Bioavailability of Vitamin B12 from Dairy Products Using a Pig Model

Dalto, Danyel Bueno; Audet, Isabelle; Girard, C.L.; Matte, J. J.

doi:10.3390/nu10091134

Cited by 16 publications

(6 citation statements)

References 28 publications

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“…Greibe [ 48 ] believed that the cobalamin content in milk (4.0–5.0 µg/kg) was moderate, although its bioavailability was considered high [ 113 ]. On the contrary, for Franco-López et al [ 37 ] and Bueno-Dalto et al [ 114 ], dairy products are an ideal source of vitamin B12, since it is present naturally and abundantly in cow’s milk [ 113 ]. In addition, it is a very stable molecule, which is not destroyed by daylight or prolonged storage [ 37 ], while radiation or heat treatments cause variable losses [ 37 , 110 , 111 ], being pasteurization and UHT (Ultra High Temperature) the ones that cause the least effects [ 110 , 111 ].…”

Section: Diagnosticmentioning

confidence: 99%

Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update

González-Montaña

Escalera-Valente

Alonso

et al. 2020

Animals

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Cobalt, as a trace element, is essential for rumen microorganisms for the formation of vitamin B12. In the metabolism of mammals, vitamin B12 is an essential part of two enzymatic systems involved in multiple metabolic reactions, such as in the metabolism of carbohydrates, lipids, some amino acids and DNA. Adenosylcobalamin and methylcobalamin are coenzymes of methylmalonyl coenzyme A (CoA) mutase and methionine synthetase and are essential for obtaining energy through ruminal metabolism. Signs of cobalt deficiency range from hyporexia, reduced growth and weight loss to liver steatosis, anemia, impaired immune function, impaired reproductive function and even death. Cobalt status in ruminant animals can be assessed by direct measurement of blood or tissue concentrations of cobalt or vitamin B12, as well as the level of methylmalonic acid, homocysteine or transcobalamin in blood; methylmalonic acid in urine; some variables hematological; food consumption or growth of animals. In general, it is assumed that the requirement for cobalt (Co) is expressed around 0.11 ppm (mg/kg) in the dry matter (DM) diet; current recommendations seem to advise increasing Co supplementation and placing it around 0.20 mg Co/kg DM. Although there is no unanimous criterion about milk production, fattening or reproductive rates in response to increased supplementation with Co, in some investigations, when the total Co of the diet was approximately 1 to 1.3 ppm (mg/kg), maximum responses were observed in the milk production.

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Section: Diagnosticmentioning

confidence: 99%

Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update

González-Montaña

Escalera-Valente

Alonso

et al. 2020

Animals

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“…Besides, it is more likely that the reabsorption of vitamin B 12 in the gut, which affects the distribution of vitamin B 12 in the peripheral compartment. Besides, a previous study suggested that the food matrix affects the absorption of vitamin B 12 ; it would be related to the rate of the vitamin release from this food matrix in the intestine [36].…”

Section: Discussionmentioning

confidence: 99%

Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model

Yang

Wang

et al. 2021

Agriculture

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This study was performed to evaluate the plasma vitamin kinetic behavior following oral vitamin supplement administration in pigs, and to determine the bioavailability of vitamins. A total of 36 pigs (fitted with jugular catheters) with an average body weight of 25 ± 2.24 kg were divided into three treatment groups: (1) placebo, (2) non-microencapsulated multivitamins supplement, or (3) lipid matrix microencapsulated multivitamins supplement. The blood samples were obtained starting pre-meal until 72 h post-meal for plasma vitamin analysis. Pharmacokinetic parameters were modeled with a non-compartmental method. The AUC (Area under the curve) from the time of dosing to the time of the last observation, Cmax (Maximum observed concentration), and MRT (Mean residence time) of α-tocopherol from oral non-microencapsulated supplement were significantly lower than oral microencapsulated supplement (p < 0.01). The average relative bioavailability of vitamin A (VA) and vitamin E (VE) from microencapsulated supplement was greater than that from non-microencapsulated supplement, but relative bioavailability of vitamin K3 (VK3) and water-soluble vitamins from microencapsulated supplement was lower than non-microencapsulated supplement. The AUC and Cmax of menadione, thiamine, and riboflavin from microencapsulated supplement were significantly lower than these parameters from oral non-microencapsulated supplement. Lipid matrix microencapsulation was able to delay absorption and improved the bioavailability of VE, whereas there were limited effects of microencapsulation on vitamin D (VD), VK3, and water-soluble vitamins.

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“…Average BW at surgery was 45.6 ± 3.9 kg at 80.5 ± 4.9 days of age. The surgery procedure has been described by Hooda et al [38] and modified by Dalto et al [39]. Briefly, a catheter was inserted into the portal vein at approximately 2.5 cm before its entry into the liver, and another catheter was inserted through the carotid artery up to the junction between the carotid and subclavian arteries.…”

Section: Animals Surgeries and Treatmentsmentioning

confidence: 99%

Assessment of In Vitro Bioaccessibility and In Vivo Oral Bioavailability as Complementary Tools to Better Understand the Effect of Cooking on Methylmercury, Arsenic, and Selenium in Tuna

Charette

Dalto

Rosabal

et al. 2021

Toxics

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Fish consumption is the main exposure pathway of the neurotoxicant methylmercury (MeHg) in humans. The risk associated with exposure to MeHg may be modified by its interactions with selenium (Se) and arsenic (As). In vitro bioaccessibility studies have demonstrated that cooking the fish muscle decreases MeHg solubility markedly and, as a consequence, its potential absorption by the consumer. However, this phenomenon has yet to be validated by in vivo models. Our study aimed to test whether MeHg bioaccessibility can be used as a surrogate to assess the effect of cooking on MeHg in vivo availability. We fed pigs raw and cooked tuna meals and collected blood samples from catheters in the portal vein and carotid artery at: 0, 30, 60, 90, 120, 180, 240, 300, 360, 420, 480 and 540 min post-meal. In contrast to in vitro models, pig oral bioavailability of MeHg was not affected by cooking, although the MeHg kinetics of absorption was faster for the cooked meal than for the raw meal. We conclude that bioaccessibility should not be readily used as a direct surrogate for in vivo studies and that, in contrast with the in vitro results, the cooking of fish muscle did not decrease the exposure of the consumer to MeHg.

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Bioavailability of Vitamin B12 from Dairy Products Using a Pig Model

Cited by 16 publications

References 28 publications

Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update

Relationship between Vitamin B12 and Cobalt Metabolism in Domestic Ruminant: An Update

Determination and Evaluation of Bioavailability of Vitamins from Different Multivitamin Supplements Using a Pig Model

Assessment of In Vitro Bioaccessibility and In Vivo Oral Bioavailability as Complementary Tools to Better Understand the Effect of Cooking on Methylmercury, Arsenic, and Selenium in Tuna

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