Biocatalytic conversion and detoxification of imipramine by the laccase-mediated system

Tahmasbi, Hamed; Khoshayand, Mohammad Reza; Bozorgi-Koushalshahi, Maryam; Heidary, Marjan; Ghazi‐Khansari, Mahmoud; Faramarzi, Mohammad Ali

doi:10.1016/j.ibiod.2015.11.029

Cited by 22 publications

(13 citation statements)

References 41 publications

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“…Afterwards, the absorbance was recorded at 420 nm (ε 420 = 36,000 M −1 cm −1 ) by a Double Beam PC Scanning UV–vis spectrophotometer (UVD 2950, Labomed, Culver City, USA). The amount of enzyme which oxidize 1 μmol of ABTS per minute defined as one unit of laccase activity [ 28 – 31 ].…”

Section: Methodsmentioning

confidence: 99%

Studies on the laccase-mediated decolorization, kinetic, and microtoxicity of some synthetic azo dyes

Forootanfar

Rezaei

Zeinvand-Lorestani

et al. 2016

J Environ Health Sci Engineer

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BackgroundEnzymatic elimination of synthetic dyes, one of the most environmentally hazardous chemicals, has gained a great interest during the two last decades. The present study was performed to evaluate the decolorization and detoxification potential of the purified laccase of Paraconiothyrium variabile in both non-assisted and hydroxybenzotriazole-aided form against six azo dyes.ResultsThe obtained results showed that Acid Orange 67, Disperse Yellow 79, Basic Yellow 28, Basic Red 18, Direct Yellow 107, and Direct Black 166 were decolorized up to 65.3, 53.3, 46.7, 40.7, 34, and 26.2 %, respectively, after 1 h treatment with laccase (0.5 U/mL). Addition of HBT up to 5 mM enhanced decolorization percent of all the investigated dyes. The results of kinetic study introduced the monoazo dye of Acid Orange 67 as the most suitable substrate for laccase with Km of 0.49 mM and Vmax of 189 mmol/min/mg. Evaluation the toxic effect of laccase-treated dye sample based on the growth inhibition of standard bacterial strains revealed decrease in toxicity of all applied dyes after treatment by laccase.ConclusionsApplication of the P. variabile laccase as biocatalyst efficiently decreased the toxicity of all studied synthetic azo dyes.

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Section: Methodsmentioning

confidence: 99%

Studies on the laccase-mediated decolorization, kinetic, and microtoxicity of some synthetic azo dyes

Forootanfar

Rezaei

Zeinvand-Lorestani

et al. 2016

J Environ Health Sci Engineer

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“…Besides antibiotics, many other PPCPs are actively evaluated as laccase substrates, including anticonvulsants (e.g., carbamazepine and benzodiazepines) (Ostadhadi-Dehkordi et al, 2012 ), fungicides (e.g., ketoconazole) (Yousefi-Ahmadipour et al, 2016 ), anti-inflammatory drugs (e.g., acetaminophen, aspirin, diclofenac, and ketoprofen) (Marco-Urrea et al, 2010a ; Ba et al, 2014a ; Domaradzka et al, 2015 ; Singh et al, 2016 ), antidepressants (e.g., imipramine) (Tahmasbi et al, 2016 ), lipid regulators (e.g., clofibric acid) (Ji et al, 2016a ), biocides (triclosan and chlorophene) (Shi et al, 2016 ), insect repellents (e.g., N , N -diethyl-m-toluamide) (Tran et al, 2013 ), and sunscreen agents (e.g., oxybenzone) (Garcia et al, 2011 ).…”

Section: Laccase Applications In Biodegradation Of Ppcpsmentioning

confidence: 99%

Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation

et al. 2017

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Laccases are a family of copper-containing oxidases with important applications in bioremediation and other various industrial and biotechnological areas. There have been over two dozen reviews on laccases since 2010 covering various aspects of this group of versatile enzymes, from their occurrence, biochemical properties, and expression to immobilization and applications. This review is not intended to be all-encompassing; instead, we highlighted some of the latest developments in basic and applied laccase research with an emphasis on laccase-mediated bioremediation of pharmaceuticals, especially antibiotics. Pharmaceuticals are a broad class of emerging organic contaminants that are recalcitrant and prevalent. The recent surge in the relevant literature justifies a short review on the topic. Since low laccase yields in natural and genetically modified hosts constitute a bottleneck to industrial-scale applications, we also accentuated a genus of laccase-producing white-rot fungi, Cerrena, and included a discussion with regards to regulation of laccase expression.

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“…Laccases are low-cost enzymes with high catalytic activity, broad substrate specificity, and beneficial chemical and physical properties [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. To the best of our knowledge, only one example of oxidation of tertiary amines by laccase has been reported; however, the yield and selectivity were low [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity

Zippilli

Botta

Bizzarri

et al. 2021

IJMS

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Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.

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Biocatalytic conversion and detoxification of imipramine by the laccase-mediated system

Cited by 22 publications

References 41 publications

Studies on the laccase-mediated decolorization, kinetic, and microtoxicity of some synthetic azo dyes

Studies on the laccase-mediated decolorization, kinetic, and microtoxicity of some synthetic azo dyes

Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation

Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity

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