Biochemical Indices of Macrovascular Complication in Diabetic Rat Model: Compared Effects of Vernonia amygdalina, Catharantus roseus and Chlorpropamide

Eteng, MU; Bassey, B J; Atangwho, Item Justin; Egbung, Godwin Eneji; Eyong, E. U.; Ebong, P. E.; Abolaji, Amos O.

doi:10.3923/ajb.2008.228.234

Cited by 16 publications

(18 citation statements)

References 8 publications

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“…In an acute glucose tolerance test, 400 mg/kg of VA exerted the most effective anti-hyperglycemic activity. This effective dose is similar to that reported in previous studies Eteng et al, 2008). A 28-day chronic study revealed that VA significantly decreased fasting blood glucose.…”

Section: Discussionsupporting

confidence: 88%

“…A 28-day chronic study revealed that VA significantly decreased fasting blood glucose. Both of these designs demonstrated the anti-diabetic efficiency of VA and supported the findings of previous studies (Nwanjo, 2005;Abraham, 2007;Ebong et al, 2008;Eteng et al, 2008). STZ-induced diabetes is characterized by hypoinsulinemia, polydipsia, polyuria and decreased body weight (Kolb, 1987).…”

Section: Discussionsupporting

confidence: 78%

“…Its leaves are consumed either as vegetables (macerated in soup) or aqueous extracts as tonic for the treatment of various diseases (Izevbigie et al, 2008). Since 1992, a number of anti-diabetic studies both in vivo (Akah and Okafor, 1992;Nwanjo, 2005;Abraham, 2007;Ebong et al, 2008;Eteng et al, 2008) and in vitro (Erasto et al, 2009) have indicated VA to possess anti-diabetic property. Besides, a clinical study showed that VA improved fasting blood sugar, glucose tolerance and postprandial blood glucose levels in normoglycemic subjects (Uchenna et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats

Ong

Hsu

Song

et al. 2011

Journal of Ethnopharmacology

116

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats

Ong

Hsu

Song

et al. 2011

Journal of Ethnopharmacology

116

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“…This report for VA extracts is consistent with our earlier reports (Atangwho et al, 2007a;Eteng et al, 2008) and the observed antihyperlipidemic effect of AI extracts had also earlier been reported in STZ treated rats (Chattopadhyay and Bandopadhyay, 2005) and malaria treated human patients (Njoku et al, 2001). However, for the first time combined extracts from these two plants have also shown antihypercholesterolemia and improved atherogenic index in diabetic rats.…”

Section: Discussionsupporting

confidence: 92%

Effect of co-administration of extracts of Vernonia amygdalina and Azadirachta indica on lipid profile and oxidative stress in hepatocytes of normal and diabetic rats

Ebong¹,

Atangwho²

2011

ABJNA

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Effect of combined administration of extracts of Vernonia amydalina (VA) and Azadirachta indica (AI) on oxidative stress indices and serum lipid profile of normal and diabetic rats was evaluated. Result indicated a significant decrease (p<0.05) in catalase (CAT) activity, but non-significant decreases (p>0.05) in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, and in the extent of lipid peroxidation non-significant increase (p>0.05) in malondialdehyde (MDA) concentration of untreated diabetic rats relative to the normal control. Treatment with combined extracts of VA and AI caused significant elevation in GPx, SOD and CAT activities, and reduction in MDA concentration in hepatocytes, hence antioxidant activity. This antioxidant potential was also demonstrated in normal rats which received the treatment. The combined extracts also caused mild increase and decrease in serum high density lipoprotein (HDL) cholesterol and triacylglycerol concentrations, but a respective significant (p<0.05) decrease and increase in serum total cholesterol (TC) and anti-atherogenic index (HDL/TC) when compared to diabetic control. Co-administration of extracts of VA and AI may positively modulate the antioxidant defense system and prevent atherosclerosis in diabetes.

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“…Diabetes mellitus is a complex metabolic disorder in the endocrine system characterized by abnormalities in insulin secretion and/or insulin action that leads to the progressive deterioration of glucose tolerance, which causes hyperglycaemia [1] [2]. There are two main categories of the disease, type 1 diabetes mellitus also called insulin-dependent diabetes mellitus (IDDM) and type 2, the non-insulin dependent diabetes mellitus (NIDDM) [3].…”

Section: Introductionmentioning

confidence: 99%

Lycopene Ameliorates Diabetic-Induced Changes in Erythrocyte Osmotic Fragility and Lipid Peroxidation in Wistar Rats

Eze¹,

Tanko²,

Ahmed³

et al. 2017

JDM

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Introduction: Diabetes mellitus has remained one of the serious health problems in the world; and oxidative stress has been reported to be a root cause for the progression and development of diabetes mellitus and its associated complications. Aim: This study investigated the possible ameliorative effects of lycopene on diabetic-induced changes in erythrocyte osmotic fragility and lipid peroxidation in Wistar rats. Methodology: The animals were made diabetic by single intraperitoneal injection of streptozotocin at 60 mg/kg b w. Diabetes was confirmed by the presence of high fasting blood glucose level ≥ 200 after 72 hours. Thereafter, diabetic rats were randomly assigned into six groups (1, 2, 3, 4, 5 and 6) comprising five animals each. Group 1 (Diabetic control) and group 2 (Normal control) rats received 0.5 ml of olive oil, groups 3, 4, 5 rats received 10, 20, 40 mg/kg bw of lycopene respectively, while those in group 6 received 2 mg/kg bw of glibenclamide orally once daily for a period of four weeks. At the end of the treatment, all animals were sacrificed; blood samples collected for determination of erythrocyte osmotic fragility (EOF) and lipid peroxidation (LPO). Results: The results obtained showed that there was a significantly (P < 0.05) lowered erythrocyte osmotic fragility in diabetic animals treated with lycopene when compared with diabetic control group. In addition, there was also a significantly (P < 0.05) reduced erythrocyte malondialdehyde concentration, an index of lipid peroxidation in the diabetic treated groups when compared with diabetic control group. Conclusion: From the available findings, it can be concluded that administration of lycopene to diabetic rats attenuated diabetic-induced changes in EOF and LPO and these observed effects may be attributed to anti-oxidative property of lycopene.

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Biochemical Indices of Macrovascular Complication in Diabetic Rat Model: Compared Effects of Vernonia amygdalina, Catharantus roseus and Chlorpropamide

Cited by 16 publications

References 8 publications

Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats

Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats

Effect of co-administration of extracts of Vernonia amygdalina and Azadirachta indica on lipid profile and oxidative stress in hepatocytes of normal and diabetic rats

Lycopene Ameliorates Diabetic-Induced Changes in Erythrocyte Osmotic Fragility and Lipid Peroxidation in Wistar Rats

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