and 49% versus 16, 179 and 23%, respectively). Results indicate that the relative tomato carotenoid biodistribution differs in liver and androgen-sensitive tissues, suggesting that minor changes in the number of sequential double bonds in carotenoid structures alter absorption and/or metabolism of tomato carotenoids.

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Section: Discussionmentioning

confidence: 99%

Phytoene, phytofluene, and lycopene from tomato powder differentially accumulate in tissues of male Fisher 344 rats

Campbell¹,

Engelmann²,

Lila³

et al. 2007

Nutrition Research

Self Cite

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“…Factors such as certain fibers, fat substitutes, plant sterols and cholesterol-lowering drugs can interfere with the incorporation of lycopene into micelles, thus lowering its absorption (Boileau et al, 2002). Several clinical trials have also shown the bioavailability of lycopene from processed tomato products (Table 1).…”

Section: Bioavailability Of Lycopenementioning

confidence: 99%

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

2006

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Objective: To review the effects of tomato product supplementation, containing lycopene, on biomarkers of oxidative stress and carcinogenesis in human clinical trials. Results: Supplementation of tomato products, containing lycopene, has been shown to lower biomarkers of oxidative stress and carcinogenesis in healthy and type II diabetic patients, and prostate cancer patients, respectively. Processed tomato products like tomato juice, tomato paste, tomato puree, tomato ketchup and tomato oleoresin have been shown to provide bioavailable sources of lycopene, with consequent increases in plasma lycopene levels versus baseline. Dietary fats enhance this process and should be consumed together with food sources of lycopene. The mechanisms of action involve protection of plasma lipoproteins, lymphocyte DNA and serum proteins against oxidative damage, and anticarcinogenic effects, including reduction of prostate-specific antigen, upregulation of connexin expression and overall decrease in prostate tumor aggressiveness. There is limited in vivo data on the health benefits of lycopene alone. Most of the clinical trials with tomato products suggest a synergistic action of lycopene with other nutrients, in lowering biomarkers of oxidative stress and carcinogenesis. Conclusions: Consumption of processed tomato products, containing lycopene, is of significant health benefit and can be attributed to a combination of naturally occurring nutrients in tomatoes. Lycopene, the main tomato carotenoid, contributes to this effect, but its role per se remains to be investigated.

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“…Thus the cis form found in processed tomatoes had a better bioavailability than the trans form because they were very short and more soluble in bile salts, and thus are better incorporated into the chylomicrons (Erdman, 2005). It could have been chemically degraded by the acid of the stomach or modified enzymatically at the level of mucus cells (Boileau et al, 2002).…”

Section: Table 5bmentioning

confidence: 99%

Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice)

et al. 2007

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Background: Vitamin A deficiency is a public health problem in Cameroon. Data on the bioavailability of carotenoid in fruits currently consumed in Cameroon are scarce. Objective: To assess the systemic levels of carotenoids from mangoes and papaya consumed as juice, fresh or dried slices. Methods: Two groups of seven healthy volunteers (24 and 25 years of age; body mass index: 21 and 22 kg/m 2 respectively for subjects fed mango and papaya), were submitted to three types of meal treatments (juice, fresh and dried fruit). On the experiment day, meals served to fasting subjects during breakfast, included bread, yogurt and one of the three forms of fruit. All the treatments lasted only one day during which blood samples were collected three times; during fasting (T 0 ), 4 h (T 4 ) and 8 h (T 8 ) after the test meal. The carotenoids and retinol contents were analysed by high-performance liquid chromatography method. Results: From the major carotenoids present in papaya and mangoes, lutein, a-carotene and b-carotene were found in considerable amounts. Lycopene and cryptoxanthin that were the major carotenoids in papaya samples appeared in low amounts in the chylomicrons. Significant correlations were observed between these carotenoids (at T 0 , T 4 and T 8 ). The three forms of consumption contributed to the rise of serum retinol levels. A comparison between the three forms revealed that papaya and mangoes consumed in form of juice or fresh fruit are the best forms because they had higher bioavailability values. Conclusion: Association of these different forms of consumptions could lead to a better availability of these fruits throughout the year and therefore efficiently contribute to improve vitamin A status of the population.

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Bioavailability of all-trans and cis–Isomers of Lycopene

Cited by 322 publications

References 39 publications

Phytoene, phytofluene, and lycopene from tomato powder differentially accumulate in tissues of male Fisher 344 rats

Phytoene, phytofluene, and lycopene from tomato powder differentially accumulate in tissues of male Fisher 344 rats

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice)

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