Biocompatibility and bone formation with porous modified PMMA in normal and irradiated mandibular tissue

Lye, Kok Weng; Tideman, H.; Wolke, Joop C.G.; Merkx, Matthias A.W.; Chin, Francis; Jansen, John A.

doi:10.1111/j.1600-0501.2011.02388.x

Cited by 30 publications

(27 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…New nanostructured polymer membranes based on polymethylmethacrylate are proposed. Polymethylmethacrylates (PMMA) are non-reabsorbable but biocompatible polymers, which have been widely used to clinically fix prostheses to bone or for vertebroplasty, intraocular lenses, orthopaedic bone cements, skull defects reparation or mandibular reconstruction between others, due to its excellent tissue compatibility [6,7]. Presented polymeric solution may be spun.…”

Section: Introductionmentioning

confidence: 99%

Novel potential scaffold for periodontal tissue engineering

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Novel potential scaffold for periodontal tissue engineering

et al. 2017

View full text Add to dashboard Cite

show abstract

“…For many of these applications, such as mandibular reconstruction or intraocular lenses, a good cell–biomaterial interaction is paramount for the integration of the implant, and the stability of the fixation on the interface or the prevention of cataract, respectively. However, PMMA shows weak or null interactivity against tissue cells, which promotes the formation of fibrotic tissue [ 10 , 11 ]. The formation of fibrotic tissue around the implant is known to be one of the most common causes of implant integration failure, which compromises its long-term viability [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Biomolecular functionalization for enhanced cell–material interactions of poly(methyl methacrylate) surfaces

et al. 2015

View full text Add to dashboard Cite

The integration of implants or medical devices into the body tissues requires of good cell–material interactions. However, most polymeric materials used for these applications lack on biological cues, which enhanced mid- and long-term implant failure due to weak integration with the surrounding tissue. Commonly used strategies for tissue–material integration focus on functionalization of the material surface by means of natural proteins or short peptides. However, the use of these biomolecules involves major drawbacks such as immunogenic problems and oversimplification of the constructs. Here, designed elastin-like recombinamers (ELRs) are used to enhance poly(methyl methacrylate) surface properties and compared against the use of short peptides. In this study, cell response has been analysed for different functionalization conditions in the presence and absence of a competing protein, which interferes on surface–cell interaction by unspecific adsorption on the interface. The study has shown that ELRs can induce higher rates of cell attachment and stronger cell anchorages than short peptides, being a better choice for surface functionalization.

show abstract

“…Formation of an apatite or hydroxyapatite layer on the surface in SBF is considered an indication of bone adhesion potential. However, making the PMMA surface porous is an alternative route to provide good bone tissue adhesion . We have tested the samples for surface changes by soaking them in SBF for 20 days.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and study of new functionalized silica aerogel poly(methyl methacrylate) composites for biomedical use

et al. 2014

View full text Add to dashboard Cite

Monolithic silica aerogels are nanostructured solids characterized with exceptionally high porosity and specific surface area. Although their strength can be improved by surface treatment with polymers, none of them has been tested yet as a filler in biocompatible polymer composites. The new aerogel-poly(methyl methacrylate) composites were prepared by free radical bulk polymerization of neat methyl methacrylate in the presence of natural and functionalized silica aerogels at 60 °C, using cumene hydroperoxide initiator and 4,N,N-trimethylaniline redox pair. Synthetic conditions were set to be most similar to the setting of orthopedic bone cements.Structures, compositions, and molecular weight distributions were determined by scanning electron microscopy, combustion analysis and gel permeation chromatography, respectively. Compressive strength, Shore D hardness and Gardner's impact strength were measured, and the fracture properties were compared to the matrices. All four aerogel fillers resulted in significant enhancement in compressive strength, reaching a maximum value of 123 MPa. Dissolution of H103PC-1 natural and H106PB-1 C16 modified aerogel containing specimens in simulated body fluid occurred in twenty days, leaving porous surfaces behind, which may give rise to higher tissue adhesion potential in bone cements. Heat treated silica aerogel in H112PA-1 showed no leaching out, and its composites might be usefull in high-load technical applications.3

show abstract

Biocompatibility and bone formation with porous modified PMMA in normal and irradiated mandibular tissue

Abstract: Both modified PMMA cements have good biocompatibility, bioactivity and support bone ingrowth and additional post-operative radiation did not show any negative effects.

Cited by 30 publications

References 40 publications

Novel potential scaffold for periodontal tissue engineering

Novel potential scaffold for periodontal tissue engineering

Biomolecular functionalization for enhanced cell–material interactions of poly(methyl methacrylate) surfaces

Synthesis and study of new functionalized silica aerogel poly(methyl methacrylate) composites for biomedical use

Contact Info

Product

Resources

About