Polyurethane Ionophore-Based Thin Layer Membranes for Voltammetric Ion Activity Sensing

Cuartero, María; Crespo, Gastón A.; Bakker, Eric

doi:10.1021/acs.analchem.6b01085

Cited by 58 publications

(55 citation statements)

References 35 publications

(84 reference statements)

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“…The spin coating was performed as specified above. PU was in this case preferred to PVC because of increased robustness with thin layer membranes as proven by previous work conducted in our group .…”

Section: Methodsmentioning

confidence: 99%

Thin Layer Membrane Systems as Rapid Development Tool for Potentiometric Solid Contact Ion‐selective Electrodes

2020

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The use of thin membrane layer ion‐selective electrodes (of ∼200 nm thickness) as rapid diagnosis tool is proposed. While conventional solid contact systems (with a membrane of ∼250 μm thickness) may exhibit a satisfactory stability for regular laboratory use, a signal degradation can still be distinguished over a longer period of time but this requires tedious and time consuming tests. By diminishing the thickness of the membrane by a factor of 103 approximately, diffusion processes happen faster, and the lifetime is significantly reduced. This would ordinarily be a strong drawback but not if the aim is to detect a membrane deterioration in a shorter time frame. This characteristic makes thin membrane systems an ideal tool for rapid complications identification in the development process of conventional solid contact electrodes. The approach is demonstrated here in the development of an all new solid contact probe for anions. PEDOT−C14, a conducting polymer, was used for the first time in a solid contact electrode with an anion exchange membrane for the detection of nitrate. The thin layer configuration was used to optimise the polymerisation parameters as well as the membrane composition without having to run week‐long trials. A stable conventional solid contact electrode was in the end successfully developed and exhibited a lower detection limit of 10−5.5 M for nitrate with a stable Nernstian response for several days.

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Section: Methodsmentioning

confidence: 99%

Thin Layer Membrane Systems as Rapid Development Tool for Potentiometric Solid Contact Ion‐selective Electrodes

2020

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“…The lower detection limit observed here satisfies the problem at hand. It is likely caused by the functional groups of polyurethane, which is preferred here over traditional poly(vinyl chloride) because of its superior adhesive properties and resulting sensor lifetime …”

Section: Methodsmentioning

confidence: 99%

Light‐Addressable Ion Sensing for Real‐Time Monitoring of Extracellular Potassium

et al. 2018

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We report here on a light addressable potassium (K+) sensor where light illumination of a semiconducting silicon electrode substrate results in a localized activation of the faradaic electrochemistry at the illuminated spot. This allows one, by electrochemical control, to oxidize surface bound ferrocene moieties that in turn trigger K+ transfer from the overlaid K+‐selective film to the solution phase. The resulting voltammetric response is shown to be K+‐selective, where peak position is a direct function of K+ activity at the surface of electrode. This concept was used to measure extracellular K+ concentration changes by stimulating living breast cancer cells. The associated decrease of intracellular K+ level was confirmed with a fluorescent K+ indicator. In contrast to light addressable potentiometry, the approach introduced here relies on dynamic electrochemistry and may be performed in tandem with other electrochemical analysis when studying biological events on the electrode.

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“…Ion transfer at the membrane surface occurs at specific potentials for different ions depending on the ionophore used (59-62). Although not all materials utilizing the thin membrane sensors are suitably robust for some biological samples, a recent polyurethane ionophore was able to detect lithium and potassium ions in a single scan in undiluted plasma and serum (61). ISEs enhanced with ion-exchange exclusion membranes have improved the separation efficiencies and sensor lifetimes, enabling them to be used in complex clinical samples (63)(64)(65)(66).…”

Section: Multiplexed Electrolyte Detectionmentioning

confidence: 99%

Multianalyte Physiological Microanalytical Devices

Davis

Travis

Miller

et al. 2017

Annual Rev. Anal. Chem.

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Advances in scientific instrumentation have allowed experimentalists to evaluate well-known systems in new ways and to gain insight into previously unexplored or poorly understood phenomena. Within the growing field of multianalyte physiometry (MAP), microphysiometers are being developed that are capable of electrochemically measuring changes in the concentration of various metabolites in real time. By simultaneously quantifying multiple analytes, these devices have begun to unravel the complex pathways that govern biological responses to ischemia and oxidative stress while contributing to basic scientific discoveries in bioenergetics and neurology. Patients and clinicians have also benefited from the highly translational nature of MAP, and the continued expansion of the repertoire of analytes that can be measured with multianalyte microphysiometers will undoubtedly play a role in the automation and personalization of medicine. This is perhaps most evident with the recent advent of fully integrated noninvasive sensor arrays that can continuously monitor changes in analytes linked to specific disease states and deliver a therapeutic agent as required without the need for patient action.

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Polyurethane Ionophore-Based Thin Layer Membranes for Voltammetric Ion Activity Sensing

Cited by 58 publications

References 35 publications

Thin Layer Membrane Systems as Rapid Development Tool for Potentiometric Solid Contact Ion‐selective Electrodes

Thin Layer Membrane Systems as Rapid Development Tool for Potentiometric Solid Contact Ion‐selective Electrodes

Light‐Addressable Ion Sensing for Real‐Time Monitoring of Extracellular Potassium

Multianalyte Physiological Microanalytical Devices

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