Biocompatibility and Biological Performance of the Improved Polyurethane Membranes for Medical Applications

Butnaru, Maria; Bredetean, Ovidiu; Macocinschi, Doina; Dimitriu, Cristina Daniela; Knieling, Laura; Harabagiu, Valeria

doi:10.5772/34653

Cited by 3 publications

(2 citation statements)

References 99 publications

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“…One key drawback of polyurethane is its demonstrated pH cross-sensitivity originating from the protonatable urethane groups, and ionophore-free polyurethane membranes have even been used as pH sensors and as “intelligent polymers” to detect pH changes. , This natural pH response is known to be sufficiently suppressed in membranes containing ionophores such as valinomycin . Importantly, the excellent adhesion, bio- and hemocompatibility, and structural and mechanical adaptability of the polyurethane matrix were subsequently demonstrated. − The improved biocompatibility of the material was evidenced with intra-arterial implantable sensors for potassium detection …”

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Polyurethane Ionophore-Based Thin Layer Membranes for Voltammetric Ion Activity Sensing

2016

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We report on a plasticized polyurethane ionophore-based thin film material (of hundreds of nanometer thickness) for simultaneous voltammetric multianalyte ion activity detection triggered by the oxidation/reduction of an underlying poly(3-octylthiophene) film. This material provides excellent mechanical, physical, and chemical robustness compared to other polymers. Polyurethane films did not exhibit leaching of lipophilic additives after rinsing with a direct water jet and exhibited resistance to detachment from the underlying electrode surface, resulting in a voltammetric current response with less than <1.5% RSD variation (n = 50). In contrast, plasticized poly(vinyl chloride), polystyrene, and poly(acrylate) ionophore-based membranes of the same thickness and composition exhibited a significant deterioration of the signal after identical treatment. While previously reported works emphasized fundamental advancement of multi-ion detection with multi-ionophore-based thin films, polyurethane thin membranes allow one to achieve real world measurements without sacrificing analytical performance. Indeed, polyurethane membranes are demonstrated to be useful for the simultaneous determination of potassium and lithium in undiluted human serum and blood with attractive precision.

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Polyurethane Ionophore-Based Thin Layer Membranes for Voltammetric Ion Activity Sensing

2016

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“…Recently, both academia and industry have invested heavily in the development of new approaches for PU synthesis that considers human health, fossil fuel depletion, and environmental issues (Gerard et al 2012;Poussard et al 2016;Lligadas et al 2010;Kreye et al 2013). In particular, biopolyurethanes for biomedical applications, have been investigated extensively and a great deal of scientific works is focused on improving biocompatibilization or functionalization of usual Pus (Butnaru et al 2012;Burke et al 2017). A promising alternative for this new approach, non-isocyanate polyurethanes (NIPUs), consists in the polyaddition reaction of cyclic carbonates and amines (Cornille et al 2017;Kreye et al 2013;Maisonneuve et al 2015).…”

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confidence: 99%