Biochemical changes associated with the fatty liver syndrome in cows

Bogin, E.; Avidar, Y.; Merom, Mira; Soback, S.; Brenner, George M.

doi:10.1016/0021-9975(88)90042-4

Cited by 35 publications

(28 citation statements)

References 18 publications

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“…In our study ASAT activity was significantly increased in all stages of fatty liver compared to normal livers, the increase in ASAT activity did not correlate with the degree of he patic lipid infiltration. This is in agreement with earlier studies (Bogin et al, 1988;Johannsen et al, 1993). Hepatocyte damage may occur due to lipid peroxida tion, oxidative stress and recruited inflammatory cells.…”

Section: Discussionsupporting

confidence: 94%

“…All other liver related parameters, including GLDH, GGT, SDH and Bilirubin were not significantly different between groups, although elevated GLDH activities were observed in cattle with fatty liver in some studies (Bogin et al, 1988;Rehage et al 1996). However, in both stud ies the GLDH activity failed to discriminate between degrees of fatty liver.…”

Section: Discussionmentioning

confidence: 86%

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Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver

Gerspach

Ruetten

Riond

2016

SAT

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The aim of the present study was to investigate clotting profiles, plasma biochemical, and hematological parameters in cows with different degrees of fatty liver. The degree of fatty liver was determined based on histopathology of liver biopsies. Fifty cows referred for left displacement of the abomasum and different degrees of fatty liver were investigated. A clotting profile including prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (aPTT), and fibrinogen did not reveal differences between cows with or without fatty liver. Aspartate aminotransferase (ASAT) was the only biochemical parameter being significantly different in cows with fatty liver. The activity of ASAT could not differentiate any stage of fatty liver. Our findings demonstrate that alterations in clotting profiles in dairy cows are not related to fatty liver. Biochemical parameters are not sufficient to determine the severity of fatty liver. AbstractThe aim of the present study was to investigate clotting profiles, plasma biochemical, and hematological param eters in cows with different degrees of fatty liver. The degree of fatty liver was determined based on histopa thology of liver biopsies. Fifty cows referred for left displacement of the abomasum and different degrees of fatty liver were investigated. A clotting profile including prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (aPTT), and fibrinogen did not reveal differences between cows with or without fatty liver. Aspartate aminotransferase (ASAT) was the only biochemical parameter being significantly different in cows with fatty liver. The activity of ASAT could not differentiate any stage of fatty liver. Our findings demonstrate that alterations in clotting profiles in dairy cows are not related to fatty liver. Biochemical parame ters are not sufficient to determine the severity of fatty liver.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 86%

Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver

Gerspach

Ruetten

Riond

2016

SAT

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“…Previous observations (Bogin et al, 1986;Reid et al, 1983) suggest that there is a significant negative correlation between the degree of fatty changes in the liver and the concentration of serum albumin. There is some evidence that albumin is synthesized exclusively in the rough endoplasmic reticulum of the liver, which is reduced in cows with fatty liver, (Reid and Collins, 1982;Roberts et al, 1981).…”

Section: Resultsmentioning

confidence: 88%

“…Metabolic profiles characteristic of fatty liver cows have been described by many authors (Bogin et al, 1986;Drackley et al, 1992) and correlated with nutrition, fertility and several production diseases.…”

Section: Introductionmentioning

confidence: 99%

Changes in Serum Albumin, Cholesterol and Glucose Concentrations in Subclinical Fatty Liver Syndrome in Dairy Cattle

Mostaghni

Askari

1996

Journal of Applied Animal Research

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“…The significant increase in hepatic G6PD activity in cases of fatty degeneration may be attributable to the deposition of fat in the liver. Hepatic G6PD activity significantly increases in parallel with fatty liver in cattle [5], the increased level of this enzyme generates NADPH, a substrate required for fatty acids synthesis [4]. On the other hand, NADPH is required to regenerate reduced glutathione to maintain protection against hydrogen peroxide [14].…”

Section: Histopathological Findingsmentioning

confidence: 99%

Glutathion Peroxidase and Glucose-6-Phosphate Dehydrogenase Activities in Bovine Blood and Liver

Ellah

Niishimori

Goryo

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. A total of 46 cattle, including 25 as control, 16 with glycogen degeneration and 5 with severe fatty degeneration were studied. Whole blood and liver tissue specimens were used to measure glutathione peroxidase (GSH-Px) and Glucose-6-Phosphate Dehydrogenase (G6PD) activities. The present study determined the value of these parameters in diagnosing glycogen and fatty degeneration in cattle from the point of the status of antioxidation and lipid peroxidation. The results showed a significant decrease in hepatic GSH-Px activity and a significant increase in hepatic G6PD activity in cases of fatty degeneration. On the other hand, there were no significant changes in erythrocytic and hepatic GSH-Px and G6PD activities in cases of glycogen degeneration. The results indicated lipoperoxidation process in the liver tissues increased in cases of fatty degeneration. Therefore, supplying animals suffering from fatty liver with sufficient quantities of nutrient antioxidants may be valuable when treatment is considered.

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Biochemical changes associated with the fatty liver syndrome in cows

Cited by 35 publications

References 18 publications

Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver

Investigation of coagulation and serum biochemistry profiles in dairy cattle with different degrees of fatty liver

Changes in Serum Albumin, Cholesterol and Glucose Concentrations in Subclinical Fatty Liver Syndrome in Dairy Cattle

Glutathion Peroxidase and Glucose-6-Phosphate Dehydrogenase Activities in Bovine Blood and Liver

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