Biochemical and Biological Study on The Effect of Flaxseed on Rats Suffer from Nephropathy.

Abstract

The present study was conducted to investigate the effect supplemented diets with different doses of flaxseed on some biological, biochemical and histopathology changes in rats suffering from nephropathy. Thirty adult male albino rats "Sprague were divided into two main groups, the first main group fed on basal diet as a (negative control group). The second main group (24 rats) injection with 10 ml glycerol /kg dissolve in saline solution (glycerol / saline solution v/v) to induce renal failure, the dose of glycerol were injected under slight diethyl ether anesthesia. The second main group divided into four subgroups, the first subgroup fed standard diet (positive control group). The second subgroup fed standard diet containing 3% flaxseed. The third subgroup fed standard diet containing 5% flaxseed. The forth subgroup fed standard diet containing 7% flaxseed. At the end of the experiment (4 weeks), blood samples were taken; serum was separated and subjected to biochemical analysis (renal function). Glutathione, Malondialdehyde and histopathology were exanimated in kidney tissue in all groups. The results indicated that all treated groups get better in body weight gain%, Kidney functions (urea, uric acid and creatinine in serum) and GSH and MDA renal tissue ameliorated especially in renal failure rats fed on diet containing 5% and 7% flaxseed.

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“…Wahba and Ibrahim 45 reported that the administration of flaxseed oil produced significant decreases in the elevated BUN and UA when compared with the positive control group. El-Sayed et al, 46 stated that the renal failure rats fed on a diet containing 5% and 7% flaxseed get better in body weight gain% and kidney functions.…”

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“…[11][12][13][14] As a powerful antioxidant, flaxseed has a role in protecting the liver and kidneys from strong oxidants, 15 and prevent oxidative stress-induced diseases such as renal failure, liver failure, hyperlipidemia, and diabetes. 16 Monosodium glutamate (MSG) was used in Japan as a flavour enhancer in many types of food, producing a flavour called umami meaning savory. 17,18 It is also used in disguised forms, such as in flavoured natural flavours, yeast extract, hydrogenated protein, and in soy protein.…”

Protective Effect of Linum usitatissimum Aqueous Extract against Hepatotoxicity Induced by Monosodium Glutamate in Male Rats

“…[11][12][13][14] As a powerful antioxidant, flaxseed has a role in protecting the liver and kidneys from strong oxidants, 15 and prevent oxidative stress-induced diseases such as renal failure, liver failure, hyperlipidemia, and diabetes. 16 Monosodium glutamate (MSG) was used in Japan as a flavour enhancer in many types of food, producing a flavour called umami meaning savory. 17,18 It is also used in disguised forms, such as in flavoured natural flavours, yeast extract, hydrogenated protein, and in soy protein.…”