Biochemical and Haematological Effects of the Leaf Extract of <i>Newbouldia laevis</i> in Alloxan-Induced Diabetic Rats

Abstract

Dichloromethane-methanol (1:1) extract (DME) of N. laevis leaves was prepared by cold maceration. The effects of the extract on the haematological and some biochemical parameters of alloxan-induced diabetic rats were investigated. The results showed that the oral administration of the extract (250, 500, 1000 mg/kg) caused a significant (P < 0.5) and dose-dependent increase in red blood cell count (RBC) and its indices, as well as a significant (p < 0.05) and dose-dependent reduction in the platelet count and the white blood cells (WBC). The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were significantly (p < 0.05) decreased. This effect was not dose related. The serum levels of total bilirubin, urea and creatinine were significantly (p < 0.05) decreased. The serum total protein and total antioxidant status (TAS) significantly (p < 0.05) increased dose dependently. Overall, administration of DME has significant ameliorative effect on alloxan-induced anaemia and other haematological alterations in diabetes and this may be of immense benefits in the management of diabetes and its associated haematological complications. Improved liver and kidney functions as well as improved antioxidant status are beneficial in the management of chronic diseases such as diabetes.

The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers

“…Renal dysfunction also caused by ROS through hyperglycaemia has been shown to be associated with a decrease in EPO concentration as interstitial fibroblasts responsible for EPO secretion are often destroyed during the development of diabetic nephropathy [20]. However, the administration of OA elevated EPO secretion by the kidneys possibly by overcoming the injury to peritubular interstitial fibroblast cells.…”

Untitled

“…For hepatocytes inflammation and damage, hypoalbuminemia is a strong clinical biomarker. These findings were followed preceding studies (Osigwe et al, 2017;Almalki et al, 2019).…”

Antidiabetic Aptitude of Cordia sebestena and its Outcome on Biochemical Parameters, Serum Electrolytes, and Hematological Markers

“…Hence, assessment of hematological indices is a vital tool in detecting deleterious effect of synthetic drugs and plant extracts. 27 The depletion in RBC count is frequently affiliated to anemia, and its presence in diabetes can be affiliated with various factors such as glomerular filtration rate, urinary albumin excretion rate, and HbA1c levels. 28 Anemia in diabetes is because of increased nonenzymatic glycosylation of RBC membrane protein, which correlates with hyperglycemia and oxidation of glycosylated membrane protein and hyperglycemia resulted in an increase in the development of lipid peroxidases leading to hemolysis.…”