Biochemical Changes in Liver and Blood During Liver Fattening in Rats

Bogin, E.; Avidar, Y.; Merom, Mira

doi:10.1515/cclm.1986.24.9.621

Cited by 16 publications

(14 citation statements)

References 5 publications

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“…The significant increases in serum AST, GGT and ALP, which reflect mainly the status of the liver (Bogin et al, 1986), confirmed the gross and histopathological findings recorded in the present study. The increase in hepatic enzymes was consistent with those observed in male mice (Son et al, 2008).…”

Section: Discussionsupporting

confidence: 91%

Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction

et al. 2010

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Section: Discussionsupporting

confidence: 91%

Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on reproduction

et al. 2010

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“…AST activity significantly increased in bovine serum in cases with liver abscesses [16], liver necrosis [1,21] and severe fatty change [6]. GLDH was significantly elevated in cases with hepatic abscessation [20] and was also increased in fatty liver in cattle [5,20]. Serum γ-GT activity is specific to liver disorders of cattle [17,18] and is a sensitive indicator for cholestasis [7], biliary hyperplasia and hepatocellular damage [10].…”

mentioning

confidence: 99%

Serum Adenosine Deaminase Activity in Bovine Liver Diseases

et al. 2004

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ABSTRACT. A total of 60 cattle were examined for the presence of pathological liver lesions. The liver lesions were classified as glycoge n degeneration, liver abscess, sawdust liver and fatty degeneration. The value of serum adenosine deaminase (ADA) activity was investigated as a pilot study for diagnosing liver diseases in cattle. Serum ADA activity was significantly higher in cases with glycogen degeneration (9.8 ± 3.8 U/l) , liver abscess(10.4 ± 3.2 U/l) , sawdust liver (11.5 ± 7.3U/l) and fatty degeneration (20.8 ± 7.7 U/l) than in the controls. The results indicate that ADA activity increases with the degree of hepatocellular damage. We concluded that serum ADA activity may be of value in bovine liver disease diagnosis. KEY WORDS: adenosine deaminase, bovine, liver disease.J. Vet. Med. Sci. 66(11): 1421-1422, 2004 Adenosine deaminase (ADA) is a purine catabolic enzyme ubiquitous in mammalian tissue with the highest concentration in lymphoid tissues. In vitro it catalyzes deamination of both adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively [3,15]. It was conjectured that its primary function is the detoxification of pharmacologically active adenosine [19]. ADA activity was significantly elevated in sera from human patients with hepatic diseases, hematological malignancies and infectious diseases [12,15]. It is the most useful single test in portal cirrhosis [12]. In bovine studies, it has been reported that elevation of serum ADA activity is accompanied by increase of mononuclear cell infiltration in the liver [9,22] and has been observed in cases of clinical bovine leukemia [23]. We investigated the value of serum adenosine deaminase (ADA) activity as a pilot study for diagnosing liver diseases in cattle, together with the histopathological examination of the affected livers.A total of 60 cattle slaughtered at Asahikawa slaughterhouse (Asahikawa, Hokkaido, Japan), or examined by autopsy at Morioka Livestock Hygiene Center (Morioka, Iwate, Japan), were studied. After collection of blood samples, each animal was examined for presence of pathological lesions. The collected liver samples were kept in (10%) neutral buffered formalin and examined histopathologically [2]. Animals with no abnormal clinical signs and no gross post mortem pathological changes in the liver were used as controls. Types of liver diseases were classified according to the gross and histopathological findings, which were diagnosed as glycogen degeneration, liver abscess, sawdust liver and fatty liver. Histopathological examination of the livers showed the presence of irregular clear spaces in the cytoplasm of the hepatocytes in glycogen degeneration, focal areas of necrosis with neutrophilic infiltration in sawdust liver and rounded fat globules in the hepatocytes that displaced their contents to one side as in severe fatty degeneration.The serum samples were used to measure serum activities of ADA, aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH) and γ-glutamyl transferase (γ-GT). The activiti...

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“…This is in accordance to a study carried out by Dr. D.Amarapurkar et al (10) where it was observed that more cases of NAFLD were reported in patients of the age group of 40-49 who were obese with a sedentary lifestyle. Majority of our study population were obese having mean BMI value 28.9±6.37kg/m 2 ,a characteristic feature and risk factor associated with NAFLD (13) .73(92.4%) patients of the study population were leading sedentary lifestyle which is again an important risk factor associated with NAFLD. This is in accordance with the reportof Shira Zelber-Sagi et al (3) .More than half of the patients in our study were non-vegetarian and spicy eaters and took fast food and soft drinks regularly.…”

Section: Discussionmentioning

confidence: 88%