Biochemical blood parameters in semi-adult rabbits experimentally fed crude oil contaminated diets

The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na + /K + /ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1-26

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Histopathological and Biochemical Studies of Some Organs of Male Albino Rat Following Chronic Administration of Benzene

Nasr

Goweder²

2017

Bulletin of Faculty of Science, Zagazig University

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The present study was aimed to investigate the possible biochemical and histopathological effects of benzene on the liver and kidney of male albino rat. Hepatic and renal indices such as alanine and aspartate aminotransferases and alkaline phosphatase, as well as creatinine, urea and uric acid were used as markers of study. Biochemical estimation of hepatic enzymes and renal indices were significantly increased compared to control and confirmed the histopathological results which showed both hepatic and renal damage. It b concluded that the ingestion of benzene-contaminated food showed a deleterious effect the liver and kidney at the employed doses and for the use period.

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Biochemical blood parameters in semi-adult rabbits experimentally fed crude oil contaminated diets

Cited by 14 publications

References 9 publications

Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits

Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Histopathological and Biochemical Studies of Some Organs of Male Albino Rat Following Chronic Administration of Benzene

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